Histologic Comparison of Formocresol, Platelet-Rich Fibrin, and Hesperidin in Pulpotomy: A Randomized Trial in Dogs

• Published in: Nigerian Journal of Clinical Practice
• Main Authors: Metwally, NI, Mohamed, EAR, Ahmed, NA, Zaghloul, SA
• Format: Article in Journal/Newspaper
• Language: English
• Published: Medknow 2023
• Subjects: Canis lupus
• Online Access: http://dx.doi.org/10.4103/njcp.njcp_1731_21; https://journals.lww.com/10.4103/njcp.njcp_1731_21

A BSTRACT Aims: To histologically assess and compare formocresol (FC), platelet-rich fibrin (PRF), and hesperidin (HPN) as pulpotomy agents in dogs. Materials and Methods: Pulpotomy was attempted from the buccal surface (class V) of 48 teeth in three mongrel dogs ( Canis Lupus ). Cavities were randomly allocated for three groups (n = 16) according to the pulpotomy agent used; (group I: FC (control), group II: PRF, and group III: HPN). All cavities were then sealed with zinc oxide eugenol followed by resin-modified glass ionomer restoration. Two months later, dogs were euthanized; the specimens were obtained and prepared for histological assessment followed by statistical analysis. Results: HPN specimens showed the best dentin bridge formation and the least inflammatory signs and pulp disorganization. Followed without statistically significant difference by PRF ( P ≥ 0.05). Both of HPN and PRF, however, showed a significant difference statistically ( P ≤ 0.05) to FC that showed no dentin bridging with more pronounced inflammation, necrosis, and pulp disorganization. Conclusions: For pulpotomy, HPN and PRF seemed histologically to be good substitutes for FC in the dog model.