Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial
Objectives Recent studies suggest that implementation of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis (RA) leads to higher inflammatory activity in seronegative compared with seropositive patients at time...
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Online Access: | http://dx.doi.org/10.1136/rmdopen-2018-000752 https://syndication.highwire.org/content/doi/10.1136/rmdopen-2018-000752 |
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crjcrbmj:10.1136/rmdopen-2018-000752 2024-10-13T14:05:13+00:00 Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial Nordberg, Lena Bugge Lillegraven, Siri Aga, Anna-Birgitte Sexton, Joseph Olsen, Inge Christoffer Lie, Elisabeth Berner Hammer, Hilde Uhlig, Till van der Heijde, Desirée Kvien, Tore K Haavardsholm, Espen A AbbVie UCB Norges Forskningsråd the Norwegian Rheumatism Association Pfizer Helse Sør-Øst RHF Merck Sharp and Dohme Roche 2018 http://dx.doi.org/10.1136/rmdopen-2018-000752 https://syndication.highwire.org/content/doi/10.1136/rmdopen-2018-000752 en eng BMJ RMD Open volume 4, issue 2, page e000752 ISSN 2056-5933 journal-article 2018 crjcrbmj https://doi.org/10.1136/rmdopen-2018-000752 2024-09-19T04:13:00Z Objectives Recent studies suggest that implementation of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis (RA) leads to higher inflammatory activity in seronegative compared with seropositive patients at time of diagnosis. Our aim was to compare the disease course in seronegative and seropositive patients classified according to the 2010 criteria. Methods DMARD-naïve patients with RA fulfilling the 2010 criteria were included in the treat-to-target ARCTIC trial and followed for 24 months. We stratified patients as seropositive (rheumatoid factor (RF)+, anticitrullinated protein antibodies (ACPA)+ or both) or seronegative (RF– and ACPA–) and compared disease activity, radiographic progression, treatment response and remission rates across groups. Results 230 patients were included with mean (SD) age 51.4 (13.7) years, and 61% were female. 34 patients (15%) were seronegative. At 24 months, disease activity measures, radiographic progression and remission rates were similar between groups, despite more inflammatory activity in seronegative patients at baseline. Treatment response was slower in seronegative compared with seropositive patients. The groups received similar treatment. Conclusion Our findings suggest that among patients with RA classified according to the 2010 ACR/EULAR criteria, seronegative patients respond well to modern treatment strategies. However, treatment response was somewhat slower in seronegative patients and radiographic progression was similar in seronegative and seropositive patients. Our results indicate that seronegative RA is not a mild form of the disease and requires intensive treat-to-target therapy similar to treatment of seropositive RA. Article in Journal/Newspaper Arctic The BMJ Arctic RMD Open 4 2 e000752 |
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Objectives Recent studies suggest that implementation of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis (RA) leads to higher inflammatory activity in seronegative compared with seropositive patients at time of diagnosis. Our aim was to compare the disease course in seronegative and seropositive patients classified according to the 2010 criteria. Methods DMARD-naïve patients with RA fulfilling the 2010 criteria were included in the treat-to-target ARCTIC trial and followed for 24 months. We stratified patients as seropositive (rheumatoid factor (RF)+, anticitrullinated protein antibodies (ACPA)+ or both) or seronegative (RF– and ACPA–) and compared disease activity, radiographic progression, treatment response and remission rates across groups. Results 230 patients were included with mean (SD) age 51.4 (13.7) years, and 61% were female. 34 patients (15%) were seronegative. At 24 months, disease activity measures, radiographic progression and remission rates were similar between groups, despite more inflammatory activity in seronegative patients at baseline. Treatment response was slower in seronegative compared with seropositive patients. The groups received similar treatment. Conclusion Our findings suggest that among patients with RA classified according to the 2010 ACR/EULAR criteria, seronegative patients respond well to modern treatment strategies. However, treatment response was somewhat slower in seronegative patients and radiographic progression was similar in seronegative and seropositive patients. Our results indicate that seronegative RA is not a mild form of the disease and requires intensive treat-to-target therapy similar to treatment of seropositive RA. |
author2 |
AbbVie UCB Norges Forskningsråd the Norwegian Rheumatism Association Pfizer Helse Sør-Øst RHF Merck Sharp and Dohme Roche |
format |
Article in Journal/Newspaper |
author |
Nordberg, Lena Bugge Lillegraven, Siri Aga, Anna-Birgitte Sexton, Joseph Olsen, Inge Christoffer Lie, Elisabeth Berner Hammer, Hilde Uhlig, Till van der Heijde, Desirée Kvien, Tore K Haavardsholm, Espen A |
spellingShingle |
Nordberg, Lena Bugge Lillegraven, Siri Aga, Anna-Birgitte Sexton, Joseph Olsen, Inge Christoffer Lie, Elisabeth Berner Hammer, Hilde Uhlig, Till van der Heijde, Desirée Kvien, Tore K Haavardsholm, Espen A Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial |
author_facet |
Nordberg, Lena Bugge Lillegraven, Siri Aga, Anna-Birgitte Sexton, Joseph Olsen, Inge Christoffer Lie, Elisabeth Berner Hammer, Hilde Uhlig, Till van der Heijde, Desirée Kvien, Tore K Haavardsholm, Espen A |
author_sort |
Nordberg, Lena Bugge |
title |
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial |
title_short |
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial |
title_full |
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial |
title_fullStr |
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial |
title_full_unstemmed |
Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial |
title_sort |
comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 acr/eular classification criteria in a treat-to-target setting: 2-year data from the arctic trial |
publisher |
BMJ |
publishDate |
2018 |
url |
http://dx.doi.org/10.1136/rmdopen-2018-000752 https://syndication.highwire.org/content/doi/10.1136/rmdopen-2018-000752 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
RMD Open volume 4, issue 2, page e000752 ISSN 2056-5933 |
op_doi |
https://doi.org/10.1136/rmdopen-2018-000752 |
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RMD Open |
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4 |
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2 |
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e000752 |
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1812811286298230784 |