Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy
The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. The study...
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Online Access: | http://dx.doi.org/10.1161/hypertensionaha.120.15702 https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.120.15702 |
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crovidcr:10.1161/hypertensionaha.120.15702 2024-10-13T14:09:43+00:00 Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy A Community-Based Approach Rantakallio, Juhani S.S. Nevalainen, Jaana E. West, Sammeli I. Ollila, Meri-Maija Puukka, Katri Bloigu, Aini H. Järvelin, Marjo-Riitta Tapanainen, Juha S. Franks, Stephen Dunkel, Leo Piltonen, Terhi T. Vääräsmäki, Marja S. Morin-Papunen, Laure C. 2021 http://dx.doi.org/10.1161/hypertensionaha.120.15702 https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.120.15702 en eng Ovid Technologies (Wolters Kluwer Health) Hypertension volume 77, issue 3, page 1010-1019 ISSN 0194-911X 1524-4563 journal-article 2021 crovidcr https://doi.org/10.1161/hypertensionaha.120.15702 2024-09-23T04:20:53Z The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. The study population—NFBC1966 (Northern Finland Birth Cohort 1966)—allowed a long-term follow-up of women from age 14 until 46 years who developed HDP (n=408) or did not (n=3373). HDP diagnosis was confirmed by combining hospital discharge records, data from Finnish Medical Birth Registers, and the questionnaire data at age 46. Women with self-reported PCOS (srPCOS; n=279), defined by both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46, were compared with women without reported PCOS (n=1577). Women with srPCOS had an increased HDP risk (odds ratio, 1.56 [95% CI, 1.03–2.37]), but the association disappeared after adjustment for body mass index. In women with srPCOS and HDP, body mass index increased from age 14 to 46 significantly more than in srPCOS women without HDP (median [interquartile range], 9.82 [6.23–14.6] and 7.21 [4.16–10.5] kg/m 2 , respectively; P <0.001). Also, in non-PCOS women, the increase was higher in women with (7.54 [5.32–11.62] kg/m 2 P <0.001) than without HDP (6.33 [3.90–9.33] kg/m 2 P <0.001). Increase in waist circumference between ages 31 and 46 years was associated with HDP but not with PCOS. Hyperandrogenemia at 31 or 46 years did not associate with HDP (1.44 [0.98–2.11]). In conclusion, obesity, especially abdominal obesity, and weight gain from adolescence to age 46, but not srPCOS or hyperandrogenemia, were associated with an increased risk of HDP. Article in Journal/Newspaper Northern Finland Ovid Hypertension 77 3 1010 1019 |
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The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. The study population—NFBC1966 (Northern Finland Birth Cohort 1966)—allowed a long-term follow-up of women from age 14 until 46 years who developed HDP (n=408) or did not (n=3373). HDP diagnosis was confirmed by combining hospital discharge records, data from Finnish Medical Birth Registers, and the questionnaire data at age 46. Women with self-reported PCOS (srPCOS; n=279), defined by both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46, were compared with women without reported PCOS (n=1577). Women with srPCOS had an increased HDP risk (odds ratio, 1.56 [95% CI, 1.03–2.37]), but the association disappeared after adjustment for body mass index. In women with srPCOS and HDP, body mass index increased from age 14 to 46 significantly more than in srPCOS women without HDP (median [interquartile range], 9.82 [6.23–14.6] and 7.21 [4.16–10.5] kg/m 2 , respectively; P <0.001). Also, in non-PCOS women, the increase was higher in women with (7.54 [5.32–11.62] kg/m 2 P <0.001) than without HDP (6.33 [3.90–9.33] kg/m 2 P <0.001). Increase in waist circumference between ages 31 and 46 years was associated with HDP but not with PCOS. Hyperandrogenemia at 31 or 46 years did not associate with HDP (1.44 [0.98–2.11]). In conclusion, obesity, especially abdominal obesity, and weight gain from adolescence to age 46, but not srPCOS or hyperandrogenemia, were associated with an increased risk of HDP. |
format |
Article in Journal/Newspaper |
author |
Rantakallio, Juhani S.S. Nevalainen, Jaana E. West, Sammeli I. Ollila, Meri-Maija Puukka, Katri Bloigu, Aini H. Järvelin, Marjo-Riitta Tapanainen, Juha S. Franks, Stephen Dunkel, Leo Piltonen, Terhi T. Vääräsmäki, Marja S. Morin-Papunen, Laure C. |
spellingShingle |
Rantakallio, Juhani S.S. Nevalainen, Jaana E. West, Sammeli I. Ollila, Meri-Maija Puukka, Katri Bloigu, Aini H. Järvelin, Marjo-Riitta Tapanainen, Juha S. Franks, Stephen Dunkel, Leo Piltonen, Terhi T. Vääräsmäki, Marja S. Morin-Papunen, Laure C. Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy |
author_facet |
Rantakallio, Juhani S.S. Nevalainen, Jaana E. West, Sammeli I. Ollila, Meri-Maija Puukka, Katri Bloigu, Aini H. Järvelin, Marjo-Riitta Tapanainen, Juha S. Franks, Stephen Dunkel, Leo Piltonen, Terhi T. Vääräsmäki, Marja S. Morin-Papunen, Laure C. |
author_sort |
Rantakallio, Juhani S.S. |
title |
Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy |
title_short |
Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy |
title_full |
Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy |
title_fullStr |
Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy |
title_full_unstemmed |
Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy |
title_sort |
association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1161/hypertensionaha.120.15702 https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.120.15702 |
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Northern Finland |
genre_facet |
Northern Finland |
op_source |
Hypertension volume 77, issue 3, page 1010-1019 ISSN 0194-911X 1524-4563 |
op_doi |
https://doi.org/10.1161/hypertensionaha.120.15702 |
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Hypertension |
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77 |
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3 |
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1010 |
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1019 |
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1812816769445789696 |