Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation
Introduction: Intra-arrest cooling has been shown to improve survival and neurologic outcome in animal models. The aim of this study was to assess the effect of Sodium Nitroprusside enhanced Cardiopulmonary Resuscitation (SNPeCPR) on heat exchange during surface cooling. We hypothesized that SNPeCPR...
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Ovid Technologies (Wolters Kluwer Health)
2014
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Online Access: | http://dx.doi.org/10.1161/circ.130.suppl_2.2 http://journals.lww.com/00003017-201411251-00002 |
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crovidcr:10.1161/circ.130.suppl_2.2 2023-05-15T15:18:40+02:00 Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation Debaty, Guillaume Matsuura, Timothy Bartos, Jason Rees, Jennifer McKnite, Scott Lurie, Keith Yannopoulos, Demetris 2014 http://dx.doi.org/10.1161/circ.130.suppl_2.2 http://journals.lww.com/00003017-201411251-00002 en eng Ovid Technologies (Wolters Kluwer Health) Circulation volume 130, issue suppl_2 ISSN 0009-7322 1524-4539 Physiology (medical) Cardiology and Cardiovascular Medicine journal-article 2014 crovidcr https://doi.org/10.1161/circ.130.suppl_2.2 2022-05-29T06:42:27Z Introduction: Intra-arrest cooling has been shown to improve survival and neurologic outcome in animal models. The aim of this study was to assess the effect of Sodium Nitroprusside enhanced Cardiopulmonary Resuscitation (SNPeCPR) on heat exchange during surface cooling. We hypothesized that SNPeCPR would decrease the time to reach brain temperature to <35°C compared to Active Compression Decompression plus Impedance Threshold Device (ACD+ITD) CPR alone, when surface cooling starts during CPR. Further, addition of epinephrine during SNPeCPR would mitigate heat exchange. Methods: After 10 minutes of untreated ventricular fibrillation, 26 animals were randomized to 3 different protocols: SNPeCPR (n=6), SNPeCPR plus epinephrine (SNP+EPI, n=10) and ACD+ITD alone (Control, n=10). All animals received surface cooling with ice bags at the initiation of CPR. SNPeCPR included ACD+ITD plus abdominal binding, 2mg of SNP every 4min, and no epinephrine during CPR. Control and SNP+EPI groups included 0.5mg of epinephrine every 4min during CPR. Defibrillation occurred after 10 minutes of CPR. After ROSC, an Arctic Sun® at maximum cooling was used on all animals. The primary endpoint was the time to reach brain temperature <35°C. Hemodynamic parameters were recorded continuously. Data are presented as mean ± SEM. ANOVA or Kruskal Wallis test were used to compare continuous variables. Results: Time to reach brain temperature of 35°C was decreased with SNPeCPR vs. Control or SNP+EPI (18 ± 6 min, 53 ± 8 min and 40 ± 9 min, respectively, p=0.03). All animals survived 2h in the SNPeCPR group and 9/10 in the two other groups. Carotid blood flow was higher during CPR in the SNPeCPR group (96 ± 16 ml/min versus 26 ± 7 and 35 ± 5 in the Control and SNP+EPI group, respectively p=0.04). There were no other differences in hemodynamic parameters. Conclusion: This study demonstrates that SNPeCPR facilitates intra-CPR hypothermia, with the brain reaching target temperature (35°C) in less than half of the time of controls without ... Article in Journal/Newspaper Arctic Ovid (via Crossref) Arctic Circulation 130 suppl_2 |
institution |
Open Polar |
collection |
Ovid (via Crossref) |
op_collection_id |
crovidcr |
language |
English |
topic |
Physiology (medical) Cardiology and Cardiovascular Medicine |
spellingShingle |
Physiology (medical) Cardiology and Cardiovascular Medicine Debaty, Guillaume Matsuura, Timothy Bartos, Jason Rees, Jennifer McKnite, Scott Lurie, Keith Yannopoulos, Demetris Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation |
topic_facet |
Physiology (medical) Cardiology and Cardiovascular Medicine |
description |
Introduction: Intra-arrest cooling has been shown to improve survival and neurologic outcome in animal models. The aim of this study was to assess the effect of Sodium Nitroprusside enhanced Cardiopulmonary Resuscitation (SNPeCPR) on heat exchange during surface cooling. We hypothesized that SNPeCPR would decrease the time to reach brain temperature to <35°C compared to Active Compression Decompression plus Impedance Threshold Device (ACD+ITD) CPR alone, when surface cooling starts during CPR. Further, addition of epinephrine during SNPeCPR would mitigate heat exchange. Methods: After 10 minutes of untreated ventricular fibrillation, 26 animals were randomized to 3 different protocols: SNPeCPR (n=6), SNPeCPR plus epinephrine (SNP+EPI, n=10) and ACD+ITD alone (Control, n=10). All animals received surface cooling with ice bags at the initiation of CPR. SNPeCPR included ACD+ITD plus abdominal binding, 2mg of SNP every 4min, and no epinephrine during CPR. Control and SNP+EPI groups included 0.5mg of epinephrine every 4min during CPR. Defibrillation occurred after 10 minutes of CPR. After ROSC, an Arctic Sun® at maximum cooling was used on all animals. The primary endpoint was the time to reach brain temperature <35°C. Hemodynamic parameters were recorded continuously. Data are presented as mean ± SEM. ANOVA or Kruskal Wallis test were used to compare continuous variables. Results: Time to reach brain temperature of 35°C was decreased with SNPeCPR vs. Control or SNP+EPI (18 ± 6 min, 53 ± 8 min and 40 ± 9 min, respectively, p=0.03). All animals survived 2h in the SNPeCPR group and 9/10 in the two other groups. Carotid blood flow was higher during CPR in the SNPeCPR group (96 ± 16 ml/min versus 26 ± 7 and 35 ± 5 in the Control and SNP+EPI group, respectively p=0.04). There were no other differences in hemodynamic parameters. Conclusion: This study demonstrates that SNPeCPR facilitates intra-CPR hypothermia, with the brain reaching target temperature (35°C) in less than half of the time of controls without ... |
format |
Article in Journal/Newspaper |
author |
Debaty, Guillaume Matsuura, Timothy Bartos, Jason Rees, Jennifer McKnite, Scott Lurie, Keith Yannopoulos, Demetris |
author_facet |
Debaty, Guillaume Matsuura, Timothy Bartos, Jason Rees, Jennifer McKnite, Scott Lurie, Keith Yannopoulos, Demetris |
author_sort |
Debaty, Guillaume |
title |
Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation |
title_short |
Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation |
title_full |
Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation |
title_fullStr |
Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation |
title_full_unstemmed |
Abstract 2: Sodium Nitroprusside--Enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Cerebral Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation |
title_sort |
abstract 2: sodium nitroprusside--enhanced cardiopulmonary resuscitation facilitates intra-arrest cerebral therapeutic hypothermia in a porcine model of prolonged ventricular fibrillation |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2014 |
url |
http://dx.doi.org/10.1161/circ.130.suppl_2.2 http://journals.lww.com/00003017-201411251-00002 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Circulation volume 130, issue suppl_2 ISSN 0009-7322 1524-4539 |
op_doi |
https://doi.org/10.1161/circ.130.suppl_2.2 |
container_title |
Circulation |
container_volume |
130 |
container_issue |
suppl_2 |
_version_ |
1766348852300873728 |