Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns
Objectives Helicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. H pylori prevalence and gastric cancer rates are elevated among indigenous Arctic communities, but implementation of prevention strategies is hampered by insufficient information....
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crjcrbmj:10.1136/bmjopen-2013-003689 2024-09-15T17:35:23+00:00 Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns Cheung, Justin Goodman, Karen J Girgis, Safwat Bailey, Robert Morse, John Fedorak, Richard N Geary, Janis Fagan-Garcia, Katharine van Zanten, Sander Veldhuyzen 2014 http://dx.doi.org/10.1136/bmjopen-2013-003689 https://syndication.highwire.org/content/doi/10.1136/bmjopen-2013-003689 en eng BMJ BMJ Open volume 4, issue 1, page e003689 ISSN 2044-6055 2044-6055 journal-article 2014 crjcrbmj https://doi.org/10.1136/bmjopen-2013-003689 2024-08-01T04:14:49Z Objectives Helicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. H pylori prevalence and gastric cancer rates are elevated among indigenous Arctic communities, but implementation of prevention strategies is hampered by insufficient information. Some communities in northern Canada have advocated for H pylori prevention research. As a first step, community-driven research was undertaken to describe the H pylori- associated disease burden in concerned communities. Design Participants in this cross-sectional study completed a clinical interview and gastroscopy with gastric biopsies taken for histopathological examination in February 2008. Setting Study procedures were carried out at the health centre in Aklavik, Northwest Territories, Canada (population ∼600). Participants All residents of Aklavik were invited to complete a clinical interview and gastroscopy; 194 (58% female participants; 91% Aboriginal; age range 10–80 years) completed gastroscopy and had gastric biopsies taken. Primary and secondary outcome measures This analysis estimates the prevalence of gastric abnormalities detected by endoscopy and histopathology, and associations of demographic and clinical variables with H pylori prevalence. Results Among 194 participants with evaluable gastric biopsies, 66% were H pylori- positive on histology. Among H pylori -positive participants, prevalence was 94% for acute gastritis, 100% for chronic gastritis, 21% for gastric atrophy and 11% for intestinal metaplasia of the gastric mucosa, while chronic inflammation severity was mild in 9%, moderate in 47% and severe in 43%. In a multivariable model, H pylori prevalence was inversely associated with previous gastroscopy, previous H pylori therapy and aspirin use, and was positively associated with alcohol consumption. Conclusions In this population, H pylori -associated gastric histopathology shows a pattern compatible with elevated risk of gastric cancer. These findings demonstrate that local concern about ... Article in Journal/Newspaper Aklavik Northwest Territories The BMJ BMJ Open 4 1 e003689 |
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Objectives Helicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. H pylori prevalence and gastric cancer rates are elevated among indigenous Arctic communities, but implementation of prevention strategies is hampered by insufficient information. Some communities in northern Canada have advocated for H pylori prevention research. As a first step, community-driven research was undertaken to describe the H pylori- associated disease burden in concerned communities. Design Participants in this cross-sectional study completed a clinical interview and gastroscopy with gastric biopsies taken for histopathological examination in February 2008. Setting Study procedures were carried out at the health centre in Aklavik, Northwest Territories, Canada (population ∼600). Participants All residents of Aklavik were invited to complete a clinical interview and gastroscopy; 194 (58% female participants; 91% Aboriginal; age range 10–80 years) completed gastroscopy and had gastric biopsies taken. Primary and secondary outcome measures This analysis estimates the prevalence of gastric abnormalities detected by endoscopy and histopathology, and associations of demographic and clinical variables with H pylori prevalence. Results Among 194 participants with evaluable gastric biopsies, 66% were H pylori- positive on histology. Among H pylori -positive participants, prevalence was 94% for acute gastritis, 100% for chronic gastritis, 21% for gastric atrophy and 11% for intestinal metaplasia of the gastric mucosa, while chronic inflammation severity was mild in 9%, moderate in 47% and severe in 43%. In a multivariable model, H pylori prevalence was inversely associated with previous gastroscopy, previous H pylori therapy and aspirin use, and was positively associated with alcohol consumption. Conclusions In this population, H pylori -associated gastric histopathology shows a pattern compatible with elevated risk of gastric cancer. These findings demonstrate that local concern about ... |
format |
Article in Journal/Newspaper |
author |
Cheung, Justin Goodman, Karen J Girgis, Safwat Bailey, Robert Morse, John Fedorak, Richard N Geary, Janis Fagan-Garcia, Katharine van Zanten, Sander Veldhuyzen |
spellingShingle |
Cheung, Justin Goodman, Karen J Girgis, Safwat Bailey, Robert Morse, John Fedorak, Richard N Geary, Janis Fagan-Garcia, Katharine van Zanten, Sander Veldhuyzen Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns |
author_facet |
Cheung, Justin Goodman, Karen J Girgis, Safwat Bailey, Robert Morse, John Fedorak, Richard N Geary, Janis Fagan-Garcia, Katharine van Zanten, Sander Veldhuyzen |
author_sort |
Cheung, Justin |
title |
Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns |
title_short |
Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns |
title_full |
Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns |
title_fullStr |
Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns |
title_full_unstemmed |
Disease manifestations of Helicobacter pyloriinfection in Arctic Canada: using epidemiology to address community concerns |
title_sort |
disease manifestations of helicobacter pyloriinfection in arctic canada: using epidemiology to address community concerns |
publisher |
BMJ |
publishDate |
2014 |
url |
http://dx.doi.org/10.1136/bmjopen-2013-003689 https://syndication.highwire.org/content/doi/10.1136/bmjopen-2013-003689 |
genre |
Aklavik Northwest Territories |
genre_facet |
Aklavik Northwest Territories |
op_source |
BMJ Open volume 4, issue 1, page e003689 ISSN 2044-6055 2044-6055 |
op_doi |
https://doi.org/10.1136/bmjopen-2013-003689 |
container_title |
BMJ Open |
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4 |
container_issue |
1 |
container_start_page |
e003689 |
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1810454750956617728 |