Season and region of birth as risk factors for coeliac disease a key to the aetiology?
Background Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several envi...
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crjcrbmj:10.1136/archdischild-2015-310122 2024-04-07T07:54:55+00:00 Season and region of birth as risk factors for coeliac disease a key to the aetiology? Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof 2016 http://dx.doi.org/10.1136/archdischild-2015-310122 https://syndication.highwire.org/content/doi/10.1136/archdischild-2015-310122 en eng BMJ Archives of Disease in Childhood volume 101, issue 12, page 1114-1118 ISSN 0003-9888 1468-2044 Pediatrics, Perinatology and Child Health journal-article 2016 crjcrbmj https://doi.org/10.1136/archdischild-2015-310122 2024-03-08T02:43:10Z Background Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several environmental factors are considered. Methods A nationwide prospective cohort longitudinal study was conducted consisting of 1 912 204 children aged 0–14.9 years born in Sweden from 1991 to 2009. A total of 6569 children were diagnosed with biopsy-verified CD from 47 paediatric departments. Using Cox regression, we examined the association between CD diagnosis and season of birth, region of birth and year of birth. Results Overall, CD risk was higher for children born during spring, summer and autumn as compared with children born during winter: adjusted HR for spring 1.08 (95% CI 1.01 to 1.16), summer 1.10 (95% CI 1.03 to 1.18) and autumn 1.10 (95% CI 1.02 to 1.18). Increased CD risk was highest if born in the south, followed by central Sweden when compared with children born in northern Sweden. Children diagnosed at <2 years had an increased CD risk if born in spring while those diagnosed at 2–14.9 years the risk was increased for summer and autumn births. The birth cohort of 1991–1996 had increased CD risk if born during spring, for the 1997–2002 birth cohort the risk increased for summer and autumn births, while for the birth cohort of 2003–2009 the risk was increased if born during autumn. Conclusions Season of birth and region of birth are independently and jointly associated with increased risk of developing CD during the first 15 years of life. Seasonal variation in infectious load is the likely explanation. Article in Journal/Newspaper Northern Sweden The BMJ Archives of Disease in Childhood 101 12 1114 1118 |
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English |
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Pediatrics, Perinatology and Child Health |
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Pediatrics, Perinatology and Child Health Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof Season and region of birth as risk factors for coeliac disease a key to the aetiology? |
topic_facet |
Pediatrics, Perinatology and Child Health |
description |
Background Coeliac disease (CD) incidence has increased in recent decades, characterised by variations according to sex, age at diagnosis, year of birth, month of birth and region of birth. Genetic susceptibility and exposure to gluten are the necessary factors in CD aetiology, although several environmental factors are considered. Methods A nationwide prospective cohort longitudinal study was conducted consisting of 1 912 204 children aged 0–14.9 years born in Sweden from 1991 to 2009. A total of 6569 children were diagnosed with biopsy-verified CD from 47 paediatric departments. Using Cox regression, we examined the association between CD diagnosis and season of birth, region of birth and year of birth. Results Overall, CD risk was higher for children born during spring, summer and autumn as compared with children born during winter: adjusted HR for spring 1.08 (95% CI 1.01 to 1.16), summer 1.10 (95% CI 1.03 to 1.18) and autumn 1.10 (95% CI 1.02 to 1.18). Increased CD risk was highest if born in the south, followed by central Sweden when compared with children born in northern Sweden. Children diagnosed at <2 years had an increased CD risk if born in spring while those diagnosed at 2–14.9 years the risk was increased for summer and autumn births. The birth cohort of 1991–1996 had increased CD risk if born during spring, for the 1997–2002 birth cohort the risk increased for summer and autumn births, while for the birth cohort of 2003–2009 the risk was increased if born during autumn. Conclusions Season of birth and region of birth are independently and jointly associated with increased risk of developing CD during the first 15 years of life. Seasonal variation in infectious load is the likely explanation. |
format |
Article in Journal/Newspaper |
author |
Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof |
author_facet |
Namatovu, Fredinah Lindkvist, Marie Olsson, Cecilia Ivarsson, Anneli Sandström, Olof |
author_sort |
Namatovu, Fredinah |
title |
Season and region of birth as risk factors for coeliac disease a key to the aetiology? |
title_short |
Season and region of birth as risk factors for coeliac disease a key to the aetiology? |
title_full |
Season and region of birth as risk factors for coeliac disease a key to the aetiology? |
title_fullStr |
Season and region of birth as risk factors for coeliac disease a key to the aetiology? |
title_full_unstemmed |
Season and region of birth as risk factors for coeliac disease a key to the aetiology? |
title_sort |
season and region of birth as risk factors for coeliac disease a key to the aetiology? |
publisher |
BMJ |
publishDate |
2016 |
url |
http://dx.doi.org/10.1136/archdischild-2015-310122 https://syndication.highwire.org/content/doi/10.1136/archdischild-2015-310122 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Archives of Disease in Childhood volume 101, issue 12, page 1114-1118 ISSN 0003-9888 1468-2044 |
op_doi |
https://doi.org/10.1136/archdischild-2015-310122 |
container_title |
Archives of Disease in Childhood |
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101 |
container_issue |
12 |
container_start_page |
1114 |
op_container_end_page |
1118 |
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1795671747139207168 |