Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction
Background Few epidemiological studies have investigated the relative importance of major coronary risk factors in the two sexes within the same study population. In particular, it is not clear whether smoking carries a similar risk of coronary heart disease in men and women. Methods and Results The...
Published in: | Circulation |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Ovid Technologies (Wolters Kluwer Health)
1996
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1161/01.cir.93.3.450 https://www.ahajournals.org/doi/full/10.1161/01.CIR.93.3.450 |
id |
crovidcr:10.1161/01.cir.93.3.450 |
---|---|
record_format |
openpolar |
spelling |
crovidcr:10.1161/01.cir.93.3.450 2024-09-30T14:34:54+00:00 Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction A 12-Year Follow-up of the Finnmark Study Njølstad, Inger Arnesen, Egil Lund-Larsen, Per G. 1996 http://dx.doi.org/10.1161/01.cir.93.3.450 https://www.ahajournals.org/doi/full/10.1161/01.CIR.93.3.450 en eng Ovid Technologies (Wolters Kluwer Health) Circulation volume 93, issue 3, page 450-456 ISSN 0009-7322 1524-4539 journal-article 1996 crovidcr https://doi.org/10.1161/01.cir.93.3.450 2024-09-17T04:25:13Z Background Few epidemiological studies have investigated the relative importance of major coronary risk factors in the two sexes within the same study population. In particular, it is not clear whether smoking carries a similar risk of coronary heart disease in men and women. Methods and Results The associations between smoking, serum lipids, blood pressure, and myocardial infarction were examined in a population-based prospective study of 11 843 men and women aged 35 to 52 years at entry. During 12 years, 495 cases of first myocardial infarction among men and 103 cases among women were identified. Myocardial infarction incidence was 4.6 times higher among men. The incidence was increased sixfold in women and threefold in men who smoked at least 20 cigarettes per day compared with never-smokers, and the rate in female heavy smokers exceeded that of never-smoking men. Multivariate analysis identified current smoking as a stronger risk factor in women (relative risk, 3.3; 95% confidence interval [CI], 2.1 to 5.1) than in men (relative risk, 1.9; 95% CI, 1.6 to 2.3). Among those under 45 years old at entry, the smoking-related sex difference was more pronounced (in women: relative risk, 7.1; 95% CI, 2.6 to 19.1) (in men: relative risk, 2.3; 95% CI, 1.6 to 3.2). Serum total cholesterol, HDL cholesterol, and systolic blood pressure were also highly significant predictors in both sexes. Conclusions Smoking was a stronger risk factor for myocardial infarction in middle-aged women than in men. Relative risks associated with serum lipids and blood pressure were similar despite large sex differences in myocardial infarction incidence rates. Article in Journal/Newspaper Finnmark Finnmark Ovid Circulation 93 3 450 456 |
institution |
Open Polar |
collection |
Ovid |
op_collection_id |
crovidcr |
language |
English |
description |
Background Few epidemiological studies have investigated the relative importance of major coronary risk factors in the two sexes within the same study population. In particular, it is not clear whether smoking carries a similar risk of coronary heart disease in men and women. Methods and Results The associations between smoking, serum lipids, blood pressure, and myocardial infarction were examined in a population-based prospective study of 11 843 men and women aged 35 to 52 years at entry. During 12 years, 495 cases of first myocardial infarction among men and 103 cases among women were identified. Myocardial infarction incidence was 4.6 times higher among men. The incidence was increased sixfold in women and threefold in men who smoked at least 20 cigarettes per day compared with never-smokers, and the rate in female heavy smokers exceeded that of never-smoking men. Multivariate analysis identified current smoking as a stronger risk factor in women (relative risk, 3.3; 95% confidence interval [CI], 2.1 to 5.1) than in men (relative risk, 1.9; 95% CI, 1.6 to 2.3). Among those under 45 years old at entry, the smoking-related sex difference was more pronounced (in women: relative risk, 7.1; 95% CI, 2.6 to 19.1) (in men: relative risk, 2.3; 95% CI, 1.6 to 3.2). Serum total cholesterol, HDL cholesterol, and systolic blood pressure were also highly significant predictors in both sexes. Conclusions Smoking was a stronger risk factor for myocardial infarction in middle-aged women than in men. Relative risks associated with serum lipids and blood pressure were similar despite large sex differences in myocardial infarction incidence rates. |
format |
Article in Journal/Newspaper |
author |
Njølstad, Inger Arnesen, Egil Lund-Larsen, Per G. |
spellingShingle |
Njølstad, Inger Arnesen, Egil Lund-Larsen, Per G. Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction |
author_facet |
Njølstad, Inger Arnesen, Egil Lund-Larsen, Per G. |
author_sort |
Njølstad, Inger |
title |
Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction |
title_short |
Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction |
title_full |
Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction |
title_fullStr |
Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction |
title_full_unstemmed |
Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction |
title_sort |
smoking, serum lipids, blood pressure, and sex differences in myocardial infarction |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
1996 |
url |
http://dx.doi.org/10.1161/01.cir.93.3.450 https://www.ahajournals.org/doi/full/10.1161/01.CIR.93.3.450 |
genre |
Finnmark Finnmark |
genre_facet |
Finnmark Finnmark |
op_source |
Circulation volume 93, issue 3, page 450-456 ISSN 0009-7322 1524-4539 |
op_doi |
https://doi.org/10.1161/01.cir.93.3.450 |
container_title |
Circulation |
container_volume |
93 |
container_issue |
3 |
container_start_page |
450 |
op_container_end_page |
456 |
_version_ |
1811638353646321664 |