Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix
Objective: To evaluate the efficacy of treatment of hard-to-heal wounds of patients with ischaemia of the lower extremities, and compare an omega-3 wound matrix product (Kerecis, Iceland) with a standard dressing. Method: A single-centre, prospective, randomised, controlled clinical trial of patient...
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Language: | English |
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Mark Allen Group
2024
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Online Access: | http://dx.doi.org/10.12968/jowc.2024.33.5.348 http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2024.33.5.348 |
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crmarkallen:10.12968/jowc.2024.33.5.348 2024-05-19T07:42:56+00:00 Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix Lee, Yeon Ji Han, Hye Ju Shim, Hyung Sup 2024 http://dx.doi.org/10.12968/jowc.2024.33.5.348 http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2024.33.5.348 en eng Mark Allen Group Journal of Wound Care volume 33, issue 5, page 348-356 ISSN 0969-0700 2052-2916 journal-article 2024 crmarkallen https://doi.org/10.12968/jowc.2024.33.5.348 2024-05-02T09:27:31Z Objective: To evaluate the efficacy of treatment of hard-to-heal wounds of patients with ischaemia of the lower extremities, and compare an omega-3 wound matrix product (Kerecis, Iceland) with a standard dressing. Method: A single-centre, prospective, randomised, controlled clinical trial of patients with hard-to-heal wounds following three weeks of standard care was undertaken. The ischaemic condition of the wound was confirmed as a decreased transcutaneous oxygen pressure (TcPO 2 ) of <40mmHg. After randomising patients into either a case (omega-3 dressing) or a control group (standard dressing), the weekly decrease in wound area over 12 weeks and the number of patients that achieved complete wound closure were compared between the two groups. Patients with a TcPO 2 of ≤32mmHg were taken for further analysis of their wound in a severe ischaemic context. Results: A total of 28 patients were assigned to the case group and 22 patients to the control group. Over the course of 12 weeks, the wound area decreased more rapidly in the case group than the control group. Complete wound healing occurred in 82% of patients in the case group and 45% in the control group. Even in patients with a severe ischaemic wound with a TcPO 2 value of <32 mmHg, wound area decreased more rapidly in the case group than the control group. The proportions of re-epithelialised area in the case and control groups were 80.24% and 57.44%, respectively. Conclusion: Considering the more rapid decrease in wound area and complete healing ratio in the case group, application of a fish skin-derived matrix for treating lower-extremity hard-to-heal wounds, especially with impaired vascularity, would appear to be a good treatment option. Article in Journal/Newspaper Iceland Mark Allen Journal of Wound Care 33 5 348 356 |
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language |
English |
description |
Objective: To evaluate the efficacy of treatment of hard-to-heal wounds of patients with ischaemia of the lower extremities, and compare an omega-3 wound matrix product (Kerecis, Iceland) with a standard dressing. Method: A single-centre, prospective, randomised, controlled clinical trial of patients with hard-to-heal wounds following three weeks of standard care was undertaken. The ischaemic condition of the wound was confirmed as a decreased transcutaneous oxygen pressure (TcPO 2 ) of <40mmHg. After randomising patients into either a case (omega-3 dressing) or a control group (standard dressing), the weekly decrease in wound area over 12 weeks and the number of patients that achieved complete wound closure were compared between the two groups. Patients with a TcPO 2 of ≤32mmHg were taken for further analysis of their wound in a severe ischaemic context. Results: A total of 28 patients were assigned to the case group and 22 patients to the control group. Over the course of 12 weeks, the wound area decreased more rapidly in the case group than the control group. Complete wound healing occurred in 82% of patients in the case group and 45% in the control group. Even in patients with a severe ischaemic wound with a TcPO 2 value of <32 mmHg, wound area decreased more rapidly in the case group than the control group. The proportions of re-epithelialised area in the case and control groups were 80.24% and 57.44%, respectively. Conclusion: Considering the more rapid decrease in wound area and complete healing ratio in the case group, application of a fish skin-derived matrix for treating lower-extremity hard-to-heal wounds, especially with impaired vascularity, would appear to be a good treatment option. |
format |
Article in Journal/Newspaper |
author |
Lee, Yeon Ji Han, Hye Ju Shim, Hyung Sup |
spellingShingle |
Lee, Yeon Ji Han, Hye Ju Shim, Hyung Sup Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
author_facet |
Lee, Yeon Ji Han, Hye Ju Shim, Hyung Sup |
author_sort |
Lee, Yeon Ji |
title |
Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
title_short |
Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
title_full |
Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
title_fullStr |
Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
title_full_unstemmed |
Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
title_sort |
treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix |
publisher |
Mark Allen Group |
publishDate |
2024 |
url |
http://dx.doi.org/10.12968/jowc.2024.33.5.348 http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2024.33.5.348 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Wound Care volume 33, issue 5, page 348-356 ISSN 0969-0700 2052-2916 |
op_doi |
https://doi.org/10.12968/jowc.2024.33.5.348 |
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Journal of Wound Care |
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33 |
container_issue |
5 |
container_start_page |
348 |
op_container_end_page |
356 |
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1799482631938637824 |