Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions
Background and Purpose —An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. Me...
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Ovid Technologies (Wolters Kluwer Health)
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crovidcr:10.1161/01.str.30.10.2013 2024-10-06T13:51:37+00:00 Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions Results From a Nested Case-Control Study in Northern Sweden Glader, Christine Ahlbeck Stegmayr, Birgitta Boman, Jens Stenlund, Hans Weinehall, Lars Hallmans, Göran Dahlén, Gösta H. 1999 http://dx.doi.org/10.1161/01.str.30.10.2013 https://www.ahajournals.org/doi/full/10.1161/01.STR.30.10.2013 en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 30, issue 10, page 2013-2018 ISSN 0039-2499 1524-4628 journal-article 1999 crovidcr https://doi.org/10.1161/01.str.30.10.2013 2024-09-09T05:59:04Z Background and Purpose —An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. Methods —This incident case-control study included 101 case subjects (cases) who had suffered ischemic cerebral infarctions and 201 matched control subjects (controls). The study population was nested within the Västerbotten Intervention Program or the WHO MONICA project. Plasma samples were measured for C pneumoniae –specific IgG and IgA antibodies and Lp(a). Results —A significantly higher mean Lp(a) level was found in female cases than in female controls. However, plasma Lp(a) was unable to predict ischemic cerebral infarctions in either women or men. The proportion of individuals with positive C pneumoniae –specific IgG or IgA titers did not differ between cases and controls. Antibody titers were unable to predict a future stroke. The proportion of individuals with a positive C pneumoniae IgG titer in combination with a high Lp(a) level did not differ significantly between cases and controls. Conclusions —These data suggest that there is no association between baseline plasma Lp(a) levels, presence of C pneumoniae antibodies, and future ischemic cerebral infarctions. Furthermore, no evidence of an interactive effect between high Lp(a) levels and C pneumoniae IgG titers was found. However, selection bias and a recent C pneumoniae epidemic may have influenced the results. Article in Journal/Newspaper Northern Sweden Ovid Stroke 30 10 2013 2018 |
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English |
description |
Background and Purpose —An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. Methods —This incident case-control study included 101 case subjects (cases) who had suffered ischemic cerebral infarctions and 201 matched control subjects (controls). The study population was nested within the Västerbotten Intervention Program or the WHO MONICA project. Plasma samples were measured for C pneumoniae –specific IgG and IgA antibodies and Lp(a). Results —A significantly higher mean Lp(a) level was found in female cases than in female controls. However, plasma Lp(a) was unable to predict ischemic cerebral infarctions in either women or men. The proportion of individuals with positive C pneumoniae –specific IgG or IgA titers did not differ between cases and controls. Antibody titers were unable to predict a future stroke. The proportion of individuals with a positive C pneumoniae IgG titer in combination with a high Lp(a) level did not differ significantly between cases and controls. Conclusions —These data suggest that there is no association between baseline plasma Lp(a) levels, presence of C pneumoniae antibodies, and future ischemic cerebral infarctions. Furthermore, no evidence of an interactive effect between high Lp(a) levels and C pneumoniae IgG titers was found. However, selection bias and a recent C pneumoniae epidemic may have influenced the results. |
format |
Article in Journal/Newspaper |
author |
Glader, Christine Ahlbeck Stegmayr, Birgitta Boman, Jens Stenlund, Hans Weinehall, Lars Hallmans, Göran Dahlén, Gösta H. |
spellingShingle |
Glader, Christine Ahlbeck Stegmayr, Birgitta Boman, Jens Stenlund, Hans Weinehall, Lars Hallmans, Göran Dahlén, Gösta H. Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions |
author_facet |
Glader, Christine Ahlbeck Stegmayr, Birgitta Boman, Jens Stenlund, Hans Weinehall, Lars Hallmans, Göran Dahlén, Gösta H. |
author_sort |
Glader, Christine Ahlbeck |
title |
Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions |
title_short |
Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions |
title_full |
Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions |
title_fullStr |
Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions |
title_full_unstemmed |
Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions |
title_sort |
chlamydia pneumoniae antibodies and high lipoprotein(a) levels do not predict ischemic cerebral infarctions |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
1999 |
url |
http://dx.doi.org/10.1161/01.str.30.10.2013 https://www.ahajournals.org/doi/full/10.1161/01.STR.30.10.2013 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Stroke volume 30, issue 10, page 2013-2018 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/01.str.30.10.2013 |
container_title |
Stroke |
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30 |
container_issue |
10 |
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2013 |
op_container_end_page |
2018 |
_version_ |
1812179832968052736 |