Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada
An 88-year-old Inuit man from Northern Canada presented with an extensive skin rash associated with numerous violaceous skin nodules on his palms and lower extremities. Biopsy of a skin nodule revealed Kaposi’s sarcoma (KS), a human herpesvirus 8 (HHV8)-associated malignancy, whereas biopsy of the e...
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crjcrbmj:10.1136/bcr-2020-238644 2024-02-11T10:05:18+01:00 Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada Bedier, Helbies Lin, John Julien, Louis-André Routy, Jean-Pierre 2021 http://dx.doi.org/10.1136/bcr-2020-238644 https://syndication.highwire.org/content/doi/10.1136/bcr-2020-238644 en eng BMJ http://creativecommons.org/licenses/by-nc/4.0/ BMJ Case Reports volume 14, issue 1, page e238644 ISSN 1757-790X General Medicine journal-article 2021 crjcrbmj https://doi.org/10.1136/bcr-2020-238644 2024-01-26T10:13:15Z An 88-year-old Inuit man from Northern Canada presented with an extensive skin rash associated with numerous violaceous skin nodules on his palms and lower extremities. Biopsy of a skin nodule revealed Kaposi’s sarcoma (KS), a human herpesvirus 8 (HHV8)-associated malignancy, whereas biopsy of the erythematous skin showed an atypical infiltrate of CD4-positive T-cells that, together with TCR gene rearrangement and presence of clonal T-cells in peripheral blood by flow cytometry, was consistent with a T-cell lymphoma, mycosis fungoides (MF) subtype. Serology was negative for HIV and HTLV-I/II and no immunodeficiency syndrome was identified. The patient was successfully treated with an oral retinoid for KS, and with topical hydrocortisone and ultraviolet B (UVB) phototherapy for MF. This case highlights the existence of HHV8-related lesions in native persons of Northern Canada, and also that MF-induced immunosuppression combined with immunosenescence may play a role in the development of non-HIV-related KS. Article in Journal/Newspaper inuit The BMJ Canada BMJ Case Reports 14 1 e238644 |
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The BMJ |
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crjcrbmj |
language |
English |
topic |
General Medicine |
spellingShingle |
General Medicine Bedier, Helbies Lin, John Julien, Louis-André Routy, Jean-Pierre Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada |
topic_facet |
General Medicine |
description |
An 88-year-old Inuit man from Northern Canada presented with an extensive skin rash associated with numerous violaceous skin nodules on his palms and lower extremities. Biopsy of a skin nodule revealed Kaposi’s sarcoma (KS), a human herpesvirus 8 (HHV8)-associated malignancy, whereas biopsy of the erythematous skin showed an atypical infiltrate of CD4-positive T-cells that, together with TCR gene rearrangement and presence of clonal T-cells in peripheral blood by flow cytometry, was consistent with a T-cell lymphoma, mycosis fungoides (MF) subtype. Serology was negative for HIV and HTLV-I/II and no immunodeficiency syndrome was identified. The patient was successfully treated with an oral retinoid for KS, and with topical hydrocortisone and ultraviolet B (UVB) phototherapy for MF. This case highlights the existence of HHV8-related lesions in native persons of Northern Canada, and also that MF-induced immunosuppression combined with immunosenescence may play a role in the development of non-HIV-related KS. |
format |
Article in Journal/Newspaper |
author |
Bedier, Helbies Lin, John Julien, Louis-André Routy, Jean-Pierre |
author_facet |
Bedier, Helbies Lin, John Julien, Louis-André Routy, Jean-Pierre |
author_sort |
Bedier, Helbies |
title |
Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada |
title_short |
Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada |
title_full |
Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada |
title_fullStr |
Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada |
title_full_unstemmed |
Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada |
title_sort |
concurrent development of hiv-negative kaposi’s sarcoma and mycosis fungoides in an elderly inuit from canada |
publisher |
BMJ |
publishDate |
2021 |
url |
http://dx.doi.org/10.1136/bcr-2020-238644 https://syndication.highwire.org/content/doi/10.1136/bcr-2020-238644 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
inuit |
genre_facet |
inuit |
op_source |
BMJ Case Reports volume 14, issue 1, page e238644 ISSN 1757-790X |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1136/bcr-2020-238644 |
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BMJ Case Reports |
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14 |
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1 |
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e238644 |
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1790602262373990400 |