Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016
Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on...
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Ovid Technologies (Wolters Kluwer Health)
2023
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Online Access: | http://dx.doi.org/10.1161/jaha.122.030010 https://www.ahajournals.org/doi/full/10.1161/JAHA.122.030010 |
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crovidcr:10.1161/jaha.122.030010 2023-10-09T21:56:17+02:00 Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 Albrektsen, Grethe Wilsgaard, Tom Heuch, Ivar Løchen, Maja‐Lisa Thelle, Dag Steinar Njølstad, Inger Grimsgaard, Sameline Bønaa, Kaare Harald 2023 http://dx.doi.org/10.1161/jaha.122.030010 https://www.ahajournals.org/doi/full/10.1161/JAHA.122.030010 en eng Ovid Technologies (Wolters Kluwer Health) Journal of the American Heart Association volume 12, issue 14 ISSN 2047-9980 Cardiology and Cardiovascular Medicine journal-article 2023 crovidcr https://doi.org/10.1161/jaha.122.030010 2023-09-22T11:22:03Z Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained from 7 population‐based health surveys in Tromsø, Norway. Diagnoses of MI were obtained from national registers. A linear mixed model was applied to compare age‐ and sex‐specific mean values of total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), and triglyceride concentration by MI status (MI versus non‐MI). Already from young adulthood, 20 to 35 years before the incident MI, individuals with a subsequent incident MI had on average more adverse lipid levels than individuals of the same age and sex without MI. Analogous to a dose–response relationship, there was a clear trend toward more severe adverse lipid levels the lower the age at incident MI ( P <0.001, test for trend through ordered categories <55, 55–74, ≥75 years). This trend was particularly pronounced for high‐density lipoprotein cholesterol in percentage of total cholesterol (both sexes) and for the relative relationship between triglyceride, high‐density lipoprotein cholesterol, and total cholesterol level (women). The difference in mean lipid level by MI status was just as large in women as in men, but the age pattern differed ( P ≤0.05, tests of 3‐way interaction). Conclusions Compared with general population mean levels, adverse lipid levels were seen 20 to 35 years before the incident MI in both men and women. Article in Journal/Newspaper Tromsø Ovid (via Crossref) Norway Tromsø Journal of the American Heart Association 12 14 |
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English |
topic |
Cardiology and Cardiovascular Medicine |
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Cardiology and Cardiovascular Medicine Albrektsen, Grethe Wilsgaard, Tom Heuch, Ivar Løchen, Maja‐Lisa Thelle, Dag Steinar Njølstad, Inger Grimsgaard, Sameline Bønaa, Kaare Harald Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
topic_facet |
Cardiology and Cardiovascular Medicine |
description |
Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained from 7 population‐based health surveys in Tromsø, Norway. Diagnoses of MI were obtained from national registers. A linear mixed model was applied to compare age‐ and sex‐specific mean values of total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), and triglyceride concentration by MI status (MI versus non‐MI). Already from young adulthood, 20 to 35 years before the incident MI, individuals with a subsequent incident MI had on average more adverse lipid levels than individuals of the same age and sex without MI. Analogous to a dose–response relationship, there was a clear trend toward more severe adverse lipid levels the lower the age at incident MI ( P <0.001, test for trend through ordered categories <55, 55–74, ≥75 years). This trend was particularly pronounced for high‐density lipoprotein cholesterol in percentage of total cholesterol (both sexes) and for the relative relationship between triglyceride, high‐density lipoprotein cholesterol, and total cholesterol level (women). The difference in mean lipid level by MI status was just as large in women as in men, but the age pattern differed ( P ≤0.05, tests of 3‐way interaction). Conclusions Compared with general population mean levels, adverse lipid levels were seen 20 to 35 years before the incident MI in both men and women. |
format |
Article in Journal/Newspaper |
author |
Albrektsen, Grethe Wilsgaard, Tom Heuch, Ivar Løchen, Maja‐Lisa Thelle, Dag Steinar Njølstad, Inger Grimsgaard, Sameline Bønaa, Kaare Harald |
author_facet |
Albrektsen, Grethe Wilsgaard, Tom Heuch, Ivar Løchen, Maja‐Lisa Thelle, Dag Steinar Njølstad, Inger Grimsgaard, Sameline Bønaa, Kaare Harald |
author_sort |
Albrektsen, Grethe |
title |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_short |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_full |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_fullStr |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_full_unstemmed |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_sort |
lipid levels during adult lifetime in men and women with and without a subsequent incident myocardial infarction: a longitudinal analysis of data from the tromsø study 1974 to 2016 |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2023 |
url |
http://dx.doi.org/10.1161/jaha.122.030010 https://www.ahajournals.org/doi/full/10.1161/JAHA.122.030010 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Journal of the American Heart Association volume 12, issue 14 ISSN 2047-9980 |
op_doi |
https://doi.org/10.1161/jaha.122.030010 |
container_title |
Journal of the American Heart Association |
container_volume |
12 |
container_issue |
14 |
_version_ |
1779320922412417024 |