Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods

ABSTRACT Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of t...

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Published in:Bioscience, Biotechnology, and Biochemistry
Main Authors: Ding, Jing, Yang, Zhijun, Zhao, Yu, Fang, Weizhen, Lu, Qun
Other Authors: Fundamental Research Funds for the Central Universities under Grant
Format: Article in Journal/Newspaper
Language:English
Published: Oxford University Press (OUP) 2019
Subjects:
Organic Chemistry
Molecular Biology
Applied Microbiology and Biotechnology
General Medicine
Biochemistry
Analytical Chemistry
Biotechnology
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1080/09168451.2018.1554426
http://academic.oup.com/bbb/article-pdf/83/4/763/36825767/bbb0763.pdf
id croxfordunivpr:10.1080/09168451.2018.1554426
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spelling croxfordunivpr:10.1080/09168451.2018.1554426 2023-05-15T14:08:27+02:00 Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods Ding, Jing Yang, Zhijun Zhao, Yu Fang, Weizhen Lu, Qun Fundamental Research Funds for the Central Universities under Grant 2019 http://dx.doi.org/10.1080/09168451.2018.1554426 http://academic.oup.com/bbb/article-pdf/83/4/763/36825767/bbb0763.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model Bioscience, Biotechnology, and Biochemistry volume 83, issue 4, page 763-767 ISSN 0916-8451 1347-6947 Organic Chemistry Molecular Biology Applied Microbiology and Biotechnology General Medicine Biochemistry Analytical Chemistry Biotechnology journal-article 2019 croxfordunivpr https://doi.org/10.1080/09168451.2018.1554426 2022-04-15T06:16:06Z ABSTRACT Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester. Article in Journal/Newspaper Antarc* Antarctica Oxford University Press (via Crossref) Bioscience, Biotechnology, and Biochemistry 83 4 763 767
institution Open Polar
collection Oxford University Press (via Crossref)
op_collection_id croxfordunivpr
language English
topic Organic Chemistry
Molecular Biology
Applied Microbiology and Biotechnology
General Medicine
Biochemistry
Analytical Chemistry
Biotechnology
spellingShingle Organic Chemistry
Molecular Biology
Applied Microbiology and Biotechnology
General Medicine
Biochemistry
Analytical Chemistry
Biotechnology
Ding, Jing
Yang, Zhijun
Zhao, Yu
Fang, Weizhen
Lu, Qun
Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
topic_facet Organic Chemistry
Molecular Biology
Applied Microbiology and Biotechnology
General Medicine
Biochemistry
Analytical Chemistry
Biotechnology
description ABSTRACT Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester.
author2 Fundamental Research Funds for the Central Universities under Grant
format Article in Journal/Newspaper
author Ding, Jing
Yang, Zhijun
Zhao, Yu
Fang, Weizhen
Lu, Qun
author_facet Ding, Jing
Yang, Zhijun
Zhao, Yu
Fang, Weizhen
Lu, Qun
author_sort Ding, Jing
title Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
title_short Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
title_full Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
title_fullStr Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
title_full_unstemmed Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
title_sort lipase-catalyzed synthesis of ethyl ( r )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
publisher Oxford University Press (OUP)
publishDate 2019
url http://dx.doi.org/10.1080/09168451.2018.1554426
http://academic.oup.com/bbb/article-pdf/83/4/763/36825767/bbb0763.pdf
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_source Bioscience, Biotechnology, and Biochemistry
volume 83, issue 4, page 763-767
ISSN 0916-8451 1347-6947
op_rights https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
op_doi https://doi.org/10.1080/09168451.2018.1554426
container_title Bioscience, Biotechnology, and Biochemistry
container_volume 83
container_issue 4
container_start_page 763
op_container_end_page 767
_version_ 1766280484795449344

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