Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals
Abstract High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this...
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Oxford University Press (OUP)
2021
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Online Access: | http://dx.doi.org/10.1093/g3journal/jkab069 http://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkab069/37005231/jkab069.pdf http://academic.oup.com/g3journal/article-pdf/11/4/jkab069/37082993/jkab069.pdf |
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croxfordunivpr:10.1093/g3journal/jkab069 2024-09-15T18:39:11+00:00 Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping Pardo-Manuel de Villena, F National Natural Science Foundation of China 2021 http://dx.doi.org/10.1093/g3journal/jkab069 http://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkab069/37005231/jkab069.pdf http://academic.oup.com/g3journal/article-pdf/11/4/jkab069/37082993/jkab069.pdf en eng Oxford University Press (OUP) http://creativecommons.org/licenses/by/4.0/ G3 Genes|Genomes|Genetics volume 11, issue 4 ISSN 2160-1836 journal-article 2021 croxfordunivpr https://doi.org/10.1093/g3journal/jkab069 2024-08-12T04:23:49Z Abstract High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this study, we present two additional candidate hearing-related genes, Shh and SK2, that may also have contributed to the evolution of echolocation in mammals. Shh is a member of the vertebrate Hedgehog gene family and is required in the specification of the mammalian cochlea. SK2 is expressed in both inner and outer hair cells, and it plays an important role in the auditory system. The coding region sequences of Shh and SK2 were obtained from a wide range of mammals with and without echolocating ability. The topologies of phylogenetic trees constructed using Shh and SK2 were different; however, multiple molecular evolutionary analyses showed that those two genes experienced different selective pressures in echolocating bats and toothed whales compared to nonecholocating mammals. In addition, several nominally significant positively selected sites were detected in the nonfunctional domain of the SK2 gene, indicating that different selective pressures were acting on different parts of the SK2 gene. This study has expanded our knowledge of the adaptive evolution of high-frequency hearing in echolocating mammals. Article in Journal/Newspaper toothed whales Oxford University Press G3 Genes|Genomes|Genetics 11 4 |
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Oxford University Press |
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croxfordunivpr |
language |
English |
description |
Abstract High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this study, we present two additional candidate hearing-related genes, Shh and SK2, that may also have contributed to the evolution of echolocation in mammals. Shh is a member of the vertebrate Hedgehog gene family and is required in the specification of the mammalian cochlea. SK2 is expressed in both inner and outer hair cells, and it plays an important role in the auditory system. The coding region sequences of Shh and SK2 were obtained from a wide range of mammals with and without echolocating ability. The topologies of phylogenetic trees constructed using Shh and SK2 were different; however, multiple molecular evolutionary analyses showed that those two genes experienced different selective pressures in echolocating bats and toothed whales compared to nonecholocating mammals. In addition, several nominally significant positively selected sites were detected in the nonfunctional domain of the SK2 gene, indicating that different selective pressures were acting on different parts of the SK2 gene. This study has expanded our knowledge of the adaptive evolution of high-frequency hearing in echolocating mammals. |
author2 |
Pardo-Manuel de Villena, F National Natural Science Foundation of China |
format |
Article in Journal/Newspaper |
author |
Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping |
spellingShingle |
Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
author_facet |
Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping |
author_sort |
Wang, Hui |
title |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_short |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_full |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_fullStr |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_full_unstemmed |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_sort |
assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
publisher |
Oxford University Press (OUP) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1093/g3journal/jkab069 http://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkab069/37005231/jkab069.pdf http://academic.oup.com/g3journal/article-pdf/11/4/jkab069/37082993/jkab069.pdf |
genre |
toothed whales |
genre_facet |
toothed whales |
op_source |
G3 Genes|Genomes|Genetics volume 11, issue 4 ISSN 2160-1836 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1093/g3journal/jkab069 |
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G3 Genes|Genomes|Genetics |
container_volume |
11 |
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4 |
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1810483589748359168 |