Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging
The complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea–land combination, the effects of sea-der...
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crfrontiers:10.3389/fnagi.2022.964077 2024-05-12T07:54:39+00:00 Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging Wang, Cheng-Cheng Kong, Jing-Ya Li, Xiao-Yue Yang, Jin-Yue Xue, Chang-Hu Yanagita, Teruyoshi Wang, Yu-Ming 2022 http://dx.doi.org/10.3389/fnagi.2022.964077 https://www.frontiersin.org/articles/10.3389/fnagi.2022.964077/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Aging Neuroscience volume 14 ISSN 1663-4365 Cognitive Neuroscience Aging journal-article 2022 crfrontiers https://doi.org/10.3389/fnagi.2022.964077 2024-04-18T07:57:08Z The complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea–land combination, the effects of sea-derived Antarctic krill oil (AKO) combined with land-derived nobiletin (Nob) and L-theanine (The) on memory loss and cognitive deficiency were studied in senescence-accelerated prone 8 mice (SAMP8). The results demonstrated that AKO combined with The significantly increased the number of platform crossings in the Morris water maze test by 1.6-fold, and AKO combined with Nob significantly increased the preference index in a novel object recognition test. AKO exhibited synergistic effects with Nob and The in ameliorating recognition memory and spatial memory deficiency in SAMP8 mice, respectively. Further research of the mechanism indicated that AKO exhibited synergistic effects with Nob in suppressing β-amyloid (Aβ) aggregation, neurofibrillary tangles, and apoptosis and neuroinflammation, while the synergistic effects of AKO and The involved in synaptic plasticity and anti-neuroinflammation, which revealed that the combination was complex, not a mechanical addition. These findings revealed that the sea–land combination may be an effective strategy to treat and alleviate AD. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Frontiers (Publisher) Antarctic Frontiers in Aging Neuroscience 14 |
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Cognitive Neuroscience Aging |
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Cognitive Neuroscience Aging Wang, Cheng-Cheng Kong, Jing-Ya Li, Xiao-Yue Yang, Jin-Yue Xue, Chang-Hu Yanagita, Teruyoshi Wang, Yu-Ming Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
topic_facet |
Cognitive Neuroscience Aging |
description |
The complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea–land combination, the effects of sea-derived Antarctic krill oil (AKO) combined with land-derived nobiletin (Nob) and L-theanine (The) on memory loss and cognitive deficiency were studied in senescence-accelerated prone 8 mice (SAMP8). The results demonstrated that AKO combined with The significantly increased the number of platform crossings in the Morris water maze test by 1.6-fold, and AKO combined with Nob significantly increased the preference index in a novel object recognition test. AKO exhibited synergistic effects with Nob and The in ameliorating recognition memory and spatial memory deficiency in SAMP8 mice, respectively. Further research of the mechanism indicated that AKO exhibited synergistic effects with Nob in suppressing β-amyloid (Aβ) aggregation, neurofibrillary tangles, and apoptosis and neuroinflammation, while the synergistic effects of AKO and The involved in synaptic plasticity and anti-neuroinflammation, which revealed that the combination was complex, not a mechanical addition. These findings revealed that the sea–land combination may be an effective strategy to treat and alleviate AD. |
format |
Article in Journal/Newspaper |
author |
Wang, Cheng-Cheng Kong, Jing-Ya Li, Xiao-Yue Yang, Jin-Yue Xue, Chang-Hu Yanagita, Teruyoshi Wang, Yu-Ming |
author_facet |
Wang, Cheng-Cheng Kong, Jing-Ya Li, Xiao-Yue Yang, Jin-Yue Xue, Chang-Hu Yanagita, Teruyoshi Wang, Yu-Ming |
author_sort |
Wang, Cheng-Cheng |
title |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_short |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_full |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_fullStr |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_full_unstemmed |
Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea–land combination to retard brain aging |
title_sort |
antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in samp8 mice: applying the perspective of the sea–land combination to retard brain aging |
publisher |
Frontiers Media SA |
publishDate |
2022 |
url |
http://dx.doi.org/10.3389/fnagi.2022.964077 https://www.frontiersin.org/articles/10.3389/fnagi.2022.964077/full |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Frontiers in Aging Neuroscience volume 14 ISSN 1663-4365 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fnagi.2022.964077 |
container_title |
Frontiers in Aging Neuroscience |
container_volume |
14 |
_version_ |
1798851032466325504 |