Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men
Background and Purpose— Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, the relationship between carotid plaque and IMT and cardiovascul...
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Ovid Technologies (Wolters Kluwer Health)
2007
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Online Access: | http://dx.doi.org/10.1161/strokeaha.107.487264 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.107.487264 |
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crovidcr:10.1161/strokeaha.107.487264 2024-06-23T07:57:14+00:00 Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men A 6-Year Follow-Up Study of 6226 Persons: The Tromsø Study Johnsen, Stein Harald Mathiesen, Ellisiv B. Joakimsen, Oddmund Stensland, Eva Wilsgaard, Tom Løchen, Maja-Lisa Njølstad, Inger Arnesen, Egil 2007 http://dx.doi.org/10.1161/strokeaha.107.487264 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.107.487264 en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 38, issue 11, page 2873-2880 ISSN 0039-2499 1524-4628 journal-article 2007 crovidcr https://doi.org/10.1161/strokeaha.107.487264 2024-06-06T04:17:37Z Background and Purpose— Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, the relationship between carotid plaque and IMT and cardiovascular disease has been conflicting. In this prospective, population-based study, we measured carotid IMT, total plaque area, and plaque echogenicity as predictors for first-ever myocardial infarction (MI). Methods— IMT, total plaque area, and plaque echogenicity were measured in 6226 men and women aged 25 to 84 years with no previous MI. The subjects were followed for 6 years and incident MI was registered. Results— During follow-up, MI occurred in 6.6% of men and 3.0% of women. The adjusted relative risk (RR; 95% CI) between the highest plaque area tertile versus no plaque was 1.56 (1.04 to 2.36) in men and 3.95 (2.16 to 7.19) in women. In women, there was a significant trend toward a higher MI risk with more echolucent plaque. The adjusted RR (95% CI) in the highest versus lowest IMT quartile was 1.73 (0.98 to 3.06) in men and 2.86 (1.07 to 7.65) in women. When we excluded bulb IMT from analyses, IMT did not predict MI in either sex. Conclusions— In a general population, carotid plaque area was a stronger predictor of first-ever MI than was IMT. Carotid atherosclerosis was a stronger risk factor for MI in women than in men. In women, the risk of MI increased with plaque echolucency. Article in Journal/Newspaper Tromsø Ovid Tromsø Stroke 38 11 2873 2880 |
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Background and Purpose— Ultrasound of carotid arteries provides measures of intima media thickness (IMT) and plaque, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, the relationship between carotid plaque and IMT and cardiovascular disease has been conflicting. In this prospective, population-based study, we measured carotid IMT, total plaque area, and plaque echogenicity as predictors for first-ever myocardial infarction (MI). Methods— IMT, total plaque area, and plaque echogenicity were measured in 6226 men and women aged 25 to 84 years with no previous MI. The subjects were followed for 6 years and incident MI was registered. Results— During follow-up, MI occurred in 6.6% of men and 3.0% of women. The adjusted relative risk (RR; 95% CI) between the highest plaque area tertile versus no plaque was 1.56 (1.04 to 2.36) in men and 3.95 (2.16 to 7.19) in women. In women, there was a significant trend toward a higher MI risk with more echolucent plaque. The adjusted RR (95% CI) in the highest versus lowest IMT quartile was 1.73 (0.98 to 3.06) in men and 2.86 (1.07 to 7.65) in women. When we excluded bulb IMT from analyses, IMT did not predict MI in either sex. Conclusions— In a general population, carotid plaque area was a stronger predictor of first-ever MI than was IMT. Carotid atherosclerosis was a stronger risk factor for MI in women than in men. In women, the risk of MI increased with plaque echolucency. |
format |
Article in Journal/Newspaper |
author |
Johnsen, Stein Harald Mathiesen, Ellisiv B. Joakimsen, Oddmund Stensland, Eva Wilsgaard, Tom Løchen, Maja-Lisa Njølstad, Inger Arnesen, Egil |
spellingShingle |
Johnsen, Stein Harald Mathiesen, Ellisiv B. Joakimsen, Oddmund Stensland, Eva Wilsgaard, Tom Løchen, Maja-Lisa Njølstad, Inger Arnesen, Egil Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men |
author_facet |
Johnsen, Stein Harald Mathiesen, Ellisiv B. Joakimsen, Oddmund Stensland, Eva Wilsgaard, Tom Løchen, Maja-Lisa Njølstad, Inger Arnesen, Egil |
author_sort |
Johnsen, Stein Harald |
title |
Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men |
title_short |
Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men |
title_full |
Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men |
title_fullStr |
Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men |
title_full_unstemmed |
Carotid Atherosclerosis Is a Stronger Predictor of Myocardial Infarction in Women Than in Men |
title_sort |
carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2007 |
url |
http://dx.doi.org/10.1161/strokeaha.107.487264 https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.107.487264 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Stroke volume 38, issue 11, page 2873-2880 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/strokeaha.107.487264 |
container_title |
Stroke |
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38 |
container_issue |
11 |
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2873 |
op_container_end_page |
2880 |
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1802650781786046464 |