Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada
Objective To determine the association between drinking water quality and rates of type 1 diabetes in the Newfoundland and Labrador (NL) population, which has one of the highest incidences of type 1 diabetes reported globally. Research design and methods The study used a community-based, case-contro...
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crjcrbmj:10.1136/bmjdrc-2017-000466 2024-05-19T07:44:16+00:00 Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada Chafe, Roger Aslanov, Rana Sarkar, Atanu Gregory, Peter Comeau, Alex Newhook, Leigh Anne Janeway Hospital Research Foundation Harris Centre RBC Drinking Water and Outreach Research Fund 2018 http://dx.doi.org/10.1136/bmjdrc-2017-000466 https://syndication.highwire.org/content/doi/10.1136/bmjdrc-2017-000466 en eng BMJ BMJ Open Diabetes Research & Care volume 6, issue 1, page e000466 ISSN 2052-4897 journal-article 2018 crjcrbmj https://doi.org/10.1136/bmjdrc-2017-000466 2024-05-02T09:26:42Z Objective To determine the association between drinking water quality and rates of type 1 diabetes in the Newfoundland and Labrador (NL) population, which has one of the highest incidences of type 1 diabetes reported globally. Research design and methods The study used a community-based, case-control design. We first calculated incidence rates of type 1 diabetes at the provincial, regional and community levels. The connection between incidence rates and components in public water supplies were then analyzed in three ways: to evaluate differences in water quality between communities with and without incident cases of type 1 diabetes, and to analyze the relationship between water quality and incidence rates of type 1 diabetes at both the community and regional levels. Results The provincial incidence of type 1 diabetes was 51.7/100 000 (0-14 year age group) for the period studied. In the community-based analysis, there were significant associations found between higher concentrations of arsenic (β=0.268, P=0.013) and fluoride (β=0.202, P=0.005) in drinking water and higher incidence of type 1 diabetes. In the regional analysis, barium (β=−0.478, P=0.009) and nickel (β=−0.354, P=0.050) concentrations were negatively associated with incidence of type 1 diabetes. Conclusions We confirmed the high incidence of type 1 diabetes in NL. We also found that concentrations of some components in drinking water were associated with higher incidence of type 1 diabetes, but no component was found to have a significant association across the three different levels of analysis performed. Article in Journal/Newspaper Newfoundland The BMJ BMJ Open Diabetes Research & Care 6 1 e000466 |
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Objective To determine the association between drinking water quality and rates of type 1 diabetes in the Newfoundland and Labrador (NL) population, which has one of the highest incidences of type 1 diabetes reported globally. Research design and methods The study used a community-based, case-control design. We first calculated incidence rates of type 1 diabetes at the provincial, regional and community levels. The connection between incidence rates and components in public water supplies were then analyzed in three ways: to evaluate differences in water quality between communities with and without incident cases of type 1 diabetes, and to analyze the relationship between water quality and incidence rates of type 1 diabetes at both the community and regional levels. Results The provincial incidence of type 1 diabetes was 51.7/100 000 (0-14 year age group) for the period studied. In the community-based analysis, there were significant associations found between higher concentrations of arsenic (β=0.268, P=0.013) and fluoride (β=0.202, P=0.005) in drinking water and higher incidence of type 1 diabetes. In the regional analysis, barium (β=−0.478, P=0.009) and nickel (β=−0.354, P=0.050) concentrations were negatively associated with incidence of type 1 diabetes. Conclusions We confirmed the high incidence of type 1 diabetes in NL. We also found that concentrations of some components in drinking water were associated with higher incidence of type 1 diabetes, but no component was found to have a significant association across the three different levels of analysis performed. |
author2 |
Janeway Hospital Research Foundation Harris Centre RBC Drinking Water and Outreach Research Fund |
format |
Article in Journal/Newspaper |
author |
Chafe, Roger Aslanov, Rana Sarkar, Atanu Gregory, Peter Comeau, Alex Newhook, Leigh Anne |
spellingShingle |
Chafe, Roger Aslanov, Rana Sarkar, Atanu Gregory, Peter Comeau, Alex Newhook, Leigh Anne Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada |
author_facet |
Chafe, Roger Aslanov, Rana Sarkar, Atanu Gregory, Peter Comeau, Alex Newhook, Leigh Anne |
author_sort |
Chafe, Roger |
title |
Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada |
title_short |
Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada |
title_full |
Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada |
title_fullStr |
Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada |
title_full_unstemmed |
Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada |
title_sort |
association of type 1 diabetes and concentrations of drinking water components in newfoundland and labrador, canada |
publisher |
BMJ |
publishDate |
2018 |
url |
http://dx.doi.org/10.1136/bmjdrc-2017-000466 https://syndication.highwire.org/content/doi/10.1136/bmjdrc-2017-000466 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
BMJ Open Diabetes Research & Care volume 6, issue 1, page e000466 ISSN 2052-4897 |
op_doi |
https://doi.org/10.1136/bmjdrc-2017-000466 |
container_title |
BMJ Open Diabetes Research & Care |
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6 |
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1 |
container_start_page |
e000466 |
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1799484027204272128 |