Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study
Abstract Background Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus, a bile duct–dwelling trematode liver fluke is highly endemic. Closely related species have been shown to be cancerogenic agents in...
Published in: | Clinical Infectious Diseases |
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2022
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Online Access: | http://dx.doi.org/10.1093/cid/ciac497 https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac497/45785685/ciac497.pdf https://academic.oup.com/cid/article-pdf/76/3/e1392/49125133/ciac497.pdf |
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croxfordunivpr:10.1093/cid/ciac497 2024-09-15T18:16:38+00:00 Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study Fedorova, Olga S Kovshirina, Anna E Kovshirina, Yulia V Hattendorf, Jan Onishchenko, Sergey V Katanakhova, Ludmila L Taslicki, Stanislav S Chizhikov, Andrey V Tataurov, Ilya A Vtorushin, Sergey V Sripa, Banchob Ogorodova, Ludmila M Odermatt, Peter Russian Foundation 2022 http://dx.doi.org/10.1093/cid/ciac497 https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac497/45785685/ciac497.pdf https://academic.oup.com/cid/article-pdf/76/3/e1392/49125133/ciac497.pdf en eng Oxford University Press (OUP) https://academic.oup.com/pages/standard-publication-reuse-rights Clinical Infectious Diseases volume 76, issue 3, page e1392-e1398 ISSN 1058-4838 1537-6591 journal-article 2022 croxfordunivpr https://doi.org/10.1093/cid/ciac497 2024-08-12T04:22:57Z Abstract Background Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus, a bile duct–dwelling trematode liver fluke is highly endemic. Closely related species have been shown to be cancerogenic agents in Asia. We therefore examined the association between O felineus infection and CCA in Western Siberia. Methods We conducted a hospital-based, individually matched case-control study between January 2017 and August 2020 in Tomsk Oblast and Khanty-Mansiysk Autonomous Okrug, Yugra, Russian Federation. Histologically confirmed CCA patients (cases) were compared with matched age, sex, and place of residence hospital controls. The examination of study participants included the diagnosis of current and past O felineus infection, abdominal ultrasonographical assessment, physical examination, and interview on exposures to potential risk factors. Results We identified 40 patients with CCA and 160 controls. Exposures to O felineus infection was strongly associated with CCA (odds ratio [OR], 3.9; 95% confidence interval [CI], 1.4–10.8; P = .008). Also, cases reported more often that they were currently or in the past were infected by O felineus compared with controls (OR, 4.03; 95% CI, 1.7–9.5; P = .001). Furthermore, cases reported river fish consumption and fishing habits significantly more often than controls (OR, 5.5; 95% CI, 1.5–19.8; P = .009 and OR, 3.3; 95% CI, 1.4–7.7; P = .005). Conclusions The study results revealed a strong significantly increased risk for CCA development in O felineus–infected individuals. Elaboration of the guidelines on screening programs for early CCA diagnosis, prevention, and treatment is socially important in endemic regions. Article in Journal/Newspaper khanty Siberia Oxford University Press Clinical Infectious Diseases |
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Oxford University Press |
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croxfordunivpr |
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English |
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Abstract Background Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus, a bile duct–dwelling trematode liver fluke is highly endemic. Closely related species have been shown to be cancerogenic agents in Asia. We therefore examined the association between O felineus infection and CCA in Western Siberia. Methods We conducted a hospital-based, individually matched case-control study between January 2017 and August 2020 in Tomsk Oblast and Khanty-Mansiysk Autonomous Okrug, Yugra, Russian Federation. Histologically confirmed CCA patients (cases) were compared with matched age, sex, and place of residence hospital controls. The examination of study participants included the diagnosis of current and past O felineus infection, abdominal ultrasonographical assessment, physical examination, and interview on exposures to potential risk factors. Results We identified 40 patients with CCA and 160 controls. Exposures to O felineus infection was strongly associated with CCA (odds ratio [OR], 3.9; 95% confidence interval [CI], 1.4–10.8; P = .008). Also, cases reported more often that they were currently or in the past were infected by O felineus compared with controls (OR, 4.03; 95% CI, 1.7–9.5; P = .001). Furthermore, cases reported river fish consumption and fishing habits significantly more often than controls (OR, 5.5; 95% CI, 1.5–19.8; P = .009 and OR, 3.3; 95% CI, 1.4–7.7; P = .005). Conclusions The study results revealed a strong significantly increased risk for CCA development in O felineus–infected individuals. Elaboration of the guidelines on screening programs for early CCA diagnosis, prevention, and treatment is socially important in endemic regions. |
author2 |
Russian Foundation |
format |
Article in Journal/Newspaper |
author |
Fedorova, Olga S Kovshirina, Anna E Kovshirina, Yulia V Hattendorf, Jan Onishchenko, Sergey V Katanakhova, Ludmila L Taslicki, Stanislav S Chizhikov, Andrey V Tataurov, Ilya A Vtorushin, Sergey V Sripa, Banchob Ogorodova, Ludmila M Odermatt, Peter |
spellingShingle |
Fedorova, Olga S Kovshirina, Anna E Kovshirina, Yulia V Hattendorf, Jan Onishchenko, Sergey V Katanakhova, Ludmila L Taslicki, Stanislav S Chizhikov, Andrey V Tataurov, Ilya A Vtorushin, Sergey V Sripa, Banchob Ogorodova, Ludmila M Odermatt, Peter Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study |
author_facet |
Fedorova, Olga S Kovshirina, Anna E Kovshirina, Yulia V Hattendorf, Jan Onishchenko, Sergey V Katanakhova, Ludmila L Taslicki, Stanislav S Chizhikov, Andrey V Tataurov, Ilya A Vtorushin, Sergey V Sripa, Banchob Ogorodova, Ludmila M Odermatt, Peter |
author_sort |
Fedorova, Olga S |
title |
Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study |
title_short |
Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study |
title_full |
Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study |
title_fullStr |
Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study |
title_full_unstemmed |
Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study |
title_sort |
opisthorchis felineus infection is a risk factor for cholangiocarcinoma in western siberia: a hospital-based case-control study |
publisher |
Oxford University Press (OUP) |
publishDate |
2022 |
url |
http://dx.doi.org/10.1093/cid/ciac497 https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac497/45785685/ciac497.pdf https://academic.oup.com/cid/article-pdf/76/3/e1392/49125133/ciac497.pdf |
genre |
khanty Siberia |
genre_facet |
khanty Siberia |
op_source |
Clinical Infectious Diseases volume 76, issue 3, page e1392-e1398 ISSN 1058-4838 1537-6591 |
op_rights |
https://academic.oup.com/pages/standard-publication-reuse-rights |
op_doi |
https://doi.org/10.1093/cid/ciac497 |
container_title |
Clinical Infectious Diseases |
_version_ |
1810454650143375360 |