P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease
Abstract Background Vitamin D has been implicated in the pathogenesis of inflammatory bowel disease (IBD), suggested by a geographical north-south gradient in risk for IBD. IBD patients have also been shown to have lower 25(OH) vitamin D (25(OH)D3) compared to healthy subjects. In contrast, prospect...
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croxfordunivpr:10.1093/ecco-jcc/jjab232.782 2023-05-15T17:44:35+02:00 P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease Widbom, L Fahlander, S Stefansson, K Karling, P Hultdin, J 2022 http://dx.doi.org/10.1093/ecco-jcc/jjab232.782 https://academic.oup.com/ecco-jcc/article-pdf/16/Supplement_1/i571/42252736/jjab232.782.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Journal of Crohn's and Colitis volume 16, issue Supplement_1, page i571-i572 ISSN 1873-9946 1876-4479 Gastroenterology General Medicine journal-article 2022 croxfordunivpr https://doi.org/10.1093/ecco-jcc/jjab232.782 2022-04-15T06:20:00Z Abstract Background Vitamin D has been implicated in the pathogenesis of inflammatory bowel disease (IBD), suggested by a geographical north-south gradient in risk for IBD. IBD patients have also been shown to have lower 25(OH) vitamin D (25(OH)D3) compared to healthy subjects. In contrast, prospective studies on pre-diagnostic samples, including one with late-onset IBD (n=241), have not found any differences. The aim of our study was to study 25(OH)D3 levels in subjects later developing IBD, including late-onset cases. Methods In this nested case-control study, 171 individuals who later developed IBD and 337 controls (matched for age, sex, and time and place for inclusion) were included. The study population was included from the Northern Sweden Health and Disease Study (NSHDS), and the Northern Sweden Maternity Cohort (RUB). Both with the catchment area being above latitude 63°N (based in Umeå, Sweden). 25(OH)D3 concentrations were analysed with LC-MS/MS on plasma collected at least one year before IBD diagnosis and compared between cases and controls using conditional logistic regression. Results Results are shown in tables 1–3. Baseline characteristics are presented separately for NSHDS (Table 1) and RUB (Table 2). For NSHDS and RUB cases, median ages were 50.1 and 25.3 years respectively, and median 25(OH)D3 levels 52.9 and 52.3 nmol/L respectively. There were no differences compared to matched controls. Conditional logistic regression (Table 3) for vitamin D levels and risk for developing IBD were made for NSHDS and RUB separately and combined. It was also made separately for Ulcerative Colitis and Crohn’s disease. No differences were shown for the whole group, nor for any of the subgroups. Conclusion In pre-diagnostic samples, 25(OH)D3 did not differ between those who later developed IBD and controls. In subgroup analysis separately for RUB (including younger, female individuals) and NSHDS (including late-onset IBD), no differences were seen in either subgroup. This study supports previous findings indicating that vitamin D is not associated with the risk of developing IBD, including late-onset IBD, and that there is no evidence for early malabsorption of vitamin D. Article in Journal/Newspaper Northern Sweden Oxford University Press (via Crossref) Journal of Crohn's and Colitis 16 Supplement_1 i571 i572 |
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Open Polar |
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Oxford University Press (via Crossref) |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Gastroenterology General Medicine |
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Gastroenterology General Medicine Widbom, L Fahlander, S Stefansson, K Karling, P Hultdin, J P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease |
topic_facet |
Gastroenterology General Medicine |
description |
Abstract Background Vitamin D has been implicated in the pathogenesis of inflammatory bowel disease (IBD), suggested by a geographical north-south gradient in risk for IBD. IBD patients have also been shown to have lower 25(OH) vitamin D (25(OH)D3) compared to healthy subjects. In contrast, prospective studies on pre-diagnostic samples, including one with late-onset IBD (n=241), have not found any differences. The aim of our study was to study 25(OH)D3 levels in subjects later developing IBD, including late-onset cases. Methods In this nested case-control study, 171 individuals who later developed IBD and 337 controls (matched for age, sex, and time and place for inclusion) were included. The study population was included from the Northern Sweden Health and Disease Study (NSHDS), and the Northern Sweden Maternity Cohort (RUB). Both with the catchment area being above latitude 63°N (based in Umeå, Sweden). 25(OH)D3 concentrations were analysed with LC-MS/MS on plasma collected at least one year before IBD diagnosis and compared between cases and controls using conditional logistic regression. Results Results are shown in tables 1–3. Baseline characteristics are presented separately for NSHDS (Table 1) and RUB (Table 2). For NSHDS and RUB cases, median ages were 50.1 and 25.3 years respectively, and median 25(OH)D3 levels 52.9 and 52.3 nmol/L respectively. There were no differences compared to matched controls. Conditional logistic regression (Table 3) for vitamin D levels and risk for developing IBD were made for NSHDS and RUB separately and combined. It was also made separately for Ulcerative Colitis and Crohn’s disease. No differences were shown for the whole group, nor for any of the subgroups. Conclusion In pre-diagnostic samples, 25(OH)D3 did not differ between those who later developed IBD and controls. In subgroup analysis separately for RUB (including younger, female individuals) and NSHDS (including late-onset IBD), no differences were seen in either subgroup. This study supports previous findings indicating that vitamin D is not associated with the risk of developing IBD, including late-onset IBD, and that there is no evidence for early malabsorption of vitamin D. |
format |
Article in Journal/Newspaper |
author |
Widbom, L Fahlander, S Stefansson, K Karling, P Hultdin, J |
author_facet |
Widbom, L Fahlander, S Stefansson, K Karling, P Hultdin, J |
author_sort |
Widbom, L |
title |
P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease |
title_short |
P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease |
title_full |
P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease |
title_fullStr |
P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease |
title_full_unstemmed |
P661 Pre-diagnostic vitamin D levels in Inflammatory Bowel Disease |
title_sort |
p661 pre-diagnostic vitamin d levels in inflammatory bowel disease |
publisher |
Oxford University Press (OUP) |
publishDate |
2022 |
url |
http://dx.doi.org/10.1093/ecco-jcc/jjab232.782 https://academic.oup.com/ecco-jcc/article-pdf/16/Supplement_1/i571/42252736/jjab232.782.pdf |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Crohn's and Colitis volume 16, issue Supplement_1, page i571-i572 ISSN 1873-9946 1876-4479 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/ecco-jcc/jjab232.782 |
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Journal of Crohn's and Colitis |
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16 |
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Supplement_1 |
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i571 |
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i572 |
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1766146837613379584 |