HYPERTENSION CHANGES THE ASSOCIATIONS BETWEEN HYPERURICEMIA AND OTHER CARDIOVASCULAR RISK FACTORS

• Published in: Journal of Hypertension
• Main Authors: Ruf, Ruslan, Grinshtein, Yuri, Shabalin, Vladimir
• Format: Article in Journal/Newspaper
• Language: English
• Published: Ovid Technologies (Wolters Kluwer Health) 2021
• Subjects: Krasnoyarsk Krai
• Online Access: http://dx.doi.org/10.1097/01.hjh.0000747212.13992.65; https://journals.lww.com/10.1097/01.hjh.0000747212.13992.65

Objective: The present study analyzed the interrelations of gender, hypertension, and associations between hyperuricemia and other cardiovascular risk factors. Design and method: Within the scope of the ESSE-RF study, we formed a randomized representative sample of 1603 inhabitants of Krasnoyarsk Krai aged 25–64. The protocol of the study provided the questionnaire, anthropometry, office blood pressure measurement, and biochemical blood analysis (lipids, glucose, creatinine, and uric acid). We registered hyperuricemia at serum uric acid levels higher than 360 micromoles/l in females and 400 micromoles/l in males. At measured blood pressure 140/90 mm Hg or more, or if a person took antihypertensive medications, we registered hypertension. Statistical calculations included descriptive statistics (the percentage of people having hypertension or hyperuricemia and 95% confidence intervals), chi-square to check group disparities for significance, and logistic regression to analyze the associations of hyperuricemia and other cardiovascular risk factors. We considered disparities and associations significant at p =<0.05. Results: We found 30.7% (28.4%; 33.0%) of the sample having hyperuricemia. It was more prevalent in males compared to females (49.9% (45.9%;53.9%) versus 18.2% (15.7%;20.7%); p < 0.001) and in hypertension compared to normal blood pressure (57.7% (53.3%;62.2%) versus 45.7% (42.7%;48.7%); p < 0.001). Regression analysis found more factors associated with hyperuricemia in males compared to females. The table shows additional disparities between normal blood pressure and hypertension. Conclusions: Krasnoyarsk Krai population demonstrated the high prevalence of hyperuricemia and its association with several metabolic and nutritional factors, including dyslipidemia and renal dysfunction. Hypertension and gender changed the amount and structure of the factors associated with hyperuricemia.