Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries
Objective: The aim of this study was to clarify whether antireflux surgery prevents laryngeal and pharyngeal squamous cell carcinoma. Summary Background Data: Gastroesophageal reflux disease (GERD) seems to increase the risk of laryngeal and pharyngeal squamous cell carcinoma. Methods: All-Nordic (D...
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Ovid Technologies (Wolters Kluwer Health)
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Online Access: | http://dx.doi.org/10.1097/sla.0000000000004423 https://journals.lww.com/10.1097/SLA.0000000000004423 |
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crovidcr:10.1097/sla.0000000000004423 2024-02-11T10:05:14+01:00 Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey Euler-Chelpin, My von Lagergren, Jesper 2020 http://dx.doi.org/10.1097/sla.0000000000004423 https://journals.lww.com/10.1097/SLA.0000000000004423 en eng Ovid Technologies (Wolters Kluwer Health) Annals of Surgery volume 276, issue 2, page e79-e85 ISSN 0003-4932 Surgery journal-article 2020 crovidcr https://doi.org/10.1097/sla.0000000000004423 2024-01-12T10:38:43Z Objective: The aim of this study was to clarify whether antireflux surgery prevents laryngeal and pharyngeal squamous cell carcinoma. Summary Background Data: Gastroesophageal reflux disease (GERD) seems to increase the risk of laryngeal and pharyngeal squamous cell carcinoma. Methods: All-Nordic (Denmark, Finland, Iceland, Norway, and Sweden) population-based cohort study of adults with documented GERD in 1980 to 2014. First, cancer risk after antireflux surgery was compared to the expected risk in the corresponding background population by calculating standardized incidence ratios (SIRs) with 95% confidence intervals (CIs). Second, cancer risk among antireflux surgery patients was compared to nonoperated GERD patients using multivariable Cox regression, providing hazard ratios (HR) with 95% CIs, adjusted for sex, age, calendar period, and diagnoses related to tobacco smoking, obesity, and alcohol overconsumption. Results: Among 814,230 GERD patients, 47,016 (5.8%) underwent antireflux surgery. The overall SIRs and HRs of the combined outcome laryngeal or pharyngeal squamous cell carcinoma (n=39) were decreased after antireflux surgery [SIR=0.62 (95% CI 0.44–0.85) and HR=0.55 (95% CI 0.38–0.80)]. The point estimates were further decreased >10 years after antireflux surgery [SIR=0.48 (95% CI 0.26–0.80) and HR=0.47 (95% CI 0.26–0.85)]. The risk estimates of laryngeal squamous cell carcinoma were particularly decreased >10 years after antireflux surgery [SIR=0.28 (95% CI 0.08–0.72) and HR=0.23 (95% CI 0.08–0.69)], whereas no such decrease over time after surgery was found for pharyngeal squamous cell carcinoma. Analyses of patients with severe GERD (reflux esophagitis or Barrett esophagus) showed similar results. Conclusion: Antireflux surgery may decrease the risk of laryngeal squamous cell carcinoma and possibly also of pharyngeal squamous cell carcinoma. Article in Journal/Newspaper Iceland Ovid Norway Barrett ENVELOPE(-126.773,-126.773,54.428,54.428) Gerd ENVELOPE(-45.750,-45.750,-60.666,-60.666) Annals of Surgery 276 2 e79 e85 |
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Surgery |
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Surgery Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey Euler-Chelpin, My von Lagergren, Jesper Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries |
topic_facet |
Surgery |
description |
Objective: The aim of this study was to clarify whether antireflux surgery prevents laryngeal and pharyngeal squamous cell carcinoma. Summary Background Data: Gastroesophageal reflux disease (GERD) seems to increase the risk of laryngeal and pharyngeal squamous cell carcinoma. Methods: All-Nordic (Denmark, Finland, Iceland, Norway, and Sweden) population-based cohort study of adults with documented GERD in 1980 to 2014. First, cancer risk after antireflux surgery was compared to the expected risk in the corresponding background population by calculating standardized incidence ratios (SIRs) with 95% confidence intervals (CIs). Second, cancer risk among antireflux surgery patients was compared to nonoperated GERD patients using multivariable Cox regression, providing hazard ratios (HR) with 95% CIs, adjusted for sex, age, calendar period, and diagnoses related to tobacco smoking, obesity, and alcohol overconsumption. Results: Among 814,230 GERD patients, 47,016 (5.8%) underwent antireflux surgery. The overall SIRs and HRs of the combined outcome laryngeal or pharyngeal squamous cell carcinoma (n=39) were decreased after antireflux surgery [SIR=0.62 (95% CI 0.44–0.85) and HR=0.55 (95% CI 0.38–0.80)]. The point estimates were further decreased >10 years after antireflux surgery [SIR=0.48 (95% CI 0.26–0.80) and HR=0.47 (95% CI 0.26–0.85)]. The risk estimates of laryngeal squamous cell carcinoma were particularly decreased >10 years after antireflux surgery [SIR=0.28 (95% CI 0.08–0.72) and HR=0.23 (95% CI 0.08–0.69)], whereas no such decrease over time after surgery was found for pharyngeal squamous cell carcinoma. Analyses of patients with severe GERD (reflux esophagitis or Barrett esophagus) showed similar results. Conclusion: Antireflux surgery may decrease the risk of laryngeal squamous cell carcinoma and possibly also of pharyngeal squamous cell carcinoma. |
format |
Article in Journal/Newspaper |
author |
Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey Euler-Chelpin, My von Lagergren, Jesper |
author_facet |
Yanes, Manar Santoni, Giola Maret-Ouda, John Ness-Jensen, Eivind Färkkilä, Martti Lynge, Elsebeth Pukkala, Eero Romundstad, Pål Tryggvadóttir, Laufey Euler-Chelpin, My von Lagergren, Jesper |
author_sort |
Yanes, Manar |
title |
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries |
title_short |
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries |
title_full |
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries |
title_fullStr |
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries |
title_full_unstemmed |
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries |
title_sort |
laryngeal and pharyngeal squamous cell carcinoma after antireflux surgery in the 5 nordic countries |
publisher |
Ovid Technologies (Wolters Kluwer Health) |
publishDate |
2020 |
url |
http://dx.doi.org/10.1097/sla.0000000000004423 https://journals.lww.com/10.1097/SLA.0000000000004423 |
long_lat |
ENVELOPE(-126.773,-126.773,54.428,54.428) ENVELOPE(-45.750,-45.750,-60.666,-60.666) |
geographic |
Norway Barrett Gerd |
geographic_facet |
Norway Barrett Gerd |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Annals of Surgery volume 276, issue 2, page e79-e85 ISSN 0003-4932 |
op_doi |
https://doi.org/10.1097/sla.0000000000004423 |
container_title |
Annals of Surgery |
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276 |
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2 |
container_start_page |
e79 |
op_container_end_page |
e85 |
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1790602140244246528 |