Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis
Objective Dementia disproportionately affects First Nations populations. Biomarkers collected in primary care may assist with determining dementia risk. Our previous underpowered study showed some suggestive associations between baseline biomarkers with follow-up dementia or cognitive impairment. Th...
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Online Access: | http://dx.doi.org/10.3389/frdem.2023.1218709 https://www.frontiersin.org/articles/10.3389/frdem.2023.1218709/full |
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crfrontiers:10.3389/frdem.2023.1218709 2024-09-09T19:40:26+00:00 Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis Thompson, Fintan Russell, Sarah Quigley, Rachel McDonald, Malcolm Sagigi, Betty Taylor, Sean Campbell, Sandy Schmidt, Barbara Esterman, Adrian Harriss, Linton R. Miller, Gavin Mills, Phillip Strivens, Edward McDermott, Robyn National Health and Medical Research Council 2023 http://dx.doi.org/10.3389/frdem.2023.1218709 https://www.frontiersin.org/articles/10.3389/frdem.2023.1218709/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Dementia volume 2 ISSN 2813-3919 journal-article 2023 crfrontiers https://doi.org/10.3389/frdem.2023.1218709 2024-08-27T04:04:33Z Objective Dementia disproportionately affects First Nations populations. Biomarkers collected in primary care may assist with determining dementia risk. Our previous underpowered study showed some suggestive associations between baseline biomarkers with follow-up dementia or cognitive impairment. The current study extended this work with a larger linked dataset. Study design and setting Probabilistic data linkage was used to combine four baseline datasets with one follow-up assessment of dementia status 0–20 years later in a First Nations population in Australia. Mixed Effects Generalized Linear Regression models were used to test associations between baseline measures and follow-up status, accounting for repeated measures within individuals. Results Linked data were available for 88 individuals, with 101–279 baseline observations, depending on the type of measure. Higher urinary albumin to creatine ratio was associated with greater risk of cognitive impairment/dementia, whereas body weight and key lipid markers were negatively associated. There was no clear trend when these associations were examined by timing of measurement (i.e., ≤10 years or >10 years before a dementia assessment). Conclusions The results of this study support findings from our previous work and indicate that microalbuminuria can be an early indicator of dementia risk in this population. The weight and lipid profile findings reflect the mixed results in the published literature and require further investigation and interpretation. Article in Journal/Newspaper First Nations Frontiers (Publisher) Frontiers in Dementia 2 |
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Objective Dementia disproportionately affects First Nations populations. Biomarkers collected in primary care may assist with determining dementia risk. Our previous underpowered study showed some suggestive associations between baseline biomarkers with follow-up dementia or cognitive impairment. The current study extended this work with a larger linked dataset. Study design and setting Probabilistic data linkage was used to combine four baseline datasets with one follow-up assessment of dementia status 0–20 years later in a First Nations population in Australia. Mixed Effects Generalized Linear Regression models were used to test associations between baseline measures and follow-up status, accounting for repeated measures within individuals. Results Linked data were available for 88 individuals, with 101–279 baseline observations, depending on the type of measure. Higher urinary albumin to creatine ratio was associated with greater risk of cognitive impairment/dementia, whereas body weight and key lipid markers were negatively associated. There was no clear trend when these associations were examined by timing of measurement (i.e., ≤10 years or >10 years before a dementia assessment). Conclusions The results of this study support findings from our previous work and indicate that microalbuminuria can be an early indicator of dementia risk in this population. The weight and lipid profile findings reflect the mixed results in the published literature and require further investigation and interpretation. |
author2 |
National Health and Medical Research Council |
format |
Article in Journal/Newspaper |
author |
Thompson, Fintan Russell, Sarah Quigley, Rachel McDonald, Malcolm Sagigi, Betty Taylor, Sean Campbell, Sandy Schmidt, Barbara Esterman, Adrian Harriss, Linton R. Miller, Gavin Mills, Phillip Strivens, Edward McDermott, Robyn |
spellingShingle |
Thompson, Fintan Russell, Sarah Quigley, Rachel McDonald, Malcolm Sagigi, Betty Taylor, Sean Campbell, Sandy Schmidt, Barbara Esterman, Adrian Harriss, Linton R. Miller, Gavin Mills, Phillip Strivens, Edward McDermott, Robyn Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis |
author_facet |
Thompson, Fintan Russell, Sarah Quigley, Rachel McDonald, Malcolm Sagigi, Betty Taylor, Sean Campbell, Sandy Schmidt, Barbara Esterman, Adrian Harriss, Linton R. Miller, Gavin Mills, Phillip Strivens, Edward McDermott, Robyn |
author_sort |
Thompson, Fintan |
title |
Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis |
title_short |
Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis |
title_full |
Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis |
title_fullStr |
Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis |
title_full_unstemmed |
Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis |
title_sort |
primary care biomarkers and dementia in people of the torres strait, australia: extended data analysis |
publisher |
Frontiers Media SA |
publishDate |
2023 |
url |
http://dx.doi.org/10.3389/frdem.2023.1218709 https://www.frontiersin.org/articles/10.3389/frdem.2023.1218709/full |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Frontiers in Dementia volume 2 ISSN 2813-3919 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/frdem.2023.1218709 |
container_title |
Frontiers in Dementia |
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2 |
_version_ |
1809909751176232960 |