Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure
Background Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. Methods The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 wit...
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crjcrbmj:10.1136/jech-2013-203661 2024-06-23T07:55:31+00:00 Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta 2014 http://dx.doi.org/10.1136/jech-2013-203661 https://syndication.highwire.org/content/doi/10.1136/jech-2013-203661 en eng BMJ Journal of Epidemiology and Community Health volume 68, issue 12, page 1161-1167 ISSN 0143-005X 1470-2738 journal-article 2014 crjcrbmj https://doi.org/10.1136/jech-2013-203661 2024-06-06T04:15:48Z Background Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. Methods The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 with data on birth weight, height and weight measurements until adolescence, systolic and diastolic BP at 31 years and several covariates. Structural equation modelling was used in the analysis. Results Negative direct effects of birth weight on adult systolic BP were observed (standardised regression coefficients: −0.08 (−0.14 to −0.03) in males and −0.04 (−0.09 to 0.01) in females, equalling −1.99 (−3.32 to −0.65) and −1.01 (−2.33 to 0.32) mm Hg/kg, respectively). Immediate postnatal growth was associated with adult BP only indirectly via growth later in life. In contrast, growth from adiposity rebound onwards had large direct, indirect and total effects on adult BP. Current body mass index was the strongest growth-related predictor of adult BP (0.36 (0.30 to 0.41) in males and 0.31 (0.24, 0.37) in females, equalling 1.29 (1.09 to 1.48) and 0.81 (0.63 to 0.99) mm Hg/(kg/m 2 ), respectively). Conclusions Our path analytical approach provides evidence for the importance of both fetal growth and postnatal growth, especially from adiposity rebound onwards, in determining adult BP, together with genetic predisposition and behavioural factors. Article in Journal/Newspaper Northern Finland The BMJ Journal of Epidemiology and Community Health 68 12 1161 1167 |
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description |
Background Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. Methods The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 with data on birth weight, height and weight measurements until adolescence, systolic and diastolic BP at 31 years and several covariates. Structural equation modelling was used in the analysis. Results Negative direct effects of birth weight on adult systolic BP were observed (standardised regression coefficients: −0.08 (−0.14 to −0.03) in males and −0.04 (−0.09 to 0.01) in females, equalling −1.99 (−3.32 to −0.65) and −1.01 (−2.33 to 0.32) mm Hg/kg, respectively). Immediate postnatal growth was associated with adult BP only indirectly via growth later in life. In contrast, growth from adiposity rebound onwards had large direct, indirect and total effects on adult BP. Current body mass index was the strongest growth-related predictor of adult BP (0.36 (0.30 to 0.41) in males and 0.31 (0.24, 0.37) in females, equalling 1.29 (1.09 to 1.48) and 0.81 (0.63 to 0.99) mm Hg/(kg/m 2 ), respectively). Conclusions Our path analytical approach provides evidence for the importance of both fetal growth and postnatal growth, especially from adiposity rebound onwards, in determining adult BP, together with genetic predisposition and behavioural factors. |
format |
Article in Journal/Newspaper |
author |
Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta |
spellingShingle |
Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
author_facet |
Kaakinen, Marika Sovio, Ulla Hartikainen, Anna-Liisa Pouta, Anneli Savolainen, Markku J Herzig, Karl-Heinz Elliott, Paul De Stavola, Bianca Läärä, Esa Järvelin, Marjo-Riitta |
author_sort |
Kaakinen, Marika |
title |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_short |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_full |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_fullStr |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_full_unstemmed |
Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
title_sort |
life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure |
publisher |
BMJ |
publishDate |
2014 |
url |
http://dx.doi.org/10.1136/jech-2013-203661 https://syndication.highwire.org/content/doi/10.1136/jech-2013-203661 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Journal of Epidemiology and Community Health volume 68, issue 12, page 1161-1167 ISSN 0143-005X 1470-2738 |
op_doi |
https://doi.org/10.1136/jech-2013-203661 |
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Journal of Epidemiology and Community Health |
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68 |
container_issue |
12 |
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1161 |
op_container_end_page |
1167 |
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1802648149049737216 |