Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals
Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian cora...
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Online Access: | http://dx.doi.org/10.3389/fphys.2021.759370 https://www.frontiersin.org/articles/10.3389/fphys.2021.759370/full |
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crfrontiers:10.3389/fphys.2021.759370 2024-09-09T20:01:33+00:00 Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong 2022 http://dx.doi.org/10.3389/fphys.2021.759370 https://www.frontiersin.org/articles/10.3389/fphys.2021.759370/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Physiology volume 12 ISSN 1664-042X journal-article 2022 crfrontiers https://doi.org/10.3389/fphys.2021.759370 2024-08-13T04:04:35Z Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian coral growth. The fibroblast growth factor (FGF) signaling pathway is essential in coral budding morphogenesis. Here, we sequenced the full-length transcriptomes of four common and frequently dominant reef-building corals and screened out the budding-related FGF and FGFR genes. Thereafter, three-dimensional (3D) models of FGF and FGFR proteins as well as FGF-FGFR binding models were reconstructed. Based on our findings, the FGF8-FGFR3 binding models in Pocillopora damicornis , Montipora capricornis , and Acropora muricata are typical receptor tyrosine kinase-signaling pathways that are similar to the Kringelchen (FGFR) in hydra. However, in P . verrucosa , FGF8 is not the FGFR3 ligand, which is found in other hydrozoan animals, and its FGFR3 must be activated by other tyrosine kinase-type ligands. Overall, this study provides background on the potentially budding propagation signaling pathway activated by the applications of biological agents in reef-building coral culture that could aid in the future restoration of coral reefs. Article in Journal/Newspaper Ocean acidification Frontiers (Publisher) Frontiers in Physiology 12 |
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Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian coral growth. The fibroblast growth factor (FGF) signaling pathway is essential in coral budding morphogenesis. Here, we sequenced the full-length transcriptomes of four common and frequently dominant reef-building corals and screened out the budding-related FGF and FGFR genes. Thereafter, three-dimensional (3D) models of FGF and FGFR proteins as well as FGF-FGFR binding models were reconstructed. Based on our findings, the FGF8-FGFR3 binding models in Pocillopora damicornis , Montipora capricornis , and Acropora muricata are typical receptor tyrosine kinase-signaling pathways that are similar to the Kringelchen (FGFR) in hydra. However, in P . verrucosa , FGF8 is not the FGFR3 ligand, which is found in other hydrozoan animals, and its FGFR3 must be activated by other tyrosine kinase-type ligands. Overall, this study provides background on the potentially budding propagation signaling pathway activated by the applications of biological agents in reef-building coral culture that could aid in the future restoration of coral reefs. |
format |
Article in Journal/Newspaper |
author |
Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong |
spellingShingle |
Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
author_facet |
Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong |
author_sort |
Guo, Zhuojun |
title |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_short |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_full |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_fullStr |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_full_unstemmed |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_sort |
binding pattern reconstructions of fgf-fgfr budding-inducing signaling in reef-building corals |
publisher |
Frontiers Media SA |
publishDate |
2022 |
url |
http://dx.doi.org/10.3389/fphys.2021.759370 https://www.frontiersin.org/articles/10.3389/fphys.2021.759370/full |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Frontiers in Physiology volume 12 ISSN 1664-042X |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fphys.2021.759370 |
container_title |
Frontiers in Physiology |
container_volume |
12 |
_version_ |
1809933416939913216 |