Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study
Background The Rose Angina Questionnaire (RAQ) was constructed in the 1960s for assessing the population burden of angina. Studies have found that screening positivity by RAQ conferred an elevated risk of coronary heart disease (CHD). It is, however, not clear to what extent Rose angina represents e...
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crjcrbmj:10.1136/jech-2013-203642 2024-06-23T07:55:34+00:00 Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study Graff-Iversen, Sidsel Wilsgaard, Tom Mathiesen, Ellisiv B Njølstad, Inger Løchen, Maja-Lisa 2014 http://dx.doi.org/10.1136/jech-2013-203642 https://syndication.highwire.org/content/doi/10.1136/jech-2013-203642 en eng BMJ Journal of Epidemiology and Community Health volume 68, issue 8, page 754-759 ISSN 0143-005X 1470-2738 journal-article 2014 crjcrbmj https://doi.org/10.1136/jech-2013-203642 2024-06-06T04:15:34Z Background The Rose Angina Questionnaire (RAQ) was constructed in the 1960s for assessing the population burden of angina. Studies have found that screening positivity by RAQ conferred an elevated risk of coronary heart disease (CHD). It is, however, not clear to what extent Rose angina represents early CHD in relatively young adults who are free of known CHD. If representing CHD, Rose angina is expected to carry prognostic information in addition to the risk conferred by other risk factors. Methods The Tromsø Study is a population-based cohort study in Northern Norway. All men aged 20–54 years (n=8238) and women aged 20–49 years (n=8001), free of known cardiovascular disease (CVD), who participated in a survey 1979–1980, were followed throughout 2010 for incident myocardial infarction (MI), and for incident MI or stroke used as proxy for incident CVD. HRs were estimated using a Cox proportional hazard regression model. Results In age-adjusted analyses, Rose angina predicted MI and CVD in both sexes. The excess risk was substantially accounted for by CVD risk factors, leaving no significantly elevated MI risk above the risk explained by these factors (adjusted HR 1.31; 95% CI 0.95 to 1.80 in men, HR 1.20; 95% CI 0.69 to 2.10 in women). A similar pattern was seen for CVD (adjusted HR 1.16; 95% CI 0.87 to 1.55 in men and 1.30; 95% CI 0.82 to 2.06 in women). Conclusions Rose angina predicted MI and CVD in a 29-years’ follow-up of a relatively young population. Established CVD risk factors were important mediators. Article in Journal/Newspaper Northern Norway Tromsø The BMJ Norway Tromsø Journal of Epidemiology and Community Health 68 8 754 759 |
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crjcrbmj |
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English |
description |
Background The Rose Angina Questionnaire (RAQ) was constructed in the 1960s for assessing the population burden of angina. Studies have found that screening positivity by RAQ conferred an elevated risk of coronary heart disease (CHD). It is, however, not clear to what extent Rose angina represents early CHD in relatively young adults who are free of known CHD. If representing CHD, Rose angina is expected to carry prognostic information in addition to the risk conferred by other risk factors. Methods The Tromsø Study is a population-based cohort study in Northern Norway. All men aged 20–54 years (n=8238) and women aged 20–49 years (n=8001), free of known cardiovascular disease (CVD), who participated in a survey 1979–1980, were followed throughout 2010 for incident myocardial infarction (MI), and for incident MI or stroke used as proxy for incident CVD. HRs were estimated using a Cox proportional hazard regression model. Results In age-adjusted analyses, Rose angina predicted MI and CVD in both sexes. The excess risk was substantially accounted for by CVD risk factors, leaving no significantly elevated MI risk above the risk explained by these factors (adjusted HR 1.31; 95% CI 0.95 to 1.80 in men, HR 1.20; 95% CI 0.69 to 2.10 in women). A similar pattern was seen for CVD (adjusted HR 1.16; 95% CI 0.87 to 1.55 in men and 1.30; 95% CI 0.82 to 2.06 in women). Conclusions Rose angina predicted MI and CVD in a 29-years’ follow-up of a relatively young population. Established CVD risk factors were important mediators. |
format |
Article in Journal/Newspaper |
author |
Graff-Iversen, Sidsel Wilsgaard, Tom Mathiesen, Ellisiv B Njølstad, Inger Løchen, Maja-Lisa |
spellingShingle |
Graff-Iversen, Sidsel Wilsgaard, Tom Mathiesen, Ellisiv B Njølstad, Inger Løchen, Maja-Lisa Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study |
author_facet |
Graff-Iversen, Sidsel Wilsgaard, Tom Mathiesen, Ellisiv B Njølstad, Inger Løchen, Maja-Lisa |
author_sort |
Graff-Iversen, Sidsel |
title |
Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study |
title_short |
Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study |
title_full |
Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study |
title_fullStr |
Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study |
title_full_unstemmed |
Long-term cardiovascular consequences of Rose angina at age 20–54 years: 29-years’ follow-up of the Tromsø Study |
title_sort |
long-term cardiovascular consequences of rose angina at age 20–54 years: 29-years’ follow-up of the tromsø study |
publisher |
BMJ |
publishDate |
2014 |
url |
http://dx.doi.org/10.1136/jech-2013-203642 https://syndication.highwire.org/content/doi/10.1136/jech-2013-203642 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Northern Norway Tromsø |
genre_facet |
Northern Norway Tromsø |
op_source |
Journal of Epidemiology and Community Health volume 68, issue 8, page 754-759 ISSN 0143-005X 1470-2738 |
op_doi |
https://doi.org/10.1136/jech-2013-203642 |
container_title |
Journal of Epidemiology and Community Health |
container_volume |
68 |
container_issue |
8 |
container_start_page |
754 |
op_container_end_page |
759 |
_version_ |
1802648203488657408 |