Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage
Background and Purpose: Previous observational studies have shown a moderately increased risk of intracerebral hemorrhage (ICH) with high self-reported alcohol consumption. However, self-reported data tend to underestimate alcohol consumption. Phosphatidylethanol is a specific biomarker reflecting a...
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Ovid Technologies (Wolters Kluwer Health)
2020
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Online Access: | http://dx.doi.org/10.1161/strokeaha.120.029630 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.029630 |
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crovidcr:10.1161/strokeaha.120.029630 2024-06-23T07:55:38+00:00 Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage Johansson, Kristina Johansson, Lars Pennlert, Johanna Söderberg, Stefan Jansson, Jan-Håkan Lind, Marcus M. 2020 http://dx.doi.org/10.1161/strokeaha.120.029630 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.029630 en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 51, issue 7, page 2148-2152 ISSN 0039-2499 1524-4628 journal-article 2020 crovidcr https://doi.org/10.1161/strokeaha.120.029630 2024-06-04T06:02:22Z Background and Purpose: Previous observational studies have shown a moderately increased risk of intracerebral hemorrhage (ICH) with high self-reported alcohol consumption. However, self-reported data tend to underestimate alcohol consumption. Phosphatidylethanol is a specific biomarker reflecting alcohol intake during the last month and correlates with the amount of alcohol consumed. The present study aimed to investigate the association between phosphatidylethanol levels and the risk of future ICH. Methods: This population-based nested case-referent study was conducted within the Northern Sweden Health and Disease Cohort. At baseline, all participants underwent a health examination, including a questionnaire with questions about alcohol consumption. A blood sample was collected and stored at −80°C, and phosphatidylethanol 16:0/18:1 levels were measured in packed erythrocytes. Cases (n=97) were diagnosed with a first-ever ICH between 1985 and 2007. Two referents (n=180) were matched to each case. Results: The mean age at baseline was 55 years, 39% of participants were women, and the mean time from blood sampling to ICH was 7.3 years. Only phosphatidylethanol and hypertension remained independently associated with ICH in a multivariable model. Participants with phosphatidylethanol >0.30 μmol/L had an increased risk of ICH compared with those with phosphatidylethanol <0.01 μmol/L (odds ratio, 4.64 [95% CI, 1.49–14.40]). Conclusions: High blood concentrations of phosphatidylethanol were associated with an increased risk of future ICH. This association was independent of hypertension and other risk factors for ICH. Our findings suggest that phosphatidylethanol, as a marker of alcohol consumption, may be used as a risk marker of future ICH. Article in Journal/Newspaper Northern Sweden Ovid Stroke 51 7 2148 2152 |
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Background and Purpose: Previous observational studies have shown a moderately increased risk of intracerebral hemorrhage (ICH) with high self-reported alcohol consumption. However, self-reported data tend to underestimate alcohol consumption. Phosphatidylethanol is a specific biomarker reflecting alcohol intake during the last month and correlates with the amount of alcohol consumed. The present study aimed to investigate the association between phosphatidylethanol levels and the risk of future ICH. Methods: This population-based nested case-referent study was conducted within the Northern Sweden Health and Disease Cohort. At baseline, all participants underwent a health examination, including a questionnaire with questions about alcohol consumption. A blood sample was collected and stored at −80°C, and phosphatidylethanol 16:0/18:1 levels were measured in packed erythrocytes. Cases (n=97) were diagnosed with a first-ever ICH between 1985 and 2007. Two referents (n=180) were matched to each case. Results: The mean age at baseline was 55 years, 39% of participants were women, and the mean time from blood sampling to ICH was 7.3 years. Only phosphatidylethanol and hypertension remained independently associated with ICH in a multivariable model. Participants with phosphatidylethanol >0.30 μmol/L had an increased risk of ICH compared with those with phosphatidylethanol <0.01 μmol/L (odds ratio, 4.64 [95% CI, 1.49–14.40]). Conclusions: High blood concentrations of phosphatidylethanol were associated with an increased risk of future ICH. This association was independent of hypertension and other risk factors for ICH. Our findings suggest that phosphatidylethanol, as a marker of alcohol consumption, may be used as a risk marker of future ICH. |
format |
Article in Journal/Newspaper |
author |
Johansson, Kristina Johansson, Lars Pennlert, Johanna Söderberg, Stefan Jansson, Jan-Håkan Lind, Marcus M. |
spellingShingle |
Johansson, Kristina Johansson, Lars Pennlert, Johanna Söderberg, Stefan Jansson, Jan-Håkan Lind, Marcus M. Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage |
author_facet |
Johansson, Kristina Johansson, Lars Pennlert, Johanna Söderberg, Stefan Jansson, Jan-Håkan Lind, Marcus M. |
author_sort |
Johansson, Kristina |
title |
Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage |
title_short |
Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage |
title_full |
Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage |
title_fullStr |
Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage |
title_full_unstemmed |
Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage |
title_sort |
phosphatidylethanol levels, as a marker of alcohol consumption, are associated with risk of intracerebral hemorrhage |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2020 |
url |
http://dx.doi.org/10.1161/strokeaha.120.029630 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.029630 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Stroke volume 51, issue 7, page 2148-2152 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/strokeaha.120.029630 |
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Stroke |
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51 |
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7 |
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2148 |
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2152 |
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1802648291022733312 |