Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice
Abstract Peritoneal inflammation is a convenient model for comparisons of modulatory effects of morphine in phylogenetically distant vertebrates. Both in salmon and mice morphine injected intraperitoneally together with an irritant (thioglycollate) significantly inhibits inflammation as estimated by...
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Oxford University Press (OUP)
1999
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croxfordunivpr:10.1002/jlb.65.5.590 2024-06-23T07:51:22+00:00 Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice Chadzinska, M Kolaczkowska, E Seljelid, R Plytycz, B 1999 http://dx.doi.org/10.1002/jlb.65.5.590 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjlb.65.5.590 https://academic.oup.com/jleukbio/article-pdf/65/5/590/49731816/jlb0590.pdf en eng Oxford University Press (OUP) https://academic.oup.com/pages/standard-publication-reuse-rights Journal of Leukocyte Biology volume 65, issue 5, page 590-596 ISSN 0741-5400 1938-3673 journal-article 1999 croxfordunivpr https://doi.org/10.1002/jlb.65.5.590 2024-06-11T04:18:23Z Abstract Peritoneal inflammation is a convenient model for comparisons of modulatory effects of morphine in phylogenetically distant vertebrates. Both in salmon and mice morphine injected intraperitoneally together with an irritant (thioglycollate) significantly inhibits inflammation as estimated by the number of peritoneal leukocytes. The low number of exudate cells in morphine-treated animals seems to be compensated by their high activity, as evidenced by the enhanced phorbol myristate acetate-induced respiratory burst. The morphine-inhibited influx of leukocytes into the irritated peritoneal cavity correlates with the morphine-lowered level of plasma chemotactic factors both in fish and mice. It implies that morphine impairs the level of plasma chemotactic factor either directly (affecting their release from the resident peritoneal cells) or indirectly (decreasing the number of inflammatory leukocytes by inhibition of their migration from hemopoietic sites). The inhibitory effects of morphine on both the cell number and chemoattractant level are completely reversed by the naltrexone pretreatment, which implicates the involvement of opioid receptors. J. Leukoc. Biol. 65: 590–596; 1999. Article in Journal/Newspaper Atlantic salmon Oxford University Press Journal of Leukocyte Biology 65 5 590 596 |
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Open Polar |
collection |
Oxford University Press |
op_collection_id |
croxfordunivpr |
language |
English |
description |
Abstract Peritoneal inflammation is a convenient model for comparisons of modulatory effects of morphine in phylogenetically distant vertebrates. Both in salmon and mice morphine injected intraperitoneally together with an irritant (thioglycollate) significantly inhibits inflammation as estimated by the number of peritoneal leukocytes. The low number of exudate cells in morphine-treated animals seems to be compensated by their high activity, as evidenced by the enhanced phorbol myristate acetate-induced respiratory burst. The morphine-inhibited influx of leukocytes into the irritated peritoneal cavity correlates with the morphine-lowered level of plasma chemotactic factors both in fish and mice. It implies that morphine impairs the level of plasma chemotactic factor either directly (affecting their release from the resident peritoneal cells) or indirectly (decreasing the number of inflammatory leukocytes by inhibition of their migration from hemopoietic sites). The inhibitory effects of morphine on both the cell number and chemoattractant level are completely reversed by the naltrexone pretreatment, which implicates the involvement of opioid receptors. J. Leukoc. Biol. 65: 590–596; 1999. |
format |
Article in Journal/Newspaper |
author |
Chadzinska, M Kolaczkowska, E Seljelid, R Plytycz, B |
spellingShingle |
Chadzinska, M Kolaczkowska, E Seljelid, R Plytycz, B Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice |
author_facet |
Chadzinska, M Kolaczkowska, E Seljelid, R Plytycz, B |
author_sort |
Chadzinska, M |
title |
Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice |
title_short |
Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice |
title_full |
Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice |
title_fullStr |
Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice |
title_full_unstemmed |
Morphine modulation of peritoneal inflammation in Atlantic salmon and CB6 mice |
title_sort |
morphine modulation of peritoneal inflammation in atlantic salmon and cb6 mice |
publisher |
Oxford University Press (OUP) |
publishDate |
1999 |
url |
http://dx.doi.org/10.1002/jlb.65.5.590 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjlb.65.5.590 https://academic.oup.com/jleukbio/article-pdf/65/5/590/49731816/jlb0590.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Journal of Leukocyte Biology volume 65, issue 5, page 590-596 ISSN 0741-5400 1938-3673 |
op_rights |
https://academic.oup.com/pages/standard-publication-reuse-rights |
op_doi |
https://doi.org/10.1002/jlb.65.5.590 |
container_title |
Journal of Leukocyte Biology |
container_volume |
65 |
container_issue |
5 |
container_start_page |
590 |
op_container_end_page |
596 |
_version_ |
1802642454180003840 |