Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation.
Coronary arteriosclerosis was examined in cultured Atlantic salmon (Salmo salar L.) maintained on normal and cholesterol-enriched diets in both freshwater and saltwater during the period when they normally mature (June to December). The incidence of lesions was high (48% or greater) in all experimen...
Published in: | Arteriosclerosis: An Official Journal of the American Heart Association, Inc. |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Ovid Technologies (Wolters Kluwer Health)
1986
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Online Access: | http://dx.doi.org/10.1161/01.atv.6.4.453 https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.6.4.453 |
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crovidcr:10.1161/01.atv.6.4.453 2024-01-14T10:05:28+01:00 Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. Farrell, A P Saunders, R L Freeman, H C Mommsen, T P 1986 http://dx.doi.org/10.1161/01.atv.6.4.453 https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.6.4.453 en eng Ovid Technologies (Wolters Kluwer Health) Arteriosclerosis: An Official Journal of the American Heart Association, Inc. volume 6, issue 4, page 453-461 ISSN 0276-5047 Cardiology and Cardiovascular Medicine journal-article 1986 crovidcr https://doi.org/10.1161/01.atv.6.4.453 2023-12-15T10:08:34Z Coronary arteriosclerosis was examined in cultured Atlantic salmon (Salmo salar L.) maintained on normal and cholesterol-enriched diets in both freshwater and saltwater during the period when they normally mature (June to December). The incidence of lesions was high (48% or greater) in all experimental subgroups (assigned according to diet, salinity, sex, and maturation status). The primary factor in the development of arteriosclerotic lesions was not established, but the high frequency of lesions in immature fish suggests that it was not maturation. However, maturation was associated with a significant increase in the incidence of lesions and was, therefore, an important secondary factor in the etiology of the disease. Furthermore, diet had a secondary influence on the development of lesions since the cholesterol supplement was also associated with an increase in the incidence of lesions. The cholesterol supplement significantly increased the total plasma cholesterol level in all subgroups; the low density lipoprotein fraction (total cholesterol minus the high density lipoprotein fraction) was also elevated in seven of eight paired subgroups. Plasma free fatty acids and triglycerides were unaffected by the cholesterol supplement. The elevated total cholesterol and low density lipoprotein levels resulting from the cholesterol-enriched diet and the associated increase in the incidence of lesions was most prominent in mature males and females held in freshwater. Salinity had no demonstrable effect on lesion incidence, but the severity of lesions tended to be greater in freshwater fish. Article in Journal/Newspaper Atlantic salmon Salmo salar Ovid (via Crossref) Arteriosclerosis: An Official Journal of the American Heart Association, Inc. 6 4 453 461 |
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Ovid (via Crossref) |
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language |
English |
topic |
Cardiology and Cardiovascular Medicine |
spellingShingle |
Cardiology and Cardiovascular Medicine Farrell, A P Saunders, R L Freeman, H C Mommsen, T P Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. |
topic_facet |
Cardiology and Cardiovascular Medicine |
description |
Coronary arteriosclerosis was examined in cultured Atlantic salmon (Salmo salar L.) maintained on normal and cholesterol-enriched diets in both freshwater and saltwater during the period when they normally mature (June to December). The incidence of lesions was high (48% or greater) in all experimental subgroups (assigned according to diet, salinity, sex, and maturation status). The primary factor in the development of arteriosclerotic lesions was not established, but the high frequency of lesions in immature fish suggests that it was not maturation. However, maturation was associated with a significant increase in the incidence of lesions and was, therefore, an important secondary factor in the etiology of the disease. Furthermore, diet had a secondary influence on the development of lesions since the cholesterol supplement was also associated with an increase in the incidence of lesions. The cholesterol supplement significantly increased the total plasma cholesterol level in all subgroups; the low density lipoprotein fraction (total cholesterol minus the high density lipoprotein fraction) was also elevated in seven of eight paired subgroups. Plasma free fatty acids and triglycerides were unaffected by the cholesterol supplement. The elevated total cholesterol and low density lipoprotein levels resulting from the cholesterol-enriched diet and the associated increase in the incidence of lesions was most prominent in mature males and females held in freshwater. Salinity had no demonstrable effect on lesion incidence, but the severity of lesions tended to be greater in freshwater fish. |
format |
Article in Journal/Newspaper |
author |
Farrell, A P Saunders, R L Freeman, H C Mommsen, T P |
author_facet |
Farrell, A P Saunders, R L Freeman, H C Mommsen, T P |
author_sort |
Farrell, A P |
title |
Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. |
title_short |
Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. |
title_full |
Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. |
title_fullStr |
Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. |
title_full_unstemmed |
Arteriosclerosis in Atlantic salmon. Effects of dietary cholesterol and maturation. |
title_sort |
arteriosclerosis in atlantic salmon. effects of dietary cholesterol and maturation. |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
1986 |
url |
http://dx.doi.org/10.1161/01.atv.6.4.453 https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.6.4.453 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Arteriosclerosis: An Official Journal of the American Heart Association, Inc. volume 6, issue 4, page 453-461 ISSN 0276-5047 |
op_doi |
https://doi.org/10.1161/01.atv.6.4.453 |
container_title |
Arteriosclerosis: An Official Journal of the American Heart Association, Inc. |
container_volume |
6 |
container_issue |
4 |
container_start_page |
453 |
op_container_end_page |
461 |
_version_ |
1788059820171984896 |