Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study
Background Associations of atherosclerosis risk factors with unrecognized myocardial infarction ( UMI ) are unclear. We investigated associations of midlife risk factors with UMI and recognized MI ( RMI ) detected 31 years later by cardiac magnetic resonance. Methods and Results The Reykjavik Study...
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Online Access: | http://dx.doi.org/10.1161/jaha.115.002420 https://www.ahajournals.org/doi/full/10.1161/JAHA.115.002420 |
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crovidcr:10.1161/jaha.115.002420 2024-09-15T18:13:44+00:00 Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study McAreavey, Dorothea Vidal, Jean‐Sébastien Aspelund, Thor Eiriksdottir, Gudny Schelbert, Erik B. Kjartansson, Olafur Cao, Jie J. Thorgeirsson, Gudmundur Sigurdsson, Sigurdur Garcia, Melissa Harris, Tamara B. Launer, Lenore J. Gudnason, Vilmundur Arai, Andrew E. 2016 http://dx.doi.org/10.1161/jaha.115.002420 https://www.ahajournals.org/doi/full/10.1161/JAHA.115.002420 en eng Ovid Technologies (Wolters Kluwer Health) Journal of the American Heart Association volume 5, issue 2 ISSN 2047-9980 journal-article 2016 crovidcr https://doi.org/10.1161/jaha.115.002420 2024-08-30T04:07:41Z Background Associations of atherosclerosis risk factors with unrecognized myocardial infarction ( UMI ) are unclear. We investigated associations of midlife risk factors with UMI and recognized MI ( RMI ) detected 31 years later by cardiac magnetic resonance. Methods and Results The Reykjavik Study (1967–1991) collected serial risk factors in subjects, mean ( SD ) age 48 (7) years. In ICELAND ‐ MI (2004–2007), 936 survivors (76 (5) years) were evaluated by cardiac magnetic resonance. Analysis included logistic regression and random effects modeling. Comparisons are relative to subjects without MI . At baseline midlife evaluation, a modified Framingham risk score was significantly higher in RMI and in UMI versus no MI (7.4 (6.3)%; 7.1 (6.2)% versus 5.4 (5.8)%, P <0.001). RMI and UMI were more frequent in men (65%, 64% versus 43%; P <0.0001). Baseline systolic and diastolic blood pressure were significantly higher in UMI (138 (17) mm Hg versus 133 (17) mm Hg; P <0.006; 87 (10) mm Hg versus 84 (10) mm Hg; P <0.02). Diastolic BP was significantly higher in RMI (88 (10) mm Hg versus 84 (10) mm Hg; P <0.02). Cholesterol and triglycerides were significantly higher in RMI (6.7 (1.1) mmol/L versus 6.2 (1.1) mmol/L; P =0.0005; and 1.4 (0.7) mmol/L versus 1.1 (0.7) mmol/L; P <0.003). Cholesterol trended higher in UMI ( P =0.08). Serial midlife systolic BP was significantly higher in UMI versus no MI (β [ SE ] = 2.69 [1.28] mm Hg, P =0.04). Serial systolic and diastolic BP were significantly higher in RMI versus no MI (4.12 [1.60] mm Hg, P =0.01 and 2.05 [0.91] mm Hg, P =0.03) as were cholesterol (0.43 [0.11] mmol/L, P =0.0001) and triglycerides (0.3 [0.06] mmol/L, P <0.0001). Conclusions Midlife vascular risk factors are associated with UMI and RMI detected by cardiac magnetic resonance 31 years later. Systolic blood pressure was the most significant modifiable risk factor associated with later UMI . Article in Journal/Newspaper Iceland Ovid Journal of the American Heart Association 5 2 |
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English |
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Background Associations of atherosclerosis risk factors with unrecognized myocardial infarction ( UMI ) are unclear. We investigated associations of midlife risk factors with UMI and recognized MI ( RMI ) detected 31 years later by cardiac magnetic resonance. Methods and Results The Reykjavik Study (1967–1991) collected serial risk factors in subjects, mean ( SD ) age 48 (7) years. In ICELAND ‐ MI (2004–2007), 936 survivors (76 (5) years) were evaluated by cardiac magnetic resonance. Analysis included logistic regression and random effects modeling. Comparisons are relative to subjects without MI . At baseline midlife evaluation, a modified Framingham risk score was significantly higher in RMI and in UMI versus no MI (7.4 (6.3)%; 7.1 (6.2)% versus 5.4 (5.8)%, P <0.001). RMI and UMI were more frequent in men (65%, 64% versus 43%; P <0.0001). Baseline systolic and diastolic blood pressure were significantly higher in UMI (138 (17) mm Hg versus 133 (17) mm Hg; P <0.006; 87 (10) mm Hg versus 84 (10) mm Hg; P <0.02). Diastolic BP was significantly higher in RMI (88 (10) mm Hg versus 84 (10) mm Hg; P <0.02). Cholesterol and triglycerides were significantly higher in RMI (6.7 (1.1) mmol/L versus 6.2 (1.1) mmol/L; P =0.0005; and 1.4 (0.7) mmol/L versus 1.1 (0.7) mmol/L; P <0.003). Cholesterol trended higher in UMI ( P =0.08). Serial midlife systolic BP was significantly higher in UMI versus no MI (β [ SE ] = 2.69 [1.28] mm Hg, P =0.04). Serial systolic and diastolic BP were significantly higher in RMI versus no MI (4.12 [1.60] mm Hg, P =0.01 and 2.05 [0.91] mm Hg, P =0.03) as were cholesterol (0.43 [0.11] mmol/L, P =0.0001) and triglycerides (0.3 [0.06] mmol/L, P <0.0001). Conclusions Midlife vascular risk factors are associated with UMI and RMI detected by cardiac magnetic resonance 31 years later. Systolic blood pressure was the most significant modifiable risk factor associated with later UMI . |
format |
Article in Journal/Newspaper |
author |
McAreavey, Dorothea Vidal, Jean‐Sébastien Aspelund, Thor Eiriksdottir, Gudny Schelbert, Erik B. Kjartansson, Olafur Cao, Jie J. Thorgeirsson, Gudmundur Sigurdsson, Sigurdur Garcia, Melissa Harris, Tamara B. Launer, Lenore J. Gudnason, Vilmundur Arai, Andrew E. |
spellingShingle |
McAreavey, Dorothea Vidal, Jean‐Sébastien Aspelund, Thor Eiriksdottir, Gudny Schelbert, Erik B. Kjartansson, Olafur Cao, Jie J. Thorgeirsson, Gudmundur Sigurdsson, Sigurdur Garcia, Melissa Harris, Tamara B. Launer, Lenore J. Gudnason, Vilmundur Arai, Andrew E. Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study |
author_facet |
McAreavey, Dorothea Vidal, Jean‐Sébastien Aspelund, Thor Eiriksdottir, Gudny Schelbert, Erik B. Kjartansson, Olafur Cao, Jie J. Thorgeirsson, Gudmundur Sigurdsson, Sigurdur Garcia, Melissa Harris, Tamara B. Launer, Lenore J. Gudnason, Vilmundur Arai, Andrew E. |
author_sort |
McAreavey, Dorothea |
title |
Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study |
title_short |
Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study |
title_full |
Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study |
title_fullStr |
Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study |
title_full_unstemmed |
Midlife Cardiovascular Risk Factors and Late‐Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND‐MI, the AGES‐Reykjavik Study |
title_sort |
midlife cardiovascular risk factors and late‐life unrecognized and recognized myocardial infarction detect by cardiac magnetic resonance: iceland‐mi, the ages‐reykjavik study |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2016 |
url |
http://dx.doi.org/10.1161/jaha.115.002420 https://www.ahajournals.org/doi/full/10.1161/JAHA.115.002420 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of the American Heart Association volume 5, issue 2 ISSN 2047-9980 |
op_doi |
https://doi.org/10.1161/jaha.115.002420 |
container_title |
Journal of the American Heart Association |
container_volume |
5 |
container_issue |
2 |
_version_ |
1810451491947806720 |