Diagnostic performance of modern imaging instruments in glaucoma screening
Aim To evaluate the applicability of imaging devices (spectral-domain optical coherence tomography (Cirrus SD-OCT), scanning laser polarimetry (GDx) and scanning laser ophthalmoscopy (Heidelberg Retinal Tomograph, HRT3)) for glaucoma screening in a middle-aged unselected population. Methods Particip...
Published in: | British Journal of Ophthalmology |
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Online Access: | http://dx.doi.org/10.1136/bjophthalmol-2019-314795 https://syndication.highwire.org/content/doi/10.1136/bjophthalmol-2019-314795 |
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crjcrbmj:10.1136/bjophthalmol-2019-314795 2024-09-30T14:40:08+00:00 Diagnostic performance of modern imaging instruments in glaucoma screening Karvonen, Elina Stoor, Katri Luodonpää, Marja Hägg, Pasi Lintonen, Timo Liinamaa, Johanna Tuulonen, Anja Saarela, Ville Glaukooma Tukisäätiö Lux Foundation, Finland Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital, Finland Oulu University Hospital European Regional Development Fund Oulun Yliopisto Silmäsäätiö Foundation, Finland 2020 http://dx.doi.org/10.1136/bjophthalmol-2019-314795 https://syndication.highwire.org/content/doi/10.1136/bjophthalmol-2019-314795 en eng BMJ British Journal of Ophthalmology volume 104, issue 10, page 1399-1405 ISSN 0007-1161 1468-2079 journal-article 2020 crjcrbmj https://doi.org/10.1136/bjophthalmol-2019-314795 2024-09-19T04:13:02Z Aim To evaluate the applicability of imaging devices (spectral-domain optical coherence tomography (Cirrus SD-OCT), scanning laser polarimetry (GDx) and scanning laser ophthalmoscopy (Heidelberg Retinal Tomograph, HRT3)) for glaucoma screening in a middle-aged unselected population. Methods Participants of the population-based Northern Finland Birth Cohort Eye Study, aged 45 to 49 years, underwent a comprehensive eye examination including modern imaging with five methods (retinal nerve fibre layer (RNFL) and macular ganglion cell layer +inner plexiform layer (GCIPL) analysis and their combination with SD-OCT, GDx and HRT). The performance of the automated classification of the imaging devices was assessed using a clinical glaucoma diagnosis as reference, that is, the ‘2 out of 3’ rule based on the evaluation of optic nerve head and RNFL photographs and visual fields. Results We examined 6060 eyes of 3039 subjects; in the clinical evaluation, glaucomatous damage was found in 33 subjects (1.1%) in 43 eyes. The following sensitivities were obtained; RNFL analysis (53%), GCIPL analysis (50%), OCT combination analysis (61%), GDx (56%) and HRT (31%) with corresponding specificities of 95%, 92%, 90%, 88% and 96%. The area under the curve values were 0.76, 0.73, 0.75, 0.75 and 0.73, respectively. Post-test probabilities of glaucoma after positive imaging finding with each of these methods in this unselected population were 11%, 7%, 6%, 5% and 7%, respectively. Conclusion Screening capabilities of the OCT, GDx and HRT were rather similar. The accuracy of all evaluated parameters was only moderate and thus screening with these parameters alone is not reliable. Article in Journal/Newspaper Northern Finland The BMJ British Journal of Ophthalmology 104 10 1399 1405 |
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The BMJ |
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crjcrbmj |
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description |
Aim To evaluate the applicability of imaging devices (spectral-domain optical coherence tomography (Cirrus SD-OCT), scanning laser polarimetry (GDx) and scanning laser ophthalmoscopy (Heidelberg Retinal Tomograph, HRT3)) for glaucoma screening in a middle-aged unselected population. Methods Participants of the population-based Northern Finland Birth Cohort Eye Study, aged 45 to 49 years, underwent a comprehensive eye examination including modern imaging with five methods (retinal nerve fibre layer (RNFL) and macular ganglion cell layer +inner plexiform layer (GCIPL) analysis and their combination with SD-OCT, GDx and HRT). The performance of the automated classification of the imaging devices was assessed using a clinical glaucoma diagnosis as reference, that is, the ‘2 out of 3’ rule based on the evaluation of optic nerve head and RNFL photographs and visual fields. Results We examined 6060 eyes of 3039 subjects; in the clinical evaluation, glaucomatous damage was found in 33 subjects (1.1%) in 43 eyes. The following sensitivities were obtained; RNFL analysis (53%), GCIPL analysis (50%), OCT combination analysis (61%), GDx (56%) and HRT (31%) with corresponding specificities of 95%, 92%, 90%, 88% and 96%. The area under the curve values were 0.76, 0.73, 0.75, 0.75 and 0.73, respectively. Post-test probabilities of glaucoma after positive imaging finding with each of these methods in this unselected population were 11%, 7%, 6%, 5% and 7%, respectively. Conclusion Screening capabilities of the OCT, GDx and HRT were rather similar. The accuracy of all evaluated parameters was only moderate and thus screening with these parameters alone is not reliable. |
author2 |
Glaukooma Tukisäätiö Lux Foundation, Finland Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital, Finland Oulu University Hospital European Regional Development Fund Oulun Yliopisto Silmäsäätiö Foundation, Finland |
format |
Article in Journal/Newspaper |
author |
Karvonen, Elina Stoor, Katri Luodonpää, Marja Hägg, Pasi Lintonen, Timo Liinamaa, Johanna Tuulonen, Anja Saarela, Ville |
spellingShingle |
Karvonen, Elina Stoor, Katri Luodonpää, Marja Hägg, Pasi Lintonen, Timo Liinamaa, Johanna Tuulonen, Anja Saarela, Ville Diagnostic performance of modern imaging instruments in glaucoma screening |
author_facet |
Karvonen, Elina Stoor, Katri Luodonpää, Marja Hägg, Pasi Lintonen, Timo Liinamaa, Johanna Tuulonen, Anja Saarela, Ville |
author_sort |
Karvonen, Elina |
title |
Diagnostic performance of modern imaging instruments in glaucoma screening |
title_short |
Diagnostic performance of modern imaging instruments in glaucoma screening |
title_full |
Diagnostic performance of modern imaging instruments in glaucoma screening |
title_fullStr |
Diagnostic performance of modern imaging instruments in glaucoma screening |
title_full_unstemmed |
Diagnostic performance of modern imaging instruments in glaucoma screening |
title_sort |
diagnostic performance of modern imaging instruments in glaucoma screening |
publisher |
BMJ |
publishDate |
2020 |
url |
http://dx.doi.org/10.1136/bjophthalmol-2019-314795 https://syndication.highwire.org/content/doi/10.1136/bjophthalmol-2019-314795 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
British Journal of Ophthalmology volume 104, issue 10, page 1399-1405 ISSN 0007-1161 1468-2079 |
op_doi |
https://doi.org/10.1136/bjophthalmol-2019-314795 |
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British Journal of Ophthalmology |
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104 |
container_issue |
10 |
container_start_page |
1399 |
op_container_end_page |
1405 |
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1811642657019002880 |