Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism
Background— A family history of myocardial infarction (FHMI) has been shown to increase the risk of venous thromboembolism (VTE). The mechanism underlying the association remains unclear. Therefore, we aimed to determine the risks of MI and VTE by FHMI using a cause-specific model and to explore whe...
Published in: | Circulation: Cardiovascular Genetics |
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Online Access: | http://dx.doi.org/10.1161/circgenetics.114.000621 https://www.ahajournals.org/doi/full/10.1161/CIRCGENETICS.114.000621 |
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crovidcr:10.1161/circgenetics.114.000621 2023-05-15T18:34:29+02:00 Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism The Tromsø Study Lind, Caroline Enga, Kristin F. Mathiesen, Ellisiv B. Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne 2014 http://dx.doi.org/10.1161/circgenetics.114.000621 https://www.ahajournals.org/doi/full/10.1161/CIRCGENETICS.114.000621 en eng Ovid Technologies (Wolters Kluwer Health) Circulation: Cardiovascular Genetics volume 7, issue 5, page 684-691 ISSN 1942-325X 1942-3268 Genetics (clinical) Cardiology and Cardiovascular Medicine Genetics journal-article 2014 crovidcr https://doi.org/10.1161/circgenetics.114.000621 2023-01-20T11:09:23Z Background— A family history of myocardial infarction (FHMI) has been shown to increase the risk of venous thromboembolism (VTE). The mechanism underlying the association remains unclear. Therefore, we aimed to determine the risks of MI and VTE by FHMI using a cause-specific model and to explore whether atherosclerotic risk factors could explain the association between FHMI and VTE in a population-based cohort. Methods and Results— The study included 21 624 subjects recruited from the Tromsø Study in 1994 to 1995 and 2001 to 2002. Incident MI and VTE events were registered from date of enrollment to end of follow-up, December 31, 2010. There were 1311 MIs and 428 VTEs during a median follow-up of 15.8 years. FHMI was associated with a 52% increased risk of MI (adjusted hazard ratio, 1.52; 95% confidence interval, 1.35–1.70) and a 26% increased risk of VTE (adjusted hazard ratio, 1.26; 95% confidence interval, 1.02–1.55) in the cause-specific Cox model. Similar results were found using the traditional Cox model. The risk estimates by status of FHMI were highest for unprovoked deep vein thrombosis (adjusted hazard ratio, 1.69; 95% confidence interval, 1.12–2.56), and the risk increased with increasing number of affected relatives. Modifiable atherosclerotic risk factors slightly altered the association between FHMI and MI but had a negligible effect on the association between FHMI and VTE. Conclusions— FHMI was associated with increased risk of both MI and VTE in a cause-specific model. Apparently, the association between FHMI and VTE applied to unprovoked deep vein thrombosis and was not explained by modifiable atherosclerotic risk factors. Article in Journal/Newspaper Tromsø Ovid (via Crossref) Tromsø Circulation: Cardiovascular Genetics 7 5 684 691 |
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Open Polar |
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Ovid (via Crossref) |
op_collection_id |
crovidcr |
language |
English |
topic |
Genetics (clinical) Cardiology and Cardiovascular Medicine Genetics |
spellingShingle |
Genetics (clinical) Cardiology and Cardiovascular Medicine Genetics Lind, Caroline Enga, Kristin F. Mathiesen, Ellisiv B. Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism |
topic_facet |
Genetics (clinical) Cardiology and Cardiovascular Medicine Genetics |
description |
Background— A family history of myocardial infarction (FHMI) has been shown to increase the risk of venous thromboembolism (VTE). The mechanism underlying the association remains unclear. Therefore, we aimed to determine the risks of MI and VTE by FHMI using a cause-specific model and to explore whether atherosclerotic risk factors could explain the association between FHMI and VTE in a population-based cohort. Methods and Results— The study included 21 624 subjects recruited from the Tromsø Study in 1994 to 1995 and 2001 to 2002. Incident MI and VTE events were registered from date of enrollment to end of follow-up, December 31, 2010. There were 1311 MIs and 428 VTEs during a median follow-up of 15.8 years. FHMI was associated with a 52% increased risk of MI (adjusted hazard ratio, 1.52; 95% confidence interval, 1.35–1.70) and a 26% increased risk of VTE (adjusted hazard ratio, 1.26; 95% confidence interval, 1.02–1.55) in the cause-specific Cox model. Similar results were found using the traditional Cox model. The risk estimates by status of FHMI were highest for unprovoked deep vein thrombosis (adjusted hazard ratio, 1.69; 95% confidence interval, 1.12–2.56), and the risk increased with increasing number of affected relatives. Modifiable atherosclerotic risk factors slightly altered the association between FHMI and MI but had a negligible effect on the association between FHMI and VTE. Conclusions— FHMI was associated with increased risk of both MI and VTE in a cause-specific model. Apparently, the association between FHMI and VTE applied to unprovoked deep vein thrombosis and was not explained by modifiable atherosclerotic risk factors. |
format |
Article in Journal/Newspaper |
author |
Lind, Caroline Enga, Kristin F. Mathiesen, Ellisiv B. Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne |
author_facet |
Lind, Caroline Enga, Kristin F. Mathiesen, Ellisiv B. Njølstad, Inger Brækkan, Sigrid K. Hansen, John-Bjarne |
author_sort |
Lind, Caroline |
title |
Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism |
title_short |
Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism |
title_full |
Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism |
title_fullStr |
Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism |
title_full_unstemmed |
Family History of Myocardial Infarction and Cause-Specific Risk of Myocardial Infarction and Venous Thromboembolism |
title_sort |
family history of myocardial infarction and cause-specific risk of myocardial infarction and venous thromboembolism |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2014 |
url |
http://dx.doi.org/10.1161/circgenetics.114.000621 https://www.ahajournals.org/doi/full/10.1161/CIRCGENETICS.114.000621 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Circulation: Cardiovascular Genetics volume 7, issue 5, page 684-691 ISSN 1942-325X 1942-3268 |
op_doi |
https://doi.org/10.1161/circgenetics.114.000621 |
container_title |
Circulation: Cardiovascular Genetics |
container_volume |
7 |
container_issue |
5 |
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684 |
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691 |
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1766219251504381952 |