Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder
Abstract Background To study the associations between maternal smoking during pregnancy and paternal smoking before pregnancy and adult offspring psychiatric disorders. Methods Prospective general population cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986: 7...
Published in: | European Journal of Public Health |
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Oxford University Press (OUP)
2022
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Online Access: | http://dx.doi.org/10.1093/eurpub/ckac004 https://academic.oup.com/eurpub/advance-article-pdf/doi/10.1093/eurpub/ckac004/42331438/ckac004.pdf https://academic.oup.com/eurpub/article-pdf/32/2/254/43658175/ckac004.pdf |
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croxfordunivpr:10.1093/eurpub/ckac004 2023-05-15T17:42:23+02:00 Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder Sarala, Marian Mustonen, Antti Alakokkare, Anni-Emilia Salom, Caroline Miettunen, Jouko Niemelä, Solja European Union EUROBLCS National Institute of Health 2000 Juho Vainio foundation Sohlberg foundation 2022 http://dx.doi.org/10.1093/eurpub/ckac004 https://academic.oup.com/eurpub/advance-article-pdf/doi/10.1093/eurpub/ckac004/42331438/ckac004.pdf https://academic.oup.com/eurpub/article-pdf/32/2/254/43658175/ckac004.pdf en eng Oxford University Press (OUP) https://creativecommons.org/licenses/by/4.0/ CC-BY European Journal of Public Health volume 32, issue 2, page 254-260 ISSN 1101-1262 1464-360X Public Health, Environmental and Occupational Health journal-article 2022 croxfordunivpr https://doi.org/10.1093/eurpub/ckac004 2022-05-17T05:38:56Z Abstract Background To study the associations between maternal smoking during pregnancy and paternal smoking before pregnancy and adult offspring psychiatric disorders. Methods Prospective general population cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986: 7259 subjects (77% of the original sample). Data on parental smoking were collected from parents during pregnancy using questionnaires. Outcomes were offspring’s register-based diagnoses: any psychiatric disorder, any non-organic psychosis, mood disorder, anxiety disorder and substance use disorder (SUD) until the age of 29–30 years. Maternal smoking during pregnancy and paternal smoking before pregnancy were pooled to three-class variables: (i) none; (ii) 1–9 and (iii) ≥10 cigarettes/day. Information regarding both parents’ alcohol use during pregnancy and at offspring age 15–16 years, maternal education level, family structure, parental psychiatric diagnoses and offspring gender, smoking, intoxication frequency and illicit substance use at the age of 15–16 years were investigated as covariates. Results In the multivariable analyses, maternal smoking during pregnancy did not associate with the studied outcomes after adjusting for offspring smoking and other substance use at offspring age 15–16 years and parental psychiatric disorders. However, paternal smoking ≥10 cigarettes/day before pregnancy [hazard ratio (HR) = 5.5, 95% confidence interval (CI) 2.7–11.2, P < 0.001] and paternal psychiatric disorders (HR = 1.7, 95% CI 1.1–2.8, P = 0.028) associated with offspring SUD after adjustments. Conclusions Information across the offspring life course is essential in exploring the association between parental smoking and offspring psychiatric disorders. Paternal smoking before pregnancy and paternal psychiatric disorders may act as modifiers in elevating the risk of substance-use-related problems among offspring. Article in Journal/Newspaper Northern Finland Oxford University Press (via Crossref) European Journal of Public Health 32 2 254 260 |
institution |
Open Polar |
collection |
Oxford University Press (via Crossref) |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Public Health, Environmental and Occupational Health |
spellingShingle |
Public Health, Environmental and Occupational Health Sarala, Marian Mustonen, Antti Alakokkare, Anni-Emilia Salom, Caroline Miettunen, Jouko Niemelä, Solja Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
topic_facet |
Public Health, Environmental and Occupational Health |
description |
Abstract Background To study the associations between maternal smoking during pregnancy and paternal smoking before pregnancy and adult offspring psychiatric disorders. Methods Prospective general population cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986: 7259 subjects (77% of the original sample). Data on parental smoking were collected from parents during pregnancy using questionnaires. Outcomes were offspring’s register-based diagnoses: any psychiatric disorder, any non-organic psychosis, mood disorder, anxiety disorder and substance use disorder (SUD) until the age of 29–30 years. Maternal smoking during pregnancy and paternal smoking before pregnancy were pooled to three-class variables: (i) none; (ii) 1–9 and (iii) ≥10 cigarettes/day. Information regarding both parents’ alcohol use during pregnancy and at offspring age 15–16 years, maternal education level, family structure, parental psychiatric diagnoses and offspring gender, smoking, intoxication frequency and illicit substance use at the age of 15–16 years were investigated as covariates. Results In the multivariable analyses, maternal smoking during pregnancy did not associate with the studied outcomes after adjusting for offspring smoking and other substance use at offspring age 15–16 years and parental psychiatric disorders. However, paternal smoking ≥10 cigarettes/day before pregnancy [hazard ratio (HR) = 5.5, 95% confidence interval (CI) 2.7–11.2, P < 0.001] and paternal psychiatric disorders (HR = 1.7, 95% CI 1.1–2.8, P = 0.028) associated with offspring SUD after adjustments. Conclusions Information across the offspring life course is essential in exploring the association between parental smoking and offspring psychiatric disorders. Paternal smoking before pregnancy and paternal psychiatric disorders may act as modifiers in elevating the risk of substance-use-related problems among offspring. |
author2 |
European Union EUROBLCS National Institute of Health 2000 Juho Vainio foundation Sohlberg foundation |
format |
Article in Journal/Newspaper |
author |
Sarala, Marian Mustonen, Antti Alakokkare, Anni-Emilia Salom, Caroline Miettunen, Jouko Niemelä, Solja |
author_facet |
Sarala, Marian Mustonen, Antti Alakokkare, Anni-Emilia Salom, Caroline Miettunen, Jouko Niemelä, Solja |
author_sort |
Sarala, Marian |
title |
Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
title_short |
Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
title_full |
Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
title_fullStr |
Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
title_full_unstemmed |
Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
title_sort |
parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder |
publisher |
Oxford University Press (OUP) |
publishDate |
2022 |
url |
http://dx.doi.org/10.1093/eurpub/ckac004 https://academic.oup.com/eurpub/advance-article-pdf/doi/10.1093/eurpub/ckac004/42331438/ckac004.pdf https://academic.oup.com/eurpub/article-pdf/32/2/254/43658175/ckac004.pdf |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
European Journal of Public Health volume 32, issue 2, page 254-260 ISSN 1101-1262 1464-360X |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/eurpub/ckac004 |
container_title |
European Journal of Public Health |
container_volume |
32 |
container_issue |
2 |
container_start_page |
254 |
op_container_end_page |
260 |
_version_ |
1766144239541944320 |