Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden
Background and Purpose— Taking advantage of low genetic variations in northern Sweden, we performed a genome-wide linkage scan to investigate the susceptibility loci for common forms of stroke. Methods— Fifty-six families, containing multiple cases of stroke and whose data had been previously used t...
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Ovid Technologies (Wolters Kluwer Health)
2007
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Online Access: | http://dx.doi.org/10.1161/01.str.0000251643.37454.16 https://www.ahajournals.org/doi/full/10.1161/01.STR.0000251643.37454.16 |
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crovidcr:10.1161/01.str.0000251643.37454.16 2024-04-28T08:32:34+00:00 Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden Nilsson-Ardnor, Sofie Janunger, Tomas Wiklund, Per-Gunnar Lackovic, Kurt Nilsson, Anna Karin Lindgren, Petter Escher, Stefan A. Stegmayr, Birgitta Asplund, Kjell Holmberg, Dan 2007 http://dx.doi.org/10.1161/01.str.0000251643.37454.16 https://www.ahajournals.org/doi/full/10.1161/01.STR.0000251643.37454.16 en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 38, issue 1, page 34-40 ISSN 0039-2499 1524-4628 Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) journal-article 2007 crovidcr https://doi.org/10.1161/01.str.0000251643.37454.16 2024-04-02T07:59:06Z Background and Purpose— Taking advantage of low genetic variations in northern Sweden, we performed a genome-wide linkage scan to investigate the susceptibility loci for common forms of stroke. Methods— Fifty-six families, containing multiple cases of stroke and whose data had been previously used to replicate linkage to the phosphodiesterase 4D locus on chromosome 5q, were genotyped in a genome-wide scan. Fine mapping was performed, and subsequently 53 additional families from the same region were genotyped over the candidate regions. Results— Linkage calculations were performed by using 3 different disease models, from a very broad (all stroke cases defined by World Health Organization MONICA criteria) to a narrower (ischemic stroke only) stroke phenotype. With all models, nonparametric multipoint linkage analysis yielded allele-sharing log of the odds (LOD) scores >1.2 at 9 locations: 1p34, 5q13, 7q35, 9q22, 9q34, 13q32, 14q32, 18p11, and 20q13. The highest allele-sharing LOD scores were obtained on chromosomes 5q (previously reported), 1p (LOD=2.09), and 18p (LOD=2.14). Fine mapping resulted in increased allele-sharing LOD scores for chromosome 5q (previously reported) and 9q22 (LOD=1.56), but all others decreased. Combining these initial results with a subsequent analysis of 53 additional families, we obtained the highest allele-sharing LOD scores on chromosomes 5q, 13q, and 18p, although none reached the initial genome-wide allele-sharing LOD scores. Conclusions— Genetic analysis of stroke in families from northern Sweden did not identify any new major stroke loci. This indicates that multiple minor susceptibility loci in addition to the previously known locus on chromosome 5 could contribute to the disease. Article in Journal/Newspaper Northern Sweden Ovid Stroke 38 1 34 40 |
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English |
topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
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Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) Nilsson-Ardnor, Sofie Janunger, Tomas Wiklund, Per-Gunnar Lackovic, Kurt Nilsson, Anna Karin Lindgren, Petter Escher, Stefan A. Stegmayr, Birgitta Asplund, Kjell Holmberg, Dan Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden |
topic_facet |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
description |
Background and Purpose— Taking advantage of low genetic variations in northern Sweden, we performed a genome-wide linkage scan to investigate the susceptibility loci for common forms of stroke. Methods— Fifty-six families, containing multiple cases of stroke and whose data had been previously used to replicate linkage to the phosphodiesterase 4D locus on chromosome 5q, were genotyped in a genome-wide scan. Fine mapping was performed, and subsequently 53 additional families from the same region were genotyped over the candidate regions. Results— Linkage calculations were performed by using 3 different disease models, from a very broad (all stroke cases defined by World Health Organization MONICA criteria) to a narrower (ischemic stroke only) stroke phenotype. With all models, nonparametric multipoint linkage analysis yielded allele-sharing log of the odds (LOD) scores >1.2 at 9 locations: 1p34, 5q13, 7q35, 9q22, 9q34, 13q32, 14q32, 18p11, and 20q13. The highest allele-sharing LOD scores were obtained on chromosomes 5q (previously reported), 1p (LOD=2.09), and 18p (LOD=2.14). Fine mapping resulted in increased allele-sharing LOD scores for chromosome 5q (previously reported) and 9q22 (LOD=1.56), but all others decreased. Combining these initial results with a subsequent analysis of 53 additional families, we obtained the highest allele-sharing LOD scores on chromosomes 5q, 13q, and 18p, although none reached the initial genome-wide allele-sharing LOD scores. Conclusions— Genetic analysis of stroke in families from northern Sweden did not identify any new major stroke loci. This indicates that multiple minor susceptibility loci in addition to the previously known locus on chromosome 5 could contribute to the disease. |
format |
Article in Journal/Newspaper |
author |
Nilsson-Ardnor, Sofie Janunger, Tomas Wiklund, Per-Gunnar Lackovic, Kurt Nilsson, Anna Karin Lindgren, Petter Escher, Stefan A. Stegmayr, Birgitta Asplund, Kjell Holmberg, Dan |
author_facet |
Nilsson-Ardnor, Sofie Janunger, Tomas Wiklund, Per-Gunnar Lackovic, Kurt Nilsson, Anna Karin Lindgren, Petter Escher, Stefan A. Stegmayr, Birgitta Asplund, Kjell Holmberg, Dan |
author_sort |
Nilsson-Ardnor, Sofie |
title |
Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden |
title_short |
Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden |
title_full |
Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden |
title_fullStr |
Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden |
title_full_unstemmed |
Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden |
title_sort |
genome-wide linkage scan of common stroke in families from northern sweden |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2007 |
url |
http://dx.doi.org/10.1161/01.str.0000251643.37454.16 https://www.ahajournals.org/doi/full/10.1161/01.STR.0000251643.37454.16 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Stroke volume 38, issue 1, page 34-40 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/01.str.0000251643.37454.16 |
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Stroke |
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38 |
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1 |
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34 |
op_container_end_page |
40 |
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1797589712403169280 |