Abstract 19: Epidemiologic Surveillance of Kawasaki Disease in Manitoba and Northwestern Ontario 2000-2010

• Published in: Circulation
• Main Authors: Pepelassis, Dionysios, Lautatzis, Maria E, Schantz, Daryl, Hyman, Jeff, Soni, Reeni, Buffo, Ilan
• Format: Article in Journal/Newspaper
• Language: English
• Published: Ovid Technologies (Wolters Kluwer Health) 2015
• Subjects: Physiology (medical); Cardiology and Cardiovascular Medicine; Canada; Metis
• Online Access: http://dx.doi.org/10.1161/circ.131.suppl_2.19; http://journals.lww.com/00003017-201504282-00088

Objective: The purpose of this study is to determine the incidence of persistent coronary artery sequelae due to KD between the First Nation/Metis (FN/M) and non First Nation children (n-FN) in the province of Manitoba and Northwestern Ontario, Canada. Methods: This is a 10-year (2000-2010) retrospective chart review study of all patients < 18 years of age identified with KD and persistent coronary artery aneurysms. The data was obtained from the Children’s Hospital of Winnipeg medical records and the Electronic Echocardiography data based at the Variety Heart Centre. Results: A total of 103 children and adolescents with KD and with at least 3 echocardiography studies were enrolled. Complete or incomplete presentation of KD was determined according to the fulfillment for the disease classic criteria on diagnosis. Age at diagnosis ranged between 2 months to 4 years (median 0.5 years) with 2 patients diagnosed during their early infancy (age< 90 days). The median follow up period was 4 years (1.3 to 6.3 years). Persistent coronary artery aneurysms were detected in 10 children (M/F ratio 3:1). Nine (9) of the studied subjects account for the FN/M children group and the remaining 1 is of Asian origin. We observed no n-FN children with permanent cardiac sequelae secondary to KD. Conclusion: There is a significantly higher occurrence of permanent coronary artery lesions due to KD among the FN/M children in the province of Manitoba and Northwestern Ontario. However, this study does not imply direct association of any risk factor, which might be related with our findings. Socio-environmental or even genetic factors might contribute to these findings. Nevertheless, these speculations are beyond the scope of this study. We suggest that a strategy of early, diagnosis and treatment of KD based on the latest AHA guidelines, when we deal with patients of these ethnic/racial groups, should be implemented.