Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden
Background and Purpose— Natural immunoglobulin M antibodies specific for phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown previously that high levels of anti-PC predict a slower progression of atherosclerosis in humans and that low levels of anti-PC are associated w...
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Online Access: | http://dx.doi.org/10.1161/strokeaha.109.558742 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.109.558742 |
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crovidcr:10.1161/strokeaha.109.558742 2024-06-23T07:55:36+00:00 Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden Fiskesund, Roland Stegmayr, Birgitta Hallmans, Göran Vikström, Max Weinehall, Lars de Faire, Ulf Frostegård, Johan 2010 http://dx.doi.org/10.1161/strokeaha.109.558742 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.109.558742 en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 41, issue 4, page 607-612 ISSN 0039-2499 1524-4628 journal-article 2010 crovidcr https://doi.org/10.1161/strokeaha.109.558742 2024-05-24T13:21:18Z Background and Purpose— Natural immunoglobulin M antibodies specific for phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown previously that high levels of anti-PC predict a slower progression of atherosclerosis in humans and that low levels of anti-PC are associated with higher risk for cardiovascular disease. Here we determine the association between anti-PC and the incidence of stroke. Methods— Using a nested case control study design, we examined 227 incident cases (125 men and 102 women) of first-time stroke and 455 age- and sex-matched controls identified during a 13-year time period (1985 to 1999) within the population-based cohorts of the Västerbotten Intervention Project (VIP) and the World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease (WHO MONICA) project in Northern Sweden. Odds ratios of stroke with 95% CIs with adjustments for age, gender, smoking, serum cholesterol, diabetes, body mass index, and blood pressure were determined. Anti-PC levels were measured using ELISA. Results— A significant association between low levels of anti-PC at baseline and incident stroke was seen for the whole group of anti-PC levels below the 30th percentile (multivariately adjusted odds ratio, 1.62; CI, 1.11 to 2.35). Analyses of gender-specific associations indicated fairly strong associations for females, especially at the lowest 30th percentile (multivariately adjusted odds ratio, 2.65; CI, 1.41 to 4.95). No associations were noted for men. Conclusion— Low anti-PC is a novel independent risk marker for development of stroke. Measurements of anti-PC could be used to identify immunodeficient subjects at an increased risk for stroke. The possibility that such subjects might be targets for novel modes of treatment such as immunotherapies deserves further investigation. Article in Journal/Newspaper Northern Sweden Ovid Stroke 41 4 607 612 |
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English |
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Background and Purpose— Natural immunoglobulin M antibodies specific for phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown previously that high levels of anti-PC predict a slower progression of atherosclerosis in humans and that low levels of anti-PC are associated with higher risk for cardiovascular disease. Here we determine the association between anti-PC and the incidence of stroke. Methods— Using a nested case control study design, we examined 227 incident cases (125 men and 102 women) of first-time stroke and 455 age- and sex-matched controls identified during a 13-year time period (1985 to 1999) within the population-based cohorts of the Västerbotten Intervention Project (VIP) and the World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease (WHO MONICA) project in Northern Sweden. Odds ratios of stroke with 95% CIs with adjustments for age, gender, smoking, serum cholesterol, diabetes, body mass index, and blood pressure were determined. Anti-PC levels were measured using ELISA. Results— A significant association between low levels of anti-PC at baseline and incident stroke was seen for the whole group of anti-PC levels below the 30th percentile (multivariately adjusted odds ratio, 1.62; CI, 1.11 to 2.35). Analyses of gender-specific associations indicated fairly strong associations for females, especially at the lowest 30th percentile (multivariately adjusted odds ratio, 2.65; CI, 1.41 to 4.95). No associations were noted for men. Conclusion— Low anti-PC is a novel independent risk marker for development of stroke. Measurements of anti-PC could be used to identify immunodeficient subjects at an increased risk for stroke. The possibility that such subjects might be targets for novel modes of treatment such as immunotherapies deserves further investigation. |
format |
Article in Journal/Newspaper |
author |
Fiskesund, Roland Stegmayr, Birgitta Hallmans, Göran Vikström, Max Weinehall, Lars de Faire, Ulf Frostegård, Johan |
spellingShingle |
Fiskesund, Roland Stegmayr, Birgitta Hallmans, Göran Vikström, Max Weinehall, Lars de Faire, Ulf Frostegård, Johan Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden |
author_facet |
Fiskesund, Roland Stegmayr, Birgitta Hallmans, Göran Vikström, Max Weinehall, Lars de Faire, Ulf Frostegård, Johan |
author_sort |
Fiskesund, Roland |
title |
Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden |
title_short |
Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden |
title_full |
Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden |
title_fullStr |
Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden |
title_full_unstemmed |
Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden |
title_sort |
low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern sweden |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2010 |
url |
http://dx.doi.org/10.1161/strokeaha.109.558742 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.109.558742 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Stroke volume 41, issue 4, page 607-612 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/strokeaha.109.558742 |
container_title |
Stroke |
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41 |
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4 |
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607 |
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612 |
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1802648258986639360 |