Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort
Background Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. Objective To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast f...
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Online Access: | http://dx.doi.org/10.1136/thoraxjnl-2016-209429 https://syndication.highwire.org/content/doi/10.1136/thoraxjnl-2016-209429 |
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crjcrbmj:10.1136/thoraxjnl-2016-209429 2024-04-07T07:53:34+00:00 Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort Selby, Anna Munro, Alasdair Grimshaw, Kate E Cornelius, Victoria Keil, Thomas Grabenhenrich, Linus Clausen, Michael Dubakiene, Ruta Fiocchi, Alessandro Kowalski, Marek L Papadopoulos, Nikolaos G Reche, Marta Sigurdardottir, Sigurveig T Sprikkelman, Aline B Xepapadaki, Paraskevi Mills, E N Clare Beyer, Kirsten Roberts, Graham Food Standards Agency European Commission 2018 http://dx.doi.org/10.1136/thoraxjnl-2016-209429 https://syndication.highwire.org/content/doi/10.1136/thoraxjnl-2016-209429 en eng BMJ Thorax volume 73, issue 11, page 1049-1061 ISSN 0040-6376 1468-3296 Pulmonary and Respiratory Medicine journal-article 2018 crjcrbmj https://doi.org/10.1136/thoraxjnl-2016-209429 2024-03-08T02:41:49Z Background Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. Objective To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. Methods Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires. Poisson regression was used to assess risk factors for wheeze. Results 12 049 infants were recruited. Data from the second year of life were available in 8805 (73.1%). The prevalence of wheeze in the second year of life ranged from <2% in Lodz (Poland) and Vilnius (Lithuania) to 13.1% (95% CI 10.7% to 15.5%) in Southampton (UK) and 17.2% (95% CI 15.0% 19.5%) in Reykjavik (Iceland). In multivariable analysis, frequent lower respiratory tract infections in the first and second years of life (incidence rate ratio (IRR) 1.9 (95% CI 1.3 to 2.6) and 2.5 (95% CI 1.9 to3.4), respectively), postnatal maternal smoking (IRR 1.6, 95% CI 1.1 to 2.4), day care attendance (IRR 1.6, 95% CI 1.1 to 2.5) and male gender (IRR 1.3, 95% CI 1.0 to 1.7) were associated with wheeze. The strength of their association with wheeze differed between countries. Food allergy and breast feeding were not independently associated with wheeze. Conclusion The prevalence of early childhood wheeze varied considerably across Europe. Lower respiratory tract infections, day care attendance, postnatal smoke exposure and male gender are important risk factors. Further research is needed to identify additional modifiable risk factors that may differ between countries. Article in Journal/Newspaper Iceland The BMJ Thorax 73 11 1049 1061 |
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English |
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Pulmonary and Respiratory Medicine |
spellingShingle |
Pulmonary and Respiratory Medicine Selby, Anna Munro, Alasdair Grimshaw, Kate E Cornelius, Victoria Keil, Thomas Grabenhenrich, Linus Clausen, Michael Dubakiene, Ruta Fiocchi, Alessandro Kowalski, Marek L Papadopoulos, Nikolaos G Reche, Marta Sigurdardottir, Sigurveig T Sprikkelman, Aline B Xepapadaki, Paraskevi Mills, E N Clare Beyer, Kirsten Roberts, Graham Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
topic_facet |
Pulmonary and Respiratory Medicine |
description |
Background Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. Objective To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. Methods Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires. Poisson regression was used to assess risk factors for wheeze. Results 12 049 infants were recruited. Data from the second year of life were available in 8805 (73.1%). The prevalence of wheeze in the second year of life ranged from <2% in Lodz (Poland) and Vilnius (Lithuania) to 13.1% (95% CI 10.7% to 15.5%) in Southampton (UK) and 17.2% (95% CI 15.0% 19.5%) in Reykjavik (Iceland). In multivariable analysis, frequent lower respiratory tract infections in the first and second years of life (incidence rate ratio (IRR) 1.9 (95% CI 1.3 to 2.6) and 2.5 (95% CI 1.9 to3.4), respectively), postnatal maternal smoking (IRR 1.6, 95% CI 1.1 to 2.4), day care attendance (IRR 1.6, 95% CI 1.1 to 2.5) and male gender (IRR 1.3, 95% CI 1.0 to 1.7) were associated with wheeze. The strength of their association with wheeze differed between countries. Food allergy and breast feeding were not independently associated with wheeze. Conclusion The prevalence of early childhood wheeze varied considerably across Europe. Lower respiratory tract infections, day care attendance, postnatal smoke exposure and male gender are important risk factors. Further research is needed to identify additional modifiable risk factors that may differ between countries. |
author2 |
Food Standards Agency European Commission |
format |
Article in Journal/Newspaper |
author |
Selby, Anna Munro, Alasdair Grimshaw, Kate E Cornelius, Victoria Keil, Thomas Grabenhenrich, Linus Clausen, Michael Dubakiene, Ruta Fiocchi, Alessandro Kowalski, Marek L Papadopoulos, Nikolaos G Reche, Marta Sigurdardottir, Sigurveig T Sprikkelman, Aline B Xepapadaki, Paraskevi Mills, E N Clare Beyer, Kirsten Roberts, Graham |
author_facet |
Selby, Anna Munro, Alasdair Grimshaw, Kate E Cornelius, Victoria Keil, Thomas Grabenhenrich, Linus Clausen, Michael Dubakiene, Ruta Fiocchi, Alessandro Kowalski, Marek L Papadopoulos, Nikolaos G Reche, Marta Sigurdardottir, Sigurveig T Sprikkelman, Aline B Xepapadaki, Paraskevi Mills, E N Clare Beyer, Kirsten Roberts, Graham |
author_sort |
Selby, Anna |
title |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_short |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_full |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_fullStr |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_full_unstemmed |
Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort |
title_sort |
prevalence estimates and risk factors for early childhood wheeze across europe: the europrevall birth cohort |
publisher |
BMJ |
publishDate |
2018 |
url |
http://dx.doi.org/10.1136/thoraxjnl-2016-209429 https://syndication.highwire.org/content/doi/10.1136/thoraxjnl-2016-209429 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Thorax volume 73, issue 11, page 1049-1061 ISSN 0040-6376 1468-3296 |
op_doi |
https://doi.org/10.1136/thoraxjnl-2016-209429 |
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Thorax |
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73 |
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11 |
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1049 |
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1061 |
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1795669547293868032 |