POS1312 ANALYSIS OF INTERFERON TYPE I SIGNATURE IN JUVENILE DERMATOMYOSITIS

• Published in: Annals of the Rheumatic Diseases
• Main Authors: Raupov, R., Suspitsin, E., Mulkidzhan, R., Kostik, M.
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMJ 2022
• Subjects: General Biochemistry, Genetics and Molecular Biology; Immunology; Immunology and Allergy; Rheumatology; Rigolet
• Online Access: http://dx.doi.org/10.1136/annrheumdis-2022-eular.3292; https://syndication.highwire.org/content/doi/10.1136/annrheumdis-2022-eular.3292

Background the crucial role of hyperactivation IFN I signaling pathway has been proved in the pathogenesis of dermatomyositis. IFN I genes and chemokines activity vary according to subtype of inflammatory myopathies. IFN type 1 signature could be measured using different genes in the blood, skin and...