Is the patient a fast or a slow acetylator?
The term ‘acetylator polymorphism’ describes genetically determined differences in ability to metabolise certain drugs by acetylation (see table). About 60% of people in Britain acetylate these drugs slowly (slow acetylator phenotype), while the remainder are rapid acetylators. Rapid acetylation is...
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crjcrbmj:10.1136/dtb.12.6.21 2024-06-23T07:52:32+00:00 Is the patient a fast or a slow acetylator? 1974 http://dx.doi.org/10.1136/dtb.12.6.21 https://syndication.highwire.org/content/doi/10.1136/dtb.12.6.21 en eng BMJ Drug and Therapeutics Bulletin volume 12, issue 6, page 21-22 ISSN 0012-6543 1755-5248 journal-article 1974 crjcrbmj https://doi.org/10.1136/dtb.12.6.21 2024-05-24T13:15:31Z The term ‘acetylator polymorphism’ describes genetically determined differences in ability to metabolise certain drugs by acetylation (see table). About 60% of people in Britain acetylate these drugs slowly (slow acetylator phenotype), while the remainder are rapid acetylators. Rapid acetylation is much more common among the Japanese, Chinese and Eskimos. Phenotypes may be identified by giving the patient a single dose of sulphadimidine and measuring the proportions of free and acetylated drug that appear in the plasma and urine. 1–3 But whether widespread acetylator phenotyping of patients will significantly improve their management is not yet clear. Article in Journal/Newspaper eskimo* The BMJ Drug and Therapeutics Bulletin 12 6 21 22 |
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English |
description |
The term ‘acetylator polymorphism’ describes genetically determined differences in ability to metabolise certain drugs by acetylation (see table). About 60% of people in Britain acetylate these drugs slowly (slow acetylator phenotype), while the remainder are rapid acetylators. Rapid acetylation is much more common among the Japanese, Chinese and Eskimos. Phenotypes may be identified by giving the patient a single dose of sulphadimidine and measuring the proportions of free and acetylated drug that appear in the plasma and urine. 1–3 But whether widespread acetylator phenotyping of patients will significantly improve their management is not yet clear. |
format |
Article in Journal/Newspaper |
title |
Is the patient a fast or a slow acetylator? |
spellingShingle |
Is the patient a fast or a slow acetylator? |
title_short |
Is the patient a fast or a slow acetylator? |
title_full |
Is the patient a fast or a slow acetylator? |
title_fullStr |
Is the patient a fast or a slow acetylator? |
title_full_unstemmed |
Is the patient a fast or a slow acetylator? |
title_sort |
is the patient a fast or a slow acetylator? |
publisher |
BMJ |
publishDate |
1974 |
url |
http://dx.doi.org/10.1136/dtb.12.6.21 https://syndication.highwire.org/content/doi/10.1136/dtb.12.6.21 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_source |
Drug and Therapeutics Bulletin volume 12, issue 6, page 21-22 ISSN 0012-6543 1755-5248 |
op_doi |
https://doi.org/10.1136/dtb.12.6.21 |
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Drug and Therapeutics Bulletin |
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12 |
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6 |
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21 |
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22 |
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1802643848933933056 |