Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo . KO characterization showed that 74.96% of the u...
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Online Access: | http://dx.doi.org/10.3389/fnut.2022.1003627 https://www.frontiersin.org/articles/10.3389/fnut.2022.1003627/full |
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crfrontiers:10.3389/fnut.2022.1003627 2024-09-09T19:12:18+00:00 Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats Huang, Luqiang Wu, Wenxin Huang, Linshan Zhong, Jiaze Chen, Lei Wang, Meiying Chen, Huibin Department of Education, Fujian Province National Natural Science Foundation of China 2022 http://dx.doi.org/10.3389/fnut.2022.1003627 https://www.frontiersin.org/articles/10.3389/fnut.2022.1003627/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Nutrition volume 9 ISSN 2296-861X journal-article 2022 crfrontiers https://doi.org/10.3389/fnut.2022.1003627 2024-08-27T04:04:08Z Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo . KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Euphausia superba Frontiers (Publisher) Antarctic Frontiers in Nutrition 9 |
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Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo . KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury. |
author2 |
Department of Education, Fujian Province National Natural Science Foundation of China |
format |
Article in Journal/Newspaper |
author |
Huang, Luqiang Wu, Wenxin Huang, Linshan Zhong, Jiaze Chen, Lei Wang, Meiying Chen, Huibin |
spellingShingle |
Huang, Luqiang Wu, Wenxin Huang, Linshan Zhong, Jiaze Chen, Lei Wang, Meiying Chen, Huibin Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
author_facet |
Huang, Luqiang Wu, Wenxin Huang, Linshan Zhong, Jiaze Chen, Lei Wang, Meiying Chen, Huibin |
author_sort |
Huang, Luqiang |
title |
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
title_short |
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
title_full |
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
title_fullStr |
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
title_full_unstemmed |
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
title_sort |
antarctic krill (euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
publisher |
Frontiers Media SA |
publishDate |
2022 |
url |
http://dx.doi.org/10.3389/fnut.2022.1003627 https://www.frontiersin.org/articles/10.3389/fnut.2022.1003627/full |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill Euphausia superba |
genre_facet |
Antarc* Antarctic Antarctic Krill Euphausia superba |
op_source |
Frontiers in Nutrition volume 9 ISSN 2296-861X |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fnut.2022.1003627 |
container_title |
Frontiers in Nutrition |
container_volume |
9 |
_version_ |
1809752973277921280 |