Adaptive immune response in residents of the Russian Arctic zone and South Ossetia
Abstract The human body in adverse living conditions, such as in the Arctic, goes through the risk of impairing functional systems including the immune system. These disturbances lead to appear states of weakness or hyperactivity of the organism protective function. This study investigates the state...
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crioppubl:10.1088/1755-1315/302/1/012076 2024-06-02T08:01:19+00:00 Adaptive immune response in residents of the Russian Arctic zone and South Ossetia Kabbani, M S Shchegoleva, L S 2019 http://dx.doi.org/10.1088/1755-1315/302/1/012076 https://iopscience.iop.org/article/10.1088/1755-1315/302/1/012076/pdf https://iopscience.iop.org/article/10.1088/1755-1315/302/1/012076 unknown IOP Publishing http://creativecommons.org/licenses/by/3.0/ https://iopscience.iop.org/info/page/text-and-data-mining IOP Conference Series: Earth and Environmental Science volume 302, issue 1, page 012076 ISSN 1755-1307 1755-1315 journal-article 2019 crioppubl https://doi.org/10.1088/1755-1315/302/1/012076 2024-05-07T13:59:39Z Abstract The human body in adverse living conditions, such as in the Arctic, goes through the risk of impairing functional systems including the immune system. These disturbances lead to appear states of weakness or hyperactivity of the organism protective function. This study investigates the state of the adaptive immune response of 40-60-year-old women living in the Russian Arctic and South Ossetia. The indirect immunoperoxidase assay with monoclonal antibodies was used to analyze the immune parameters of lymphoid subpopulations in 40-60-year-old women living in Nadym city in the Yamalo-Nenets Autonomous Okrug and in Tskhinval city in South Ossetia. After analyzing the received data, the deficiency of mature T-lymphocytes (CD3 + ) was found in 96-100% of the examined individuals. We also revealed a decrease in the concentration of T-helper (CD4 + ) and B-activated (HLA-DR + ) cells in 30% of Arctic zone cases and in 50% of the southern zone cases on the background of increasing concentrations of cytotoxic T-lymphocytes. A deficiency of cells with apoptosis receptors (CD95 + ) was registered mainly in Tskhinval women (80%). Thus, it can be assumed that the deficiency of mature lymphoid cells with a receptor (CD3 + ) leads to disruption of the T-cell pool of the immune response and delay of the adaptive immune response overall. The increase in the cytotoxic T-lymphocyte count indicates the stress state of the adaptive immune component to compensate for the lack of T-helper and B-activated cells concentration. Additional comprehensive studies are needed to identify environmental factors having a significant impact on the mechanism of the adaptive immune response development. Article in Journal/Newspaper Arctic nenets Nenets Autonomous Okrug Yamalo Nenets Yamalo-Nenets Autonomous Okrug IOP Publishing Arctic Nadym ENVELOPE(72.517,72.517,65.533,65.533) IOP Conference Series: Earth and Environmental Science 302 012076 |
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IOP Publishing |
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Abstract The human body in adverse living conditions, such as in the Arctic, goes through the risk of impairing functional systems including the immune system. These disturbances lead to appear states of weakness or hyperactivity of the organism protective function. This study investigates the state of the adaptive immune response of 40-60-year-old women living in the Russian Arctic and South Ossetia. The indirect immunoperoxidase assay with monoclonal antibodies was used to analyze the immune parameters of lymphoid subpopulations in 40-60-year-old women living in Nadym city in the Yamalo-Nenets Autonomous Okrug and in Tskhinval city in South Ossetia. After analyzing the received data, the deficiency of mature T-lymphocytes (CD3 + ) was found in 96-100% of the examined individuals. We also revealed a decrease in the concentration of T-helper (CD4 + ) and B-activated (HLA-DR + ) cells in 30% of Arctic zone cases and in 50% of the southern zone cases on the background of increasing concentrations of cytotoxic T-lymphocytes. A deficiency of cells with apoptosis receptors (CD95 + ) was registered mainly in Tskhinval women (80%). Thus, it can be assumed that the deficiency of mature lymphoid cells with a receptor (CD3 + ) leads to disruption of the T-cell pool of the immune response and delay of the adaptive immune response overall. The increase in the cytotoxic T-lymphocyte count indicates the stress state of the adaptive immune component to compensate for the lack of T-helper and B-activated cells concentration. Additional comprehensive studies are needed to identify environmental factors having a significant impact on the mechanism of the adaptive immune response development. |
format |
Article in Journal/Newspaper |
author |
Kabbani, M S Shchegoleva, L S |
spellingShingle |
Kabbani, M S Shchegoleva, L S Adaptive immune response in residents of the Russian Arctic zone and South Ossetia |
author_facet |
Kabbani, M S Shchegoleva, L S |
author_sort |
Kabbani, M S |
title |
Adaptive immune response in residents of the Russian Arctic zone and South Ossetia |
title_short |
Adaptive immune response in residents of the Russian Arctic zone and South Ossetia |
title_full |
Adaptive immune response in residents of the Russian Arctic zone and South Ossetia |
title_fullStr |
Adaptive immune response in residents of the Russian Arctic zone and South Ossetia |
title_full_unstemmed |
Adaptive immune response in residents of the Russian Arctic zone and South Ossetia |
title_sort |
adaptive immune response in residents of the russian arctic zone and south ossetia |
publisher |
IOP Publishing |
publishDate |
2019 |
url |
http://dx.doi.org/10.1088/1755-1315/302/1/012076 https://iopscience.iop.org/article/10.1088/1755-1315/302/1/012076/pdf https://iopscience.iop.org/article/10.1088/1755-1315/302/1/012076 |
long_lat |
ENVELOPE(72.517,72.517,65.533,65.533) |
geographic |
Arctic Nadym |
geographic_facet |
Arctic Nadym |
genre |
Arctic nenets Nenets Autonomous Okrug Yamalo Nenets Yamalo-Nenets Autonomous Okrug |
genre_facet |
Arctic nenets Nenets Autonomous Okrug Yamalo Nenets Yamalo-Nenets Autonomous Okrug |
op_source |
IOP Conference Series: Earth and Environmental Science volume 302, issue 1, page 012076 ISSN 1755-1307 1755-1315 |
op_rights |
http://creativecommons.org/licenses/by/3.0/ https://iopscience.iop.org/info/page/text-and-data-mining |
op_doi |
https://doi.org/10.1088/1755-1315/302/1/012076 |
container_title |
IOP Conference Series: Earth and Environmental Science |
container_volume |
302 |
container_start_page |
012076 |
_version_ |
1800745626617511936 |