Improving access and efficiency of ischemic stroke treatment across four Canadian provinces using a stepped wedge trial: Methodology

• Published in: Frontiers in Stroke
• Main Authors: Kamal, Noreen, Aljendi, Shadi, Carter, Alix, Cora, Elena A., Chandler, Tania, Clift, Fraser, Fok, Patrick T., Goldstein, Judah, Gubitz, Gordon, Hill, Michael D., Menon, Bijoy K., Metcalfe, Brian, Mrklas, Kelly J., Phillips, Stephen, Theriault, Scott, Van Der Linde, Etienne, Volders, David, Williams, Heather
• Other Authors: Canadian Institutes of Health Research
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Frontiers Media SA 2022
• Subjects: Canada; Newfoundland; Prince Edward Island
• Online Access: http://dx.doi.org/10.3389/fstro.2022.1014480; https://www.frontiersin.org/articles/10.3389/fstro.2022.1014480/full

Introduction Ischemic stroke is treatable with thrombolysis and/or endovascular treatment. Both treatments are highly time dependent, as faster treatment results in better outcomes. Utilization of both of these treatments is less than optimal, and treatment times continue to exceed the recommended benchmarks. An improvement intervention was launched across Atlantic Canada, which has four provinces: Nova Scotia (NS), New Brunswick (NB), Prince Edward Island (PEI), and Newfoundland and Labrador (NL). The intervention was conducted through the ACTEAST (Atlantic Canada Together Enhancing Acute Stroke Treatment) Project, which aimed to improve access and efficiency of treatment for acute ischemic stroke patients. Intervention and methods The improvement intervention was a 6-month virtual Improvement Collaborative that consisted of each stroke center assembling an interdisciplinary team, 2 full-day Learning Sessions, five to six 1-h webinars, and a site visit for each team. The Improvement Collaborative intervention was implemented using a stepped-wedge trial design, where the intervention was delivered in 3 phases. The Improvement Collaborative was initially conducted with NS, followed by NB and PEI, and the final phase was with NL. The number of participants enrolled across all 34 hospitals were 98, 86, and 72 for NS, NB-PEI, and NL, respectively. The attendance at the Learning Sessions ranged from 43 to 81 across all 3 clusters. The attendance at webinars had a mean of 29.0 (SD 6.8), 26.0 (SD 6.3), and 19.0 (SD 8.5) for the NS, NB-PEI, and NL clusters respectively. (Anticipated) Results We anticipate that an additional 3–5% of ischemic stroke patients will receive thrombolysis, EVT, or both. Additionally, we anticipate a reduction of 10–15 min in door-to-needle times across the region. This will translate to an increase in the proportion of ischemic stroke patients that will be discharged home from acute care. Discussion High level of engagement is possible in an Improvement Collaborative Intervention when ...