Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study

BACKGROUND: Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young a...

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Published in:Stroke
Main Authors: Mikkola, Ursula, Rissanen, Ina, Kivelä, Milja, Rusanen, Harri, Kajantie, Eero, Miettunen, Jouko, Paananen, Markus
Format: Article in Journal/Newspaper
Language:English
Published: Ovid Technologies (Wolters Kluwer Health) 2024
Subjects:
Online Access:http://dx.doi.org/10.1161/strokeaha.123.045444
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.123.045444
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spelling crovidcr:10.1161/strokeaha.123.045444 2024-09-15T18:25:43+00:00 Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study Mikkola, Ursula Rissanen, Ina Kivelä, Milja Rusanen, Harri Kajantie, Eero Miettunen, Jouko Paananen, Markus 2024 http://dx.doi.org/10.1161/strokeaha.123.045444 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.123.045444 en eng Ovid Technologies (Wolters Kluwer Health) https://creativecommons.org/licenses/by/4.0/ Stroke volume 55, issue 7, page 1857-1865 ISSN 0039-2499 1524-4628 journal-article 2024 crovidcr https://doi.org/10.1161/strokeaha.123.045444 2024-07-29T04:17:04Z BACKGROUND: Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young adulthood on early onset cerebrovascular disease. METHODS: This study includes 10 491 people (5185 women) from the Northern Finland Birth Cohort 1966. Height, weight, and BMI were measured at ages 14 and 31 years. Sex- and age-specific BMI ranges were used to define overweight and obesity. Data on ischemic and hemorrhagic cerebrovascular diseases between ages 14 and 54 years were extracted from national hospital and death registers. Cox proportion hazard models (95% CI) were used to estimate associations between BMI or its changes and cerebrovascular disease, while adjusting for sex, smoking, educational level, BMI at the other time point, and age at menarche for women. Additionally, sex-BMI interactions were calculated. RESULTS: A total of 452 individuals (4.7%) experienced cerebrovascular disease during the follow-up. The risk of ischemic cerebrovascular disease was increased for overweight women at ages 14 years (hazard ratio [HR], 2.49 [95% CI, 1.44–4.31]) and 31 years (HR, 2.13 [95% CI, 1.14–3.97]), as well as for obese women at ages 14 years (HR, 1.87 [95% CI, 0.76–4.58) and 31 years (HR, 2.67 [95% CI, 1.26–5.65]), with normal weight as the reference. These results were independent of earlier or later BMI. Similar associations were not found among men. The risk of hemorrhagic cerebrovascular disease was increased at age 31 years both among obese women (HR, 3.49 [95% CI, 1.13–10.7) and obese men (HR, 5.75 [95% CI, 1.43–23.1). The risk of any cerebrovascular disease related to overweight at age 14 years was 2.09× higher among girls than boys (95% CI, 1.06–4.15). The risk of ischemic cerebrovascular disease related to obesity at age 31 years was 6.96× higher among women than men (95% CI, 1.36–35.7). CONCLUSIONS: ... Article in Journal/Newspaper Northern Finland Ovid Stroke
institution Open Polar
collection Ovid
op_collection_id crovidcr
language English
description BACKGROUND: Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young adulthood on early onset cerebrovascular disease. METHODS: This study includes 10 491 people (5185 women) from the Northern Finland Birth Cohort 1966. Height, weight, and BMI were measured at ages 14 and 31 years. Sex- and age-specific BMI ranges were used to define overweight and obesity. Data on ischemic and hemorrhagic cerebrovascular diseases between ages 14 and 54 years were extracted from national hospital and death registers. Cox proportion hazard models (95% CI) were used to estimate associations between BMI or its changes and cerebrovascular disease, while adjusting for sex, smoking, educational level, BMI at the other time point, and age at menarche for women. Additionally, sex-BMI interactions were calculated. RESULTS: A total of 452 individuals (4.7%) experienced cerebrovascular disease during the follow-up. The risk of ischemic cerebrovascular disease was increased for overweight women at ages 14 years (hazard ratio [HR], 2.49 [95% CI, 1.44–4.31]) and 31 years (HR, 2.13 [95% CI, 1.14–3.97]), as well as for obese women at ages 14 years (HR, 1.87 [95% CI, 0.76–4.58) and 31 years (HR, 2.67 [95% CI, 1.26–5.65]), with normal weight as the reference. These results were independent of earlier or later BMI. Similar associations were not found among men. The risk of hemorrhagic cerebrovascular disease was increased at age 31 years both among obese women (HR, 3.49 [95% CI, 1.13–10.7) and obese men (HR, 5.75 [95% CI, 1.43–23.1). The risk of any cerebrovascular disease related to overweight at age 14 years was 2.09× higher among girls than boys (95% CI, 1.06–4.15). The risk of ischemic cerebrovascular disease related to obesity at age 31 years was 6.96× higher among women than men (95% CI, 1.36–35.7). CONCLUSIONS: ...
format Article in Journal/Newspaper
author Mikkola, Ursula
Rissanen, Ina
Kivelä, Milja
Rusanen, Harri
Kajantie, Eero
Miettunen, Jouko
Paananen, Markus
spellingShingle Mikkola, Ursula
Rissanen, Ina
Kivelä, Milja
Rusanen, Harri
Kajantie, Eero
Miettunen, Jouko
Paananen, Markus
Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study
author_facet Mikkola, Ursula
Rissanen, Ina
Kivelä, Milja
Rusanen, Harri
Kajantie, Eero
Miettunen, Jouko
Paananen, Markus
author_sort Mikkola, Ursula
title Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study
title_short Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study
title_full Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study
title_fullStr Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study
title_full_unstemmed Overweight in Adolescence and Young Adulthood in Association With Adult Cerebrovascular Disease: The NFBC1966 Study
title_sort overweight in adolescence and young adulthood in association with adult cerebrovascular disease: the nfbc1966 study
publisher Ovid Technologies (Wolters Kluwer Health)
publishDate 2024
url http://dx.doi.org/10.1161/strokeaha.123.045444
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.123.045444
genre Northern Finland
genre_facet Northern Finland
op_source Stroke
volume 55, issue 7, page 1857-1865
ISSN 0039-2499 1524-4628
op_rights https://creativecommons.org/licenses/by/4.0/
op_doi https://doi.org/10.1161/strokeaha.123.045444
container_title Stroke
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