Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS
ABSTRACT Staphylococcus epidermidis is well known to be one of the major causes of infections related to medical devices, mostly due to its strong capacity to form device-associated biofilms. Nowadays, these infections represent a severe burden to the public health system and the necessity of novel...
Published in: | Pathogens and Disease |
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Oxford University Press (OUP)
2020
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croxfordunivpr:10.1093/femspd/ftaa012 2023-12-31T10:01:02+01:00 Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS Ricciardelli, Annarita Casillo, Angela Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda van der Mei, Henny C 2020 http://dx.doi.org/10.1093/femspd/ftaa012 http://academic.oup.com/femspd/advance-article-pdf/doi/10.1093/femspd/ftaa012/32677536/ftaa012.pdf http://academic.oup.com/femspd/article-pdf/78/3/ftaa012/38097678/ftaa012.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Pathogens and Disease volume 78, issue 3 ISSN 2049-632X Infectious Diseases Microbiology (medical) General Immunology and Microbiology General Medicine Immunology and Allergy journal-article 2020 croxfordunivpr https://doi.org/10.1093/femspd/ftaa012 2023-12-06T08:51:37Z ABSTRACT Staphylococcus epidermidis is well known to be one of the major causes of infections related to medical devices, mostly due to its strong capacity to form device-associated biofilms. Nowadays, these infections represent a severe burden to the public health system and the necessity of novel antibacterial strategies for the treatment of these difficult-to-eradicate infections is urgent. The Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125 was found to be able to produce an anti-biofilm molecule, the pentadecanal, active against S. epidermidis. In this work, we modified one of the most widely used silicone-based polymers, polydimethylsiloxane (PDMS), by adsorption of pentadecanal and its most promising derivative, pentadecanoic acid, on the PDMS surface. The biofilm formation of S. epidermidis RP62A on both untreated and modified PDMS was performed in a parallel plate flow chamber system, demonstrating the capability of the proposed anti-biofilm coatings to strongly reduce the biofilm formation. Furthermore, drug-release capacity and long-term efficacy (21 days) were also proven for the pentadecanoic acid coating. Article in Journal/Newspaper Antarc* Antarctic Oxford University Press (via Crossref) Pathogens and Disease 78 3 |
institution |
Open Polar |
collection |
Oxford University Press (via Crossref) |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Infectious Diseases Microbiology (medical) General Immunology and Microbiology General Medicine Immunology and Allergy |
spellingShingle |
Infectious Diseases Microbiology (medical) General Immunology and Microbiology General Medicine Immunology and Allergy Ricciardelli, Annarita Casillo, Angela Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda van der Mei, Henny C Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS |
topic_facet |
Infectious Diseases Microbiology (medical) General Immunology and Microbiology General Medicine Immunology and Allergy |
description |
ABSTRACT Staphylococcus epidermidis is well known to be one of the major causes of infections related to medical devices, mostly due to its strong capacity to form device-associated biofilms. Nowadays, these infections represent a severe burden to the public health system and the necessity of novel antibacterial strategies for the treatment of these difficult-to-eradicate infections is urgent. The Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125 was found to be able to produce an anti-biofilm molecule, the pentadecanal, active against S. epidermidis. In this work, we modified one of the most widely used silicone-based polymers, polydimethylsiloxane (PDMS), by adsorption of pentadecanal and its most promising derivative, pentadecanoic acid, on the PDMS surface. The biofilm formation of S. epidermidis RP62A on both untreated and modified PDMS was performed in a parallel plate flow chamber system, demonstrating the capability of the proposed anti-biofilm coatings to strongly reduce the biofilm formation. Furthermore, drug-release capacity and long-term efficacy (21 days) were also proven for the pentadecanoic acid coating. |
format |
Article in Journal/Newspaper |
author |
Ricciardelli, Annarita Casillo, Angela Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda van der Mei, Henny C |
author_facet |
Ricciardelli, Annarita Casillo, Angela Corsaro, Maria Michela Tutino, Maria Luisa Parrilli, Ermenegilda van der Mei, Henny C |
author_sort |
Ricciardelli, Annarita |
title |
Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS |
title_short |
Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS |
title_full |
Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS |
title_fullStr |
Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS |
title_full_unstemmed |
Pentadecanal and pentadecanoic acid coatings reduce biofilm formation of Staphylococcus epidermidis on PDMS |
title_sort |
pentadecanal and pentadecanoic acid coatings reduce biofilm formation of staphylococcus epidermidis on pdms |
publisher |
Oxford University Press (OUP) |
publishDate |
2020 |
url |
http://dx.doi.org/10.1093/femspd/ftaa012 http://academic.oup.com/femspd/advance-article-pdf/doi/10.1093/femspd/ftaa012/32677536/ftaa012.pdf http://academic.oup.com/femspd/article-pdf/78/3/ftaa012/38097678/ftaa012.pdf |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Pathogens and Disease volume 78, issue 3 ISSN 2049-632X |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/femspd/ftaa012 |
container_title |
Pathogens and Disease |
container_volume |
78 |
container_issue |
3 |
_version_ |
1786794307970138112 |