Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution
Abstract Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approa...
Published in: | Genome Biology and Evolution |
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Oxford University Press (OUP)
2023
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Online Access: | http://dx.doi.org/10.1093/gbe/evad159 https://academic.oup.com/gbe/advance-article-pdf/doi/10.1093/gbe/evad159/51309285/evad159.pdf https://academic.oup.com/gbe/article-pdf/15/11/evad159/53404247/evad159.pdf |
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croxfordunivpr:10.1093/gbe/evad159 2024-05-19T07:36:55+00:00 Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution Iannello, Mariangela Forni, Giobbe Piccinini, Giovanni Xu, Ran Martelossi, Jacopo Ghiselli, Fabrizio Milani, Liliana Alba, Mar 2023 http://dx.doi.org/10.1093/gbe/evad159 https://academic.oup.com/gbe/advance-article-pdf/doi/10.1093/gbe/evad159/51309285/evad159.pdf https://academic.oup.com/gbe/article-pdf/15/11/evad159/53404247/evad159.pdf en eng Oxford University Press (OUP) https://creativecommons.org/licenses/by-nc/4.0/ Genome Biology and Evolution volume 15, issue 11 ISSN 1759-6653 journal-article 2023 croxfordunivpr https://doi.org/10.1093/gbe/evad159 2024-05-02T09:29:44Z Abstract Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approach in this instance. Here, we leveraged transcriptomic resources spanning 30 bivalve species to unravel the signatures of convergent molecular evolution in four long-lived species: Margaritifera margaritifera, Elliptio complanata, Lampsilis siliquoidea, and Arctica islandica (the latter represents the longest-lived noncolonial metazoan known so far). We applied a comprehensive approach—which included inference of convergent dN/dS, convergent positive selection, and convergent amino acid substitution—with a strong focus on the reduction of false positives. Genes with convergent evolution in long-lived bivalves show more physical and functional interactions to each other than expected, suggesting that they are biologically connected; this interaction network is enriched in genes for which a role in longevity has been experimentally supported in other species. This suggests that genes in the network are involved in extended longevity in bivalves and, consequently, that the mechanisms underlying extended longevity are—at least partially—shared across Metazoa. Although we believe that an integration of different genes and pathways is required for the extended longevity phenotype, we highlight the potential central roles of genes involved in cell proliferation control, translational machinery, and response to hypoxia, in lifespan extension. Article in Journal/Newspaper Arctica islandica Oxford University Press Genome Biology and Evolution |
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English |
description |
Abstract Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approach in this instance. Here, we leveraged transcriptomic resources spanning 30 bivalve species to unravel the signatures of convergent molecular evolution in four long-lived species: Margaritifera margaritifera, Elliptio complanata, Lampsilis siliquoidea, and Arctica islandica (the latter represents the longest-lived noncolonial metazoan known so far). We applied a comprehensive approach—which included inference of convergent dN/dS, convergent positive selection, and convergent amino acid substitution—with a strong focus on the reduction of false positives. Genes with convergent evolution in long-lived bivalves show more physical and functional interactions to each other than expected, suggesting that they are biologically connected; this interaction network is enriched in genes for which a role in longevity has been experimentally supported in other species. This suggests that genes in the network are involved in extended longevity in bivalves and, consequently, that the mechanisms underlying extended longevity are—at least partially—shared across Metazoa. Although we believe that an integration of different genes and pathways is required for the extended longevity phenotype, we highlight the potential central roles of genes involved in cell proliferation control, translational machinery, and response to hypoxia, in lifespan extension. |
author2 |
Alba, Mar |
format |
Article in Journal/Newspaper |
author |
Iannello, Mariangela Forni, Giobbe Piccinini, Giovanni Xu, Ran Martelossi, Jacopo Ghiselli, Fabrizio Milani, Liliana |
spellingShingle |
Iannello, Mariangela Forni, Giobbe Piccinini, Giovanni Xu, Ran Martelossi, Jacopo Ghiselli, Fabrizio Milani, Liliana Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
author_facet |
Iannello, Mariangela Forni, Giobbe Piccinini, Giovanni Xu, Ran Martelossi, Jacopo Ghiselli, Fabrizio Milani, Liliana |
author_sort |
Iannello, Mariangela |
title |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_short |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_full |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_fullStr |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_full_unstemmed |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_sort |
signatures of extreme longevity: a perspective from bivalve molecular evolution |
publisher |
Oxford University Press (OUP) |
publishDate |
2023 |
url |
http://dx.doi.org/10.1093/gbe/evad159 https://academic.oup.com/gbe/advance-article-pdf/doi/10.1093/gbe/evad159/51309285/evad159.pdf https://academic.oup.com/gbe/article-pdf/15/11/evad159/53404247/evad159.pdf |
genre |
Arctica islandica |
genre_facet |
Arctica islandica |
op_source |
Genome Biology and Evolution volume 15, issue 11 ISSN 1759-6653 |
op_rights |
https://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1093/gbe/evad159 |
container_title |
Genome Biology and Evolution |
_version_ |
1799476068409671680 |