Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke
Background and Purpose— Folate metabolism has been implicated in stroke. However, the possibility of a role for folate and vitamin B 12 , independent of their effects on homocysteine status, remains to be explored. The aim of this prospective, nested case-referent study was to relate plasma and diet...
Published in: | Stroke |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Ovid Technologies (Wolters Kluwer Health)
2005
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1161/01.str.0000169934.96354.3a https://www.ahajournals.org/doi/full/10.1161/01.STR.0000169934.96354.3a |
id |
crovidcr:10.1161/01.str.0000169934.96354.3a |
---|---|
record_format |
openpolar |
spelling |
crovidcr:10.1161/01.str.0000169934.96354.3a 2024-10-06T13:51:37+00:00 Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke A Prospective, Nested Case-Referent Study of Plasma Concentrations and Dietary Intake Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Stegmayr, Birgitta Hallmans, Göran K. Nilsson, Torbjörn Weinehall, Lars Witthöft, Cornelia Palmqvist, Richard Winkvist, Anna 2005 http://dx.doi.org/10.1161/01.str.0000169934.96354.3a https://www.ahajournals.org/doi/full/10.1161/01.STR.0000169934.96354.3a en eng Ovid Technologies (Wolters Kluwer Health) Stroke volume 36, issue 7, page 1426-1431 ISSN 0039-2499 1524-4628 journal-article 2005 crovidcr https://doi.org/10.1161/01.str.0000169934.96354.3a 2024-09-12T05:00:00Z Background and Purpose— Folate metabolism has been implicated in stroke. However, the possibility of a role for folate and vitamin B 12 , independent of their effects on homocysteine status, remains to be explored. The aim of this prospective, nested case-referent study was to relate plasma and dietary intake levels of folate and vitamin B 12 to risk of stroke, taking into consideration plasma homocysteine concentrations and methylenetetrahydrofolate reductase polymorphisms. Methods— Subjects were 334 ischemic and 62 hemorrhagic stroke cases and matched double referents from the population-based Northern Sweden Health and Disease Cohort. Results— Plasma folate was statistically significantly associated with risk of hemorrhagic stroke in an inverse linear manner, both in univariate analysis and after adjustment for conventional risk factors including hypertension (odds ratio [OR] for highest versus lowest quartile 0.21 (95% confidence interval [CI], 0.06 to 0.71; P for trend=0.008)). Risk estimates were attenuated by inclusion of homocysteine in the model (OR, 0.34; 95% CI, 0.08 to 1.40; P for trend=0.088). A similar pattern was observed for increasing folate intake (multivariate OR, 0.07; 95% CI, 0.01 to 0.55; P for trend=0.031 without homocysteine, and OR, 0.16, 95% CI, 0.02 to 1.23; P for trend=0.118 with homocysteine in the analysis). We found little evidence of an association between plasma or dietary folate and risk of ischemic stroke. Neither plasma nor dietary vitamin B 12 was associated with risk of either stroke subtype. Conclusions— The results of this study suggest a protective role for folate, possibly in addition to its effects on homocysteine status, in hemorrhagic but not ischemic stroke. Article in Journal/Newspaper Northern Sweden Ovid Stroke 36 7 1426 1431 |
institution |
Open Polar |
collection |
Ovid |
op_collection_id |
crovidcr |
language |
English |
description |
Background and Purpose— Folate metabolism has been implicated in stroke. However, the possibility of a role for folate and vitamin B 12 , independent of their effects on homocysteine status, remains to be explored. The aim of this prospective, nested case-referent study was to relate plasma and dietary intake levels of folate and vitamin B 12 to risk of stroke, taking into consideration plasma homocysteine concentrations and methylenetetrahydrofolate reductase polymorphisms. Methods— Subjects were 334 ischemic and 62 hemorrhagic stroke cases and matched double referents from the population-based Northern Sweden Health and Disease Cohort. Results— Plasma folate was statistically significantly associated with risk of hemorrhagic stroke in an inverse linear manner, both in univariate analysis and after adjustment for conventional risk factors including hypertension (odds ratio [OR] for highest versus lowest quartile 0.21 (95% confidence interval [CI], 0.06 to 0.71; P for trend=0.008)). Risk estimates were attenuated by inclusion of homocysteine in the model (OR, 0.34; 95% CI, 0.08 to 1.40; P for trend=0.088). A similar pattern was observed for increasing folate intake (multivariate OR, 0.07; 95% CI, 0.01 to 0.55; P for trend=0.031 without homocysteine, and OR, 0.16, 95% CI, 0.02 to 1.23; P for trend=0.118 with homocysteine in the analysis). We found little evidence of an association between plasma or dietary folate and risk of ischemic stroke. Neither plasma nor dietary vitamin B 12 was associated with risk of either stroke subtype. Conclusions— The results of this study suggest a protective role for folate, possibly in addition to its effects on homocysteine status, in hemorrhagic but not ischemic stroke. |
format |
Article in Journal/Newspaper |
author |
Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Stegmayr, Birgitta Hallmans, Göran K. Nilsson, Torbjörn Weinehall, Lars Witthöft, Cornelia Palmqvist, Richard Winkvist, Anna |
spellingShingle |
Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Stegmayr, Birgitta Hallmans, Göran K. Nilsson, Torbjörn Weinehall, Lars Witthöft, Cornelia Palmqvist, Richard Winkvist, Anna Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke |
author_facet |
Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Stegmayr, Birgitta Hallmans, Göran K. Nilsson, Torbjörn Weinehall, Lars Witthöft, Cornelia Palmqvist, Richard Winkvist, Anna |
author_sort |
Van Guelpen, Bethany |
title |
Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke |
title_short |
Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke |
title_full |
Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke |
title_fullStr |
Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke |
title_full_unstemmed |
Folate, Vitamin B 12 , and Risk of Ischemic and Hemorrhagic Stroke |
title_sort |
folate, vitamin b 12 , and risk of ischemic and hemorrhagic stroke |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2005 |
url |
http://dx.doi.org/10.1161/01.str.0000169934.96354.3a https://www.ahajournals.org/doi/full/10.1161/01.STR.0000169934.96354.3a |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Stroke volume 36, issue 7, page 1426-1431 ISSN 0039-2499 1524-4628 |
op_doi |
https://doi.org/10.1161/01.str.0000169934.96354.3a |
container_title |
Stroke |
container_volume |
36 |
container_issue |
7 |
container_start_page |
1426 |
op_container_end_page |
1431 |
_version_ |
1812179843559718912 |