Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study
Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected dat...
Published in: | British Journal of Ophthalmology |
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Online Access: | http://dx.doi.org/10.1136/bjophthalmol-2019-314803 https://syndication.highwire.org/content/doi/10.1136/bjophthalmol-2019-314803 |
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crjcrbmj:10.1136/bjophthalmol-2019-314803 2024-09-15T18:25:41+00:00 Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna Mary and Georg Ehrnrooth Foundation Silmäsäätiö Pohjois-Suomen Terveydenhuollon Tukisäätiö Suomen Lääketieteen Säätiö Glaukooma Tukisäätiö LUX 2020 http://dx.doi.org/10.1136/bjophthalmol-2019-314803 https://syndication.highwire.org/content/doi/10.1136/bjophthalmol-2019-314803 en eng BMJ British Journal of Ophthalmology volume 104, issue 10, page 1435-1442 ISSN 0007-1161 1468-2079 journal-article 2020 crjcrbmj https://doi.org/10.1136/bjophthalmol-2019-314803 2024-07-11T04:17:06Z Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography. Results Data from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all). Conclusions Increased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases. Article in Journal/Newspaper Northern Finland The BMJ British Journal of Ophthalmology 104 10 1435 1442 |
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The BMJ |
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crjcrbmj |
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English |
description |
Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography. Results Data from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all). Conclusions Increased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases. |
author2 |
Mary and Georg Ehrnrooth Foundation Silmäsäätiö Pohjois-Suomen Terveydenhuollon Tukisäätiö Suomen Lääketieteen Säätiö Glaukooma Tukisäätiö LUX |
format |
Article in Journal/Newspaper |
author |
Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna |
spellingShingle |
Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
author_facet |
Geneid, Mohamed I Uusitalo, Janne J Leiviskä, Ilmari L Saarela, Ville O Liinamaa, M Johanna |
author_sort |
Geneid, Mohamed I |
title |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_short |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_full |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_fullStr |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_full_unstemmed |
Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study |
title_sort |
relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged caucasians: the northern finland birth cohort eye study |
publisher |
BMJ |
publishDate |
2020 |
url |
http://dx.doi.org/10.1136/bjophthalmol-2019-314803 https://syndication.highwire.org/content/doi/10.1136/bjophthalmol-2019-314803 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
British Journal of Ophthalmology volume 104, issue 10, page 1435-1442 ISSN 0007-1161 1468-2079 |
op_doi |
https://doi.org/10.1136/bjophthalmol-2019-314803 |
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British Journal of Ophthalmology |
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104 |
container_issue |
10 |
container_start_page |
1435 |
op_container_end_page |
1442 |
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1810466174302945280 |