Independent evolution toward larger body size in the distinctive Faroe Island mice
Abstract Most phenotypic traits in nature involve the collective action of many genes. Traits that evolve repeatedly are particularly useful for understanding how selection may act on changing trait values. In mice, large body size has evolved repeatedly on islands and under artificial selection in...
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2021
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croxfordunivpr:10.1093/g3journal/jkaa051 2024-04-07T07:52:21+00:00 Independent evolution toward larger body size in the distinctive Faroe Island mice Wilches, Ricardo Beluch, William H McConnell, Ellen Tautz, Diethard Chan, Yingguang Frank Rockman, M Max Planck Society Max Planck Society 2021 http://dx.doi.org/10.1093/g3journal/jkaa051 http://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkaa051/35387301/jkaa051.pdf http://academic.oup.com/g3journal/article-pdf/11/1/jkaa051/38018080/jkaa051.pdf en eng Oxford University Press (OUP) http://creativecommons.org/licenses/by/4.0/ G3 Genes|Genomes|Genetics volume 11, issue 1 ISSN 2160-1836 Genetics (clinical) Genetics Molecular Biology journal-article 2021 croxfordunivpr https://doi.org/10.1093/g3journal/jkaa051 2024-03-08T03:00:10Z Abstract Most phenotypic traits in nature involve the collective action of many genes. Traits that evolve repeatedly are particularly useful for understanding how selection may act on changing trait values. In mice, large body size has evolved repeatedly on islands and under artificial selection in the laboratory. Identifying the loci and genes involved in this process may shed light on the evolution of complex, polygenic traits. Here, we have mapped the genetic basis of body size variation by making a genetic cross between mice from the Faroe Islands, which are among the largest and most distinctive natural populations of mice in the world, and a laboratory mouse strain selected for small body size, SM/J. Using this F2 intercross of 841 animals, we have identified 111 loci controlling various aspects of body size, weight and growth hormone levels. By comparing against other studies, including the use of a joint meta-analysis, we found that the loci involved in the evolution of large size in the Faroese mice were largely independent from those of a different island population or other laboratory strains. We hypothesize that colonization bottleneck, historical hybridization, or the redundancy between multiple loci have resulted in the Faroese mice achieving an outwardly similar phenotype through a distinct evolutionary path. Article in Journal/Newspaper Faroe Islands Oxford University Press Faroe Islands G3 Genes|Genomes|Genetics 11 1 |
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Open Polar |
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Oxford University Press |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Genetics (clinical) Genetics Molecular Biology |
spellingShingle |
Genetics (clinical) Genetics Molecular Biology Wilches, Ricardo Beluch, William H McConnell, Ellen Tautz, Diethard Chan, Yingguang Frank Independent evolution toward larger body size in the distinctive Faroe Island mice |
topic_facet |
Genetics (clinical) Genetics Molecular Biology |
description |
Abstract Most phenotypic traits in nature involve the collective action of many genes. Traits that evolve repeatedly are particularly useful for understanding how selection may act on changing trait values. In mice, large body size has evolved repeatedly on islands and under artificial selection in the laboratory. Identifying the loci and genes involved in this process may shed light on the evolution of complex, polygenic traits. Here, we have mapped the genetic basis of body size variation by making a genetic cross between mice from the Faroe Islands, which are among the largest and most distinctive natural populations of mice in the world, and a laboratory mouse strain selected for small body size, SM/J. Using this F2 intercross of 841 animals, we have identified 111 loci controlling various aspects of body size, weight and growth hormone levels. By comparing against other studies, including the use of a joint meta-analysis, we found that the loci involved in the evolution of large size in the Faroese mice were largely independent from those of a different island population or other laboratory strains. We hypothesize that colonization bottleneck, historical hybridization, or the redundancy between multiple loci have resulted in the Faroese mice achieving an outwardly similar phenotype through a distinct evolutionary path. |
author2 |
Rockman, M Max Planck Society Max Planck Society |
format |
Article in Journal/Newspaper |
author |
Wilches, Ricardo Beluch, William H McConnell, Ellen Tautz, Diethard Chan, Yingguang Frank |
author_facet |
Wilches, Ricardo Beluch, William H McConnell, Ellen Tautz, Diethard Chan, Yingguang Frank |
author_sort |
Wilches, Ricardo |
title |
Independent evolution toward larger body size in the distinctive Faroe Island mice |
title_short |
Independent evolution toward larger body size in the distinctive Faroe Island mice |
title_full |
Independent evolution toward larger body size in the distinctive Faroe Island mice |
title_fullStr |
Independent evolution toward larger body size in the distinctive Faroe Island mice |
title_full_unstemmed |
Independent evolution toward larger body size in the distinctive Faroe Island mice |
title_sort |
independent evolution toward larger body size in the distinctive faroe island mice |
publisher |
Oxford University Press (OUP) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1093/g3journal/jkaa051 http://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkaa051/35387301/jkaa051.pdf http://academic.oup.com/g3journal/article-pdf/11/1/jkaa051/38018080/jkaa051.pdf |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
G3 Genes|Genomes|Genetics volume 11, issue 1 ISSN 2160-1836 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1093/g3journal/jkaa051 |
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G3 Genes|Genomes|Genetics |
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11 |
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1 |
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1795667636805173248 |