Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis
ABSTRACT Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentra...
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croxfordunivpr:10.1093/advances/nmz120 2023-05-15T16:30:24+02:00 Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis Wu, Shenghui Liu, Yanning Michalek, Joel E Mesa, Ruben A Parma, Dorothy Long Rodriguez, Ronald Mansour, Ahmed M Svatek, Robert Tucker, Thomas C Ramirez, Amelie G 2019 http://dx.doi.org/10.1093/advances/nmz120 http://academic.oup.com/advances/article-pdf/11/3/630/33182855/nmz120.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Advances in Nutrition volume 11, issue 3, page 630-643 ISSN 2161-8313 2156-5376 Nutrition and Dietetics Medicine (miscellaneous) Food Science journal-article 2019 croxfordunivpr https://doi.org/10.1093/advances/nmz120 2022-12-29T15:39:56Z ABSTRACT Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95% CI: 0.76, 1.03) and 0.36 (95% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95% CI: 0.36, 0.94); by 76% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95% CI: 0.08, 0.67); by 27% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95% CI: 0.57, 0.94); and by 56% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240. Article in Journal/Newspaper Greenland Oxford University Press (via Crossref) Greenland Advances in Nutrition 11 3 630 643 |
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Oxford University Press (via Crossref) |
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croxfordunivpr |
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English |
topic |
Nutrition and Dietetics Medicine (miscellaneous) Food Science |
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Nutrition and Dietetics Medicine (miscellaneous) Food Science Wu, Shenghui Liu, Yanning Michalek, Joel E Mesa, Ruben A Parma, Dorothy Long Rodriguez, Ronald Mansour, Ahmed M Svatek, Robert Tucker, Thomas C Ramirez, Amelie G Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
topic_facet |
Nutrition and Dietetics Medicine (miscellaneous) Food Science |
description |
ABSTRACT Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95% CI: 0.76, 1.03) and 0.36 (95% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95% CI: 0.36, 0.94); by 76% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95% CI: 0.08, 0.67); by 27% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95% CI: 0.57, 0.94); and by 56% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240. |
format |
Article in Journal/Newspaper |
author |
Wu, Shenghui Liu, Yanning Michalek, Joel E Mesa, Ruben A Parma, Dorothy Long Rodriguez, Ronald Mansour, Ahmed M Svatek, Robert Tucker, Thomas C Ramirez, Amelie G |
author_facet |
Wu, Shenghui Liu, Yanning Michalek, Joel E Mesa, Ruben A Parma, Dorothy Long Rodriguez, Ronald Mansour, Ahmed M Svatek, Robert Tucker, Thomas C Ramirez, Amelie G |
author_sort |
Wu, Shenghui |
title |
Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
title_short |
Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
title_full |
Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
title_fullStr |
Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
title_full_unstemmed |
Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
title_sort |
carotenoid intake and circulating carotenoids are inversely associated with the risk of bladder cancer: a dose-response meta-analysis |
publisher |
Oxford University Press (OUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1093/advances/nmz120 http://academic.oup.com/advances/article-pdf/11/3/630/33182855/nmz120.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Advances in Nutrition volume 11, issue 3, page 630-643 ISSN 2161-8313 2156-5376 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/advances/nmz120 |
container_title |
Advances in Nutrition |
container_volume |
11 |
container_issue |
3 |
container_start_page |
630 |
op_container_end_page |
643 |
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1766020129726922752 |