Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017
Background Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarker...
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Online Access: | http://dx.doi.org/10.1161/jaha.119.014491 https://www.ahajournals.org/doi/full/10.1161/JAHA.119.014491 |
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crovidcr:10.1161/jaha.119.014491 2024-06-23T07:55:41+00:00 Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 Iakunchykova, Olena Averina, Maria Kudryavtsev, Alexander V. Wilsgaard, Tom Soloviev, Andrey Schirmer, Henrik Cook, Sarah Leon, David A. 2020 http://dx.doi.org/10.1161/jaha.119.014491 https://www.ahajournals.org/doi/full/10.1161/JAHA.119.014491 en eng Ovid Technologies (Wolters Kluwer Health) Journal of the American Heart Association volume 9, issue 1 ISSN 2047-9980 journal-article 2020 crovidcr https://doi.org/10.1161/jaha.119.014491 2024-06-04T06:02:30Z Background Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation. Methods and Results The Know Your Heart study recruited a random sample of 2479 participants from the population of northwest Russia (general population) plus 278 patients (narcology clinic subsample) with alcohol problems. The general population sample was categorized into harmful drinkers, hazardous drinkers, nonproblem drinkers, and nondrinkers, according to self‐reported level of alcohol consumption, whereas the narcology clinic sample was treated as the separate group in the analysis. Measurements were made of the following: (1) high‐sensitivity cardiac troponin T, (2) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and (3) hsCRP (high‐sensitivity C‐reactive protein). The narcology clinic subsample had the most extreme drinking pattern and the highest levels of all 3 biomarkers relative to nonproblem drinkers in the general population: high‐sensitivity cardiac troponin T was elevated by 10.3% (95% CI , 3.7%–17.4%), NT ‐pro BNP by 46.7% (95% CI , 26.8%–69.8%), and hsCRP by 69.2% (95% CI , 43%–100%). In the general population sample, NT ‐pro BNP was 31.5% (95% CI , 3.4%–67.2%) higher among harmful drinkers compared with nonproblem drinkers. Overall, NT ‐pro BNP and hsCRP increased with increasing intensity of alcohol exposure (test of trend P <0.001). Conclusions These results support the hypothesis that heavy alcohol drinking has an adverse effect on cardiac structure and function that may not be driven by atherosclerosis. Article in Journal/Newspaper Northwest Russia Ovid Journal of the American Heart Association 9 1 |
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English |
description |
Background Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation. Methods and Results The Know Your Heart study recruited a random sample of 2479 participants from the population of northwest Russia (general population) plus 278 patients (narcology clinic subsample) with alcohol problems. The general population sample was categorized into harmful drinkers, hazardous drinkers, nonproblem drinkers, and nondrinkers, according to self‐reported level of alcohol consumption, whereas the narcology clinic sample was treated as the separate group in the analysis. Measurements were made of the following: (1) high‐sensitivity cardiac troponin T, (2) NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and (3) hsCRP (high‐sensitivity C‐reactive protein). The narcology clinic subsample had the most extreme drinking pattern and the highest levels of all 3 biomarkers relative to nonproblem drinkers in the general population: high‐sensitivity cardiac troponin T was elevated by 10.3% (95% CI , 3.7%–17.4%), NT ‐pro BNP by 46.7% (95% CI , 26.8%–69.8%), and hsCRP by 69.2% (95% CI , 43%–100%). In the general population sample, NT ‐pro BNP was 31.5% (95% CI , 3.4%–67.2%) higher among harmful drinkers compared with nonproblem drinkers. Overall, NT ‐pro BNP and hsCRP increased with increasing intensity of alcohol exposure (test of trend P <0.001). Conclusions These results support the hypothesis that heavy alcohol drinking has an adverse effect on cardiac structure and function that may not be driven by atherosclerosis. |
format |
Article in Journal/Newspaper |
author |
Iakunchykova, Olena Averina, Maria Kudryavtsev, Alexander V. Wilsgaard, Tom Soloviev, Andrey Schirmer, Henrik Cook, Sarah Leon, David A. |
spellingShingle |
Iakunchykova, Olena Averina, Maria Kudryavtsev, Alexander V. Wilsgaard, Tom Soloviev, Andrey Schirmer, Henrik Cook, Sarah Leon, David A. Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
author_facet |
Iakunchykova, Olena Averina, Maria Kudryavtsev, Alexander V. Wilsgaard, Tom Soloviev, Andrey Schirmer, Henrik Cook, Sarah Leon, David A. |
author_sort |
Iakunchykova, Olena |
title |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_short |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_full |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_fullStr |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_full_unstemmed |
Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A Large Cross‐Sectional Study of Consumption Patterns and Cardiovascular Disease Risk Biomarkers From Northwest Russia, 2015 to 2017 |
title_sort |
evidence for a direct harmful effect of alcohol on myocardial health: a large cross‐sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest russia, 2015 to 2017 |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2020 |
url |
http://dx.doi.org/10.1161/jaha.119.014491 https://www.ahajournals.org/doi/full/10.1161/JAHA.119.014491 |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_source |
Journal of the American Heart Association volume 9, issue 1 ISSN 2047-9980 |
op_doi |
https://doi.org/10.1161/jaha.119.014491 |
container_title |
Journal of the American Heart Association |
container_volume |
9 |
container_issue |
1 |
_version_ |
1802648360458387456 |