P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population
Abstract Aims Heart failure (HF) is an increasingly important contributor to the overall burden of cardiovascular disease in the population. We aimed to determine the distribution of the cardiac biomarkers high-sensitivity cardiac troponin I (hs-cTnI) and N-terminal prohormone of brain natriuretic p...
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2019
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Online Access: | http://dx.doi.org/10.1093/eurheartj/ehz748.0401 http://academic.oup.com/eurheartj/article-pdf/40/Supplement_1/ehz748.0401/30201771/ehz748.0401.pdf |
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croxfordunivpr:10.1093/eurheartj/ehz748.0401 2023-05-15T17:45:12+02:00 P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population Yan, I Boerschel, C Neumann, J Spruenker, N Kontto, J Kuulasmaa, K Salomaa, V Iacoviello, L Di Castelnuovo, A Costanzo, S Linneberg, A Soederberg, S Zeller, T Blankenberg, S Westermann, D 2019 http://dx.doi.org/10.1093/eurheartj/ehz748.0401 http://academic.oup.com/eurheartj/article-pdf/40/Supplement_1/ehz748.0401/30201771/ehz748.0401.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model European Heart Journal volume 40, issue Supplement_1 ISSN 0195-668X 1522-9645 Cardiology and Cardiovascular Medicine journal-article 2019 croxfordunivpr https://doi.org/10.1093/eurheartj/ehz748.0401 2022-04-15T06:23:49Z Abstract Aims Heart failure (HF) is an increasingly important contributor to the overall burden of cardiovascular disease in the population. We aimed to determine the distribution of the cardiac biomarkers high-sensitivity cardiac troponin I (hs-cTnI) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations across the European population to characterize the association with incident HF. Methods and results Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE)-project, we analysed data of 48,455 individuals from four prospective population-based cohort studies (DanMONICA, FINRISK, Moli-Sani, Northern Sweden MONICA study) across Europe with a maximum follow-up of 27 years. The median age of the participants was 50.7 years (25th percentile: 40.0 years, 75th percentile: 61.7 years) and 49.1% (25,146) were men. Considered endpoints were incident HF and all-cause mortality. The median follow-up time for occurrence of HF was 6.61 (6.55; 6.66) years. We found that cardiovascular risk factors (CVRFs), especially diabetes with HR of 2.11 (95% CI 1.8, 2.5) and smoking status with HR of 1.79 (95% CI 1.59, 2.1) (Figure 1) were associated with incident HF. Furthermore, beyond the CVRFs, elevated hs-cTnI and NT-proBNP concentrations contributed to risk of HF in the general population with HR of 1.49 (95% CI 1.21, 1.9) and HR of 2.37 (95% CI 1.97, 3.0) respectively. As a cut-off value to select individuals, who would benefit most from preventive strategies, a hs-cTnI concentration of 2.8 ng/L was calculated using the optimal cut-off methodology by Contal and O'Quigley in CSDA 1999. Hazard ratio for incident HF Conclusion In our large population-based cohort, hs-cTnI and NT-proBNP were independently associated with incident HF. Use of biomarkers for HF screening thus may help to select those individuals in the general population who would benefit most from preventive strategies. Based on the cut-off value future studies are needed to evaluate therapeutic options. Article in Journal/Newspaper Northern Sweden Oxford University Press (via Crossref) Moli ENVELOPE(19.182,19.182,69.227,69.227) European Heart Journal 40 Supplement_1 |
institution |
Open Polar |
collection |
Oxford University Press (via Crossref) |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Cardiology and Cardiovascular Medicine |
spellingShingle |
Cardiology and Cardiovascular Medicine Yan, I Boerschel, C Neumann, J Spruenker, N Kontto, J Kuulasmaa, K Salomaa, V Iacoviello, L Di Castelnuovo, A Costanzo, S Linneberg, A Soederberg, S Zeller, T Blankenberg, S Westermann, D P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population |
topic_facet |
Cardiology and Cardiovascular Medicine |
description |
Abstract Aims Heart failure (HF) is an increasingly important contributor to the overall burden of cardiovascular disease in the population. We aimed to determine the distribution of the cardiac biomarkers high-sensitivity cardiac troponin I (hs-cTnI) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations across the European population to characterize the association with incident HF. Methods and results Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE)-project, we analysed data of 48,455 individuals from four prospective population-based cohort studies (DanMONICA, FINRISK, Moli-Sani, Northern Sweden MONICA study) across Europe with a maximum follow-up of 27 years. The median age of the participants was 50.7 years (25th percentile: 40.0 years, 75th percentile: 61.7 years) and 49.1% (25,146) were men. Considered endpoints were incident HF and all-cause mortality. The median follow-up time for occurrence of HF was 6.61 (6.55; 6.66) years. We found that cardiovascular risk factors (CVRFs), especially diabetes with HR of 2.11 (95% CI 1.8, 2.5) and smoking status with HR of 1.79 (95% CI 1.59, 2.1) (Figure 1) were associated with incident HF. Furthermore, beyond the CVRFs, elevated hs-cTnI and NT-proBNP concentrations contributed to risk of HF in the general population with HR of 1.49 (95% CI 1.21, 1.9) and HR of 2.37 (95% CI 1.97, 3.0) respectively. As a cut-off value to select individuals, who would benefit most from preventive strategies, a hs-cTnI concentration of 2.8 ng/L was calculated using the optimal cut-off methodology by Contal and O'Quigley in CSDA 1999. Hazard ratio for incident HF Conclusion In our large population-based cohort, hs-cTnI and NT-proBNP were independently associated with incident HF. Use of biomarkers for HF screening thus may help to select those individuals in the general population who would benefit most from preventive strategies. Based on the cut-off value future studies are needed to evaluate therapeutic options. |
format |
Article in Journal/Newspaper |
author |
Yan, I Boerschel, C Neumann, J Spruenker, N Kontto, J Kuulasmaa, K Salomaa, V Iacoviello, L Di Castelnuovo, A Costanzo, S Linneberg, A Soederberg, S Zeller, T Blankenberg, S Westermann, D |
author_facet |
Yan, I Boerschel, C Neumann, J Spruenker, N Kontto, J Kuulasmaa, K Salomaa, V Iacoviello, L Di Castelnuovo, A Costanzo, S Linneberg, A Soederberg, S Zeller, T Blankenberg, S Westermann, D |
author_sort |
Yan, I |
title |
P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population |
title_short |
P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population |
title_full |
P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population |
title_fullStr |
P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population |
title_full_unstemmed |
P1642High-sensitivity cardiac troponin I and NT-proBNP and their relationship to heart failure in the European BiomarCaRE population |
title_sort |
p1642high-sensitivity cardiac troponin i and nt-probnp and their relationship to heart failure in the european biomarcare population |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1093/eurheartj/ehz748.0401 http://academic.oup.com/eurheartj/article-pdf/40/Supplement_1/ehz748.0401/30201771/ehz748.0401.pdf |
long_lat |
ENVELOPE(19.182,19.182,69.227,69.227) |
geographic |
Moli |
geographic_facet |
Moli |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
European Heart Journal volume 40, issue Supplement_1 ISSN 0195-668X 1522-9645 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/eurheartj/ehz748.0401 |
container_title |
European Heart Journal |
container_volume |
40 |
container_issue |
Supplement_1 |
_version_ |
1766148036973559808 |