Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study
Background and Purpose: Data on long-term survival after intracerebral hemorrhage (ICH) are scarce. In a population-based nested case-control study, we compared long-term survival and causes of death within 5 years in 30-day survivors of first-ever ICH and controls, assessed the impact of cardiovasc...
Published in: | Stroke |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Ovid Technologies (Wolters Kluwer Health)
2021
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1161/strokeaha.120.032750 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.032750 |
id |
crovidcr:10.1161/strokeaha.120.032750 |
---|---|
record_format |
openpolar |
spelling |
crovidcr:10.1161/strokeaha.120.032750 2024-05-19T07:49:33+00:00 Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. 2021 http://dx.doi.org/10.1161/strokeaha.120.032750 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.032750 en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 52, issue 12, page 3883-3890 ISSN 0039-2499 1524-4628 journal-article 2021 crovidcr https://doi.org/10.1161/strokeaha.120.032750 2024-05-02T09:28:35Z Background and Purpose: Data on long-term survival after intracerebral hemorrhage (ICH) are scarce. In a population-based nested case-control study, we compared long-term survival and causes of death within 5 years in 30-day survivors of first-ever ICH and controls, assessed the impact of cardiovascular risk factors on 5-year mortality, and analyzed time trend in 5-year mortality in ICH patients over 2 decades. Methods: We included 219 participants from the population-based Tromsø Study, who after the baseline participation had a first-ever ICH between 1994 to 2013 and 1095 age- and sex-matched participants without ICH. Cumulative survival was presented using the Kaplan-Meier method. Hazard ratios (HRs) for mortality and for the association between cardiovascular risk factors and 5-year mortality in 30-day survivors were estimated by stratified Cox proportional hazards models. Trend in 5-year mortality was assessed by logistic regression. Results: Risk of death during follow-up (median time, 4.8 years) was increased in the ICH group compared with controls (HR, 1.62 [95% CI, 1.27–2.06]). Cardiovascular disease was the leading cause of death, with a higher proportion in ICH patients (22.9% versus 9.0%; P <0.001). Smoking increased the risk of 5-year mortality in cases and controls (HR, 1.59 [95% CI, 1.15–2.19]), whereas serum cholesterol was associated with 5-year mortality in cases only (HR, 1.39 [95% CI, 1.04–1.86]). Use of anticoagulants at ICH onset increased the risk of death (HR, 2.09 [95% CI, 1.09–4.00]). There was no difference according to ICH location (HR, 1.15 [95% CI, 0.56–2.37]). Five-year mortality did not change during the study period (odds ratio per calendar year, 1.01 [95% CI, 0.93–1.09]). Conclusions: Survival rates were significantly lower in cases than in controls, driven by a 2-fold increased risk of cardiovascular death. Smoking, serum cholesterol, and use of anticoagulant drugs were associated with increased risk of death in ICH patients. Five-year mortality rates in ICH patients ... Article in Journal/Newspaper Tromsø Ovid Stroke |
institution |
Open Polar |
collection |
Ovid |
op_collection_id |
crovidcr |
language |
English |
description |
Background and Purpose: Data on long-term survival after intracerebral hemorrhage (ICH) are scarce. In a population-based nested case-control study, we compared long-term survival and causes of death within 5 years in 30-day survivors of first-ever ICH and controls, assessed the impact of cardiovascular risk factors on 5-year mortality, and analyzed time trend in 5-year mortality in ICH patients over 2 decades. Methods: We included 219 participants from the population-based Tromsø Study, who after the baseline participation had a first-ever ICH between 1994 to 2013 and 1095 age- and sex-matched participants without ICH. Cumulative survival was presented using the Kaplan-Meier method. Hazard ratios (HRs) for mortality and for the association between cardiovascular risk factors and 5-year mortality in 30-day survivors were estimated by stratified Cox proportional hazards models. Trend in 5-year mortality was assessed by logistic regression. Results: Risk of death during follow-up (median time, 4.8 years) was increased in the ICH group compared with controls (HR, 1.62 [95% CI, 1.27–2.06]). Cardiovascular disease was the leading cause of death, with a higher proportion in ICH patients (22.9% versus 9.0%; P <0.001). Smoking increased the risk of 5-year mortality in cases and controls (HR, 1.59 [95% CI, 1.15–2.19]), whereas serum cholesterol was associated with 5-year mortality in cases only (HR, 1.39 [95% CI, 1.04–1.86]). Use of anticoagulants at ICH onset increased the risk of death (HR, 2.09 [95% CI, 1.09–4.00]). There was no difference according to ICH location (HR, 1.15 [95% CI, 0.56–2.37]). Five-year mortality did not change during the study period (odds ratio per calendar year, 1.01 [95% CI, 0.93–1.09]). Conclusions: Survival rates were significantly lower in cases than in controls, driven by a 2-fold increased risk of cardiovascular death. Smoking, serum cholesterol, and use of anticoagulant drugs were associated with increased risk of death in ICH patients. Five-year mortality rates in ICH patients ... |
format |
Article in Journal/Newspaper |
author |
Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. |
spellingShingle |
Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study |
author_facet |
Carlsson, Maria Wilsgaard, Tom Johnsen, Stein Harald Johnsen, Liv-Hege Løchen, Maja-Lisa Njølstad, Inger Mathiesen, Ellisiv B. |
author_sort |
Carlsson, Maria |
title |
Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study |
title_short |
Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study |
title_full |
Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study |
title_fullStr |
Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study |
title_full_unstemmed |
Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study |
title_sort |
long-term survival, causes of death, and trends in 5-year mortality after intracerebral hemorrhage: the tromsø study |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1161/strokeaha.120.032750 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.032750 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Stroke volume 52, issue 12, page 3883-3890 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/strokeaha.120.032750 |
container_title |
Stroke |
_version_ |
1799468050106286080 |